| CAS: | 8001-27-2 | ||||
| 英文名称: |
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| 用途: | 重组水蛭素可能具有抗原性。独立研究发现，在使用重组水蛭素治疗数天的患者中，有50-70％的患者产生至少一种水蛭素抗体亚型。这些抗体可降低水蛭素的抗凝血作用，但可以通过减少肾脏过滤来延长其血浆半衰期。水蛭素是一种抗凝血剂，它是可溶性和凝块结合凝血酶的最有效的天然抑制剂。它以高亲和力结合凝血酶，覆盖其表面积的20％以上并阻断活性位点和外部位点I（纤维蛋白原和PAR识别位点）。水蛭素能够阻止血栓生长和血小板活化。它不会在人体血液中代谢，并且可以通过肾脏过滤清除。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||
| H922245 | MACKLIN | 重组水蛭素 来源于酵母 | 1690元/50U; 3289元/100U; | 展开 | |||||||||||||||||||||||||||||||||||
储存：−20°C 状态：白色粉末 | |||||||||||||||||||||||||||||||||||||||
| 94581 | Sigma-Aldrich | Hirudin recombinant from yeast | lyophilized powder, white, >1500 U/vial | 14946.3元/1 EA; | 展开 | ||||||||||||||||||||||||||||||||||
产品说明 应用 来自酵母的重组水蛭素已被用于甘露聚糖结合凝集素丝氨酸蛋白酶2(MASP2)活化测定。 它还用于在磷酸盐缓冲盐水(PBS)中预处理纳米片，以用于血小板粘附测定。 生化/生理作用 重组水蛭素可能具有抗原性。独立研究发现，在使用重组水蛭素治疗数天的患者中，有50-70％的患者产生至少一种水蛭素抗体亚型。这些抗体可降低水蛭素的抗凝血作用，但可以通过减少肾脏过滤来延长其血浆半衰期。 单位定义 1个单位对应于1个ATU(抗凝血酶单位；1个ATU是指中和1个NIH单位凝血酶所需的抑制剂量)。 基本信息
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| H0393 | Sigma-Aldrich | Hirudin | recombinant, expressed in unspecified host, ≥7,000 ATU/mg protein (ATU = antithrombin units) | 4082.29元/100 UNITS; 14111.7元/500 UNITS; | 展开 | ||||||||||||||||||||||||||||||||||
产品说明 应用 Antithrombotic efficacy by parenteral route is substantially prolonged by incorporation into cationic liposomes, which act as a sort of sustained-release device. 物理属性 The anticoagulant hirudin is a ~7 kDa acidic protein containing 65 amino acid residues. It occurs naturally in leeches (Hirudo medicinalis). It is the most potent natural inhibitor of both soluble and clot-bound thrombin. Hirudin binds thrombin with high affinity and covers more than 20% of the surface area of thrombin, occluding both the active site and exosite I (fibrinogen and PAR recognition site). This coverage blocks thrombus growth and platelet activation. Hirudin is not metabolized in the bloodstream of humans and is eliminated unchanged via kidney filtration. Native hirudin contains a sulfated tyrosyl residue (Tyr63), three disulfide bridges, and a high proportion of dicarboxylic acids. Hirudin is not glycosylated, and lacks tryptophan, arginine, and methionine residues. At least 20 isoforms have been identified and sequenced. 单位定义 One unit (ATU) will neutralize one NIH unit of thrombin at 37 ℃, based on direct comparison to an NIH thrombin reference standard. 重悬 Hirudin is soluble in water. The literature cites the use of "Dilution Fluid II" (35.7 mM acetic acid, 35.7 mM sodium diethyl barbiturate, 0.85% NaCl, 1% bovine serum albumin, and 0.5% PEG, pH 7.4) to dissolve hirudin (500 ATU/mL) and thrombin. Hirudin is reported to be soluble in pyridine, but practically insoluble in alcohol, ether, acetone, or benzene. 分析说明 Protein determined by Lowry. 基本信息
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