CAS 75567-37-2; ingenol-3-angelate

CAS:

75567-37-2

分子式:

C₂₅H₃₄O₆

分子量:

430.53

英文名称:

ingenol-3-angelate

ingenol mebutate

(1ar,2S,5R,5as,6S,8as,9R,10ar)-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1h-2,8a-methanocyclopenta[a]cyclpropa[e][10]annulen-6-yl (2z)-2-methylbut-2-enoate

3-ingenyl angelate

pep005

3-angeloylingenol

i3a

用途:

Ingenol Mebutate (PEP 005)存在于大戟植物的树液中，是细胞死亡诱导剂。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

I860592

MACKLIN

巨大戟醇甲基丁烯酸酯

>98%

588元/1mg; 1497元/5mg; 2245元/10mg;

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储存：-20°C
状态：灰白色粉末

1563361

J&K

Ingenol mebutate

98%, 来源于千金子

2000元/20MG;

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基本信息

分子式	C₂₅H₃₄O₆
分子量	430.53

SML1318

Sigma-Aldrich

Ingenol-3-angelate

≥95% (HPLC)

1677元/1 MG;

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产品说明

包装

1 mg in glass bottle

生化/生理作用

Ingenol-3-angelate, is a phorbol ester-like compound or a diacylglycerol analog that is used in the treatment of several disorders like skin cancer. It is also known as PEP005. Ingenol-3-angelate stimulates the initiation of the enzyme by providing PKCs (protein kinase C) to cellular membranes.
Ingenol 3-Angelate is a diterpenoid ester isolated from Euphorbia peplus that induces rapid cell death with keratinocytes and some cancer cell lines. Ingenol 3-Angelate is a protein kinase C activator that displays potent antileukemic activity. Ingenol 3-Angelate (ingenol mebutate) is used for treatment of actinic keratosis.

基本信息

经验(实验)分子式	C₂₅H₃₄O₆
分子量	430.53
PubChem化学物质编号	329825782
NACRES	NA.77

产品性质

生物来源	semisynthetic
质量水平	100
测定	≥95% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 15 mg/mL, clear
储存温度	−20℃
SMILES string	O=C1[C@@]2(C=C(C)[C@@H]3OC(/C(C)=C\C)=O)[C@]3(O)[C@H](O)C(CO)=C[C@@]1([H])[C@@](C4(C)C)([H])[C@@]4([H])C[C@H]2C
InChI	1S/C25H34O6/c1-7-12(2)22(29)31-21-13(3)10-24-14(4)8-17-18(23(17,5)6)16(20(24)28)9-15(11-26)19(27)25(21,24)30/h7,9-10,14,16-19,21,26-27,30H,8,11H2,1-6H3/b12-7-/t14-,16+,17-,18+,19-,21+,24+,25+/m1/s1
InChI key	VDJHFHXMUKFKET-WDUFCVPESA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable