CAS 79055-68-8; d(-)-2-amino-5-phosphonovaleric acid hydrate

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CAS:

79055-68-8

分子式:

C5H12NO5P.xH2O

分子量:

197.13

英文名称:

d(-)-2-amino-5-phosphonovaleric acid hydrate

用途:

D-AP5 is a selective antagonist of the NMDA receptor. D(-)-2-Amino-5-phosphonovaleric acid is described to antagonize amino acid-induced synaptic excitations, blocking L-aspartate and dorsal root-evoked spinal neuron excitation, without affecting cholinergic excitation induced by exogenous acetylcholine administration. Evoked electrical activity of neurons is suppressed by D(-)-2-Amino-5-phosphonovaleric acid antagonism of motoneuronal depolarizations at the NMDAR. The (+)-stereoisomer of D(-)-2-Amino-5-phosphonovaleric acid demonstrates considerably diminished NMDAR activity as compared to this (-)-isomer.

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

R864577

MACKLIN

(R)-(-)-2-氨基-5-膦酰戊酸

99%

258元/1mg; 735元/5mg; 2298元/25mg;

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储存：室温
状态：白色到灰白色固体

A8054

Sigma-Aldrich

D(-)-2-Amino-5-phosphonopentanoic acid

NMDA receptor antagonist

874.65元/1 MG; 2531.83元/5 MG; 4373.19元/10 MG;

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产品说明

应用

D (-)-2-氨基-5-膦戊酸已被用于预处理 BNST(终纹床核)，以阻止 ORX-A(食欲素-A)引入 BNST 的焦虑。

包装

1, 5, 10 mg in serum bottle

生化/生理作用

NMDA 拮抗剂具有肌肉松弛属性，对缺血引起的脑损伤具有神经元保护作用。2-氨基-5-膦甲酸已被证明可以阻断离子导入引起的 NMDA 的去极化。
抗惊厥药；强效和选择性N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂；2-氨基-5-膦酰戊酸的活性对映体。

基本信息

经验(实验)分子式	C₅H₁₂NO₅P
分子量	197.13
MDL编号	MFCD00078839
PubChem化学物质编号	24891311
NACRES	NA.26

产品性质

质量水平	100
测定	≥98% (TLC)
形式	powder
光学纯度	optical purity: ≥90% (HPLC, Marfey′s reagent)
technique(s)	ligand binding assay: suitable
颜色	white
mp	245-246 ℃
SMILES string	N[C@H](CCCP(O)(O)=O)C(O)=O
InChI	1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
InChI key	VOROEQBFPPIACJ-SCSAIBSYSA-N
Gene Information	mouse ... Grin2a(14811) rat ... Grik1(29559), Grin2a(24409), Grin2b(24410), Grin2c(24411), Grin2d(24412)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

165304

Sigma-Aldrich

D-(–)-2-Amino-5-phosphonopentanoic Acid-CAS 79055-68-8-Calbiochem

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used as a competitive NMDA receptor antagonist.

2005.33元/5 MG;

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产品说明

一般描述

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist.
Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used as a competitive NMDA receptor antagonist. Also inhibits the capsaicin-induced release of substance P from spinal cord.

包装

5 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
NMDA receptor antagonist

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Malcangio, M., et al. 1998. Br. J. Pharmacol. 125, 1625.
Schulte, M.K., et al. 1994. Brain Res. 649, 203.
Davis, S., et al. 1992. J. Neurosci. 12, 21.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₅H₁₂NO₅P
分子量	197.13
MDL编号	MFCD00078839

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	white
溶解性	dilute aqueous base: 1 mg/mL water: 1 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/p-2/t4-/m1/s1
InChI key	VOROEQBFPPIACJ-SCSAIBSYSA-L

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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