基本信息

技术规格

物性(参考值)

基本信息

安全信息

Technical Notes:

1. (R)-BINAP or (R)-ToI-BINAP can be combined with dichloro(1 , 5-cyclooctadiene )ruthenium to form precursors to NOYORI CATALYST SYSTEMS. These systems exhibit very high catalytic activity and enantioselectivity in the hydrogenation of a wide range of substrates. NOYORI

CATALYST SYSTEMS have been shown to effect highly enantioselective hydrogenation of functionalized ketones where the substituents are dialkylamino, hydroxy, siloxy, carbonyl,ester, amide or thioester.

2. Useful ligand in asymmetric Heck processes.

3.Ligand employed in palladium-catalyzed asymmetric arylation of ketones.

4.Ligand employed in rhodium-catalyzed 1 ,4-additions to enones.

5.Ligand employed in palladium-catalyzed hydroamination of styrene derivatives.

6.Ligand employed in silver-catalyzed asymmetric Sakuri-Hosomi allylation and Mukaiyama aldol reaction.

7.Ligand employed in rhodium-catalyzed kinetic resolution of enynes.

8.Ligand employed in asymmetric rhodium-catalyzed hydroboration of cyclopropenes.

9. Ligand employed in silver-catalyzed a-hydroxylation of stannyl enol ethers.

10. Ligand employed in palladium-catalyzed synthesis of chiral allenes .

11.Ligand for P alladium-catalyzed enantiose lective hetero Michael addition to form b-amino acid derivatives .

12.Ligand employed in rhodium-catalyzed asymmetric rearrangement of alkynyl alkenyl carbinols

13.Ligand employed in rhodium-catalyzed 1 ,2-addition of aluminium organyl compounds to cyclic enones.

14.Ligaand employed in iridium-catalyzed transfer hydrogenative allylation of benzylic alcohol

15.Ligand employed in rhodium catalyzed asymmetric C-Si bond formation by conjugate silyl transfer using a Si-Blinkage.

16. Ligand employed in the iridium-catalyzed asymmetric cyclopropane -mediated carbonyl allylation of primary

alcohols.

17. L igand employed in the nickel-catalyzed asymmetric a-arylation of tetralones.

19.Ligand employed in the copper-catalyzed asymmetric propargylation of ketones.

20.Ligand employed in the cobalt- catalyzed asymmetric reductive coupling of alkynes with alkenes.

21Ligand employed in the rhodium-catalyzed asymmetric 1 ,4-addition of arylalanes on trisubstituted enones. Ruthenium-catalyzed asymmetric hydrocyanation of imines.

22.Palladium-catalyzed asymmetric intermolecular cyclization.

应用
(R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthy is used as a chiral ligand for metal mediated asymmetric catalysis.

备注
Air sensitive. Incompatible with oxidizing agents.

基本信息

MDL
MFCD00010805

分子式
C₄₄H₃₂P₂

分子量
622.69

熔点
239-241°

灵敏度
Air Sensitive. Store under Nitrogen. Ambient temperatures.

形态
Crystalline powder

溶解性
Insoluble in water.

Beilstein
4914063

Merck
14,1223

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

TSCA
否

基本信息

Ref#
26553

MDL
10805

分子式
C44 H32 P2

分子量
622.67

形态
Crystalline

产品说明

一般描述

(R)-(+)-2,2′-双(二苯基膦基)-1,1′-双萘是用于不对称反应的轴向不对称双(三芳基)膦配体。

应用

过渡金属催化的不对称反应(包括氢化和二甲硅烷基化)的有用配体。2,2′-双(二苯基膦基)-1,1′-联萘基及其铑和钌衍生物是还原芳基酮、β-酮酸酯和 α-氨基酮的高选择性均相催化剂。它们也已用于烯烃的不对称氢化和加氢甲酰化，不对称 Heck 反应和烯丙基的不对称异构化。
与 Ag(I)的络合物可用于催化烯基三氯乙酸酯和醛之间的不对称羟醛反应。也可与 Ag(I)一起催化偶氮化合物的对映选择性杂 Diels-Alder 反应。

包装

250 mg in glass insert
1, 5 g in glass bottle

基本信息

产品性质

安全信息

产品说明

应用

用于不对称反应的 Takasago 配体和复合物
(R)-BINAP 与烯丙基氯化钯 (II) 二聚体反应生成 BINAP-钯催化剂，可催化 1，3-二酮的不对称烯丙基化反应生成手性 2，2-二烷基-1，3-二酮。也可用于制备手性稳定的铑纳米粒子，可作为催化剂用于苯乙烯和醋酸乙烯酯的不对称氢甲酰化反应。

包装

100, 500 mg in amber glass bottle

法律信息

与 Takasago 联合销售，仅供研究使用。

基本信息

产品性质

安全信息

基本信息

安全信息

基本信息

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H332: Harmful if inhaled. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .