| CAS: | 775294-82-1 | ||
| 分子式: | C24H27ClN2O4 | ||
| 分子量: | 442.94 | ||
| 英文名称: |
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| 用途: | SBE13 是一种有效的，选择性的 Plk1 抑制剂，IC50 值为 200 pM，对 Plk2 (IC50>66 μM) 或 Plk3 (IC50=875 nM) 的作用较弱。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||
| S877422 | MACKLIN | SBE13 | 98% | 799元/10mg; 3036元/50mg; | 咨询 | ||||||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||||||
| 528281 | Sigma-Aldrich | Polo-like Kinase Inhibitor IV, SBE13-CAS 775294-82-1-Calbiochem | The Polo-like Kinase Inhibitor IV, SBE13, also referenced under CAS 775294-82-1, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylati | 2165.23元/10 MG; | 咨询 | ||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM. 包装 Packaged under inert gas 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Keppner, S., et al. 2009. ChemMedChem.4, 1806. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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