CAS 75530-68-6; 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-5-pyridinedicarboxylic acid

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货号

品牌

产品名称

规格

包装、参考价格

N866800

MACKLIN

尼伐地平

≥95%

258元/200mg;

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储存：室温
状态：淡黄色到黄色绿色晶体或粉末

N797247

MACKLIN

尼伐地平

10mM in DMSO

468元/1ml;

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储存：-20°C

N0899

TCI

Nilvadipine

>95.0%(N)

870元/1G; 3025元/5G;

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基本信息

纯度/分析方法	>95.0%(N)
分子式/分子量	C₁₉H₁₉N₃O₆ = 385.38
外观与形状(20℃)	固体
Reaxys-RN	3572609
PubChem物质ID	135727167
Merck Index (14)	6545
MDL编号	MFCD00867065

技术规格

Appearance	Light yellow to Amber to Dark green powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 95.0 %
Melting point	149.0 to 153.0 ℃

物性(参考值)

熔点	151 ℃
水溶性	不溶
溶解性(可溶于)	甲醇
溶解性(微溶于)	乙醇

安全信息

图形或危害标志
信号词	警告
危险性说明	H302 + H312 + H332 : 吞咽、皮肤接触或吸入有害。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P261 : 避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾。 P270 : 使用本产品时不要进食、饮水或吸烟。 P271 : 只能在室外或通风良好之处使用。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。 P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。 P302 + P352 + P312 : 如皮肤沾染：用水充分清洗。如感觉不适，呼叫急救中心/医生。 P304 + P340 + P312 : 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。如感觉不适，呼叫急救中心/医生。

相关法规

RTECS#

US7968300

SML0945

Sigma-Aldrich

Nilvadipine

≥98% (HPLC)

551.68元/10 MG; 1538.21元/50 MG;

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产品说明

一般描述

Nilvadipine is a dihydropyridine drug.

包装

10, 50 mg in glass bottle

生化/生理作用

Nilvadipine is a potent calcium channel blocker that is used for treatment of hypertension. Nilvadipine, as other dihydropyridine calcium antagonists, decreases intracellular calcium concentration causing dilation of the coronary and systemic arteries. Nilvadipine acutely reduced brain Aβ levels in a transgenic mouse model of Alzheimer′s disease (AD).
Nilvadipine, apart from its antihypertensive effect, is known to decrease the accumulation of β-amyloid protein in the brain. Therefore, it is effective in the treatment of Alzheimer′s disease. Nilvadipine also promotes cognitive function in hypertensive patients.

基本信息

经验(实验)分子式	C₁₉H₁₉N₃O₆
分子量	385.37
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 15 mg/mL, clear
储存温度	room temp
InChI	1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16(15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3
InChI key	FAIIFDPAEUKBEP-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

463476

Fluorochem

Nilvadipine

95%

1694元/1g; 5632元/5g;

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基本信息

CAS Number	75530-68-6
MDL Number	MFCD00867065

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H312: Harmful in contact with skin. H315: Causes skin irritation. H319: Causes serious eye irritation. H332: Harmful if inhaled. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P322: Specific measures (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P363: Wash contaminated clothing before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.