| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| H906869 | MACKLIN | 7,8-二羟基-3-(4-羟基苯基)苯并吡喃-4-酮 | 98% | 96元/1g; 360元/5g; 1568元/25g; | 咨询 |
|
| 998261 | J&K | 7,8-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-one | 98% | 1583元/250MG; 4234元/1G; 12185元/5G; | 咨询 |
基本信息 | 分子式 | C15H10O5 | | 分子量 | 286.3250 | | MDL编码 | MFCD00800693 |
|
| 5.31050 | Sigma-Aldrich | PFKFB3 Inhibitor III, YN1-CAS 75187-63-2-Calbiochem | | 2093.35元/25 mg; | 咨询 |
产品说明 一般描述 A cell-permeable isoflavone compound that acts as a potent and competitive inhibitor of fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 670 nM; Ki = 240 nM). Directly docks into the Fru-6-P binding pocket of PFKFB3 and down-regulates Fru-2,6-BP levels (40% decrease in 48 h in HeLa cells) resulting in reduced glycolysis and lactate production. Shown to diminish the proliferation of HCT-116 human adenocarcinoma cells (GI50 = 8.2 µM) and inhibit HeLa cells colony formation on soft agar (~79% reduction at 25 µM). Induces apoptotic (~25 µM) and necrotic (~50 µM) cell death depending on the level of ATP depletion. Also reported to increase autophagy in HCT-116 cells as evidenced by an increase in LC3-II levels and a decrease in p62 levels
A cell-permeable isoflavone compound that acts as a potent and competitive inhibitor of fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 670 nM; Ki = 240 nM). Directly docks into the Fru-6-P binding pocket of PFKFB3 and down-regulates Fru-2,6-BP levels (40% decrease in 48 h in HeLa cells) resulting in reduced glycolysis and lactate production. Shown to diminish the proliferation of HCT-116 human adenocarcinoma cells (GI50 = 8.2 µM) and inhibit HeLa cells colony formation on soft agar (~79% reduction at 25 µM). Induces apoptotic (~25 µM) and necrotic (~50 µM) cell death depending on the level of ATP depletion. Also reported to increase autophagy in HCT-116 cells as evidenced by an increase in LC3-II levels and a decrease in p62 levels.
Please note that the molecular weight for this compound is batch-specific due to variable water content. 生化/生理作用 Cell permeable: yes
Reversible: yes 包装 Packaged under inert gas 警告 Toxicity: Regulatory Review (Z) 其他说明 Klarer, A. C., et al. 2014. Cancer Metab.2, 2.
Seo, M., et al. 2011. PLoS ONE6, e24179. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | powder | | 效能 | 670 nM IC50 | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze
protect from light | | 颜色 | off-white | | 溶解性 | DMSO: 100 mg/mL | | 储存温度 | 2-8℃ | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19/h1-7,16-17,19H | | InChI key | BMZFZTMWBCFKSS-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| SML0947 | Sigma-Aldrich | YN1 | ≥98% (HPLC) | 1041.72元/10 MG; 3377.12元/50 MG; | 咨询 |
产品说明 包装 10, 50 mg in glass bottle 生化/生理作用 YN1 is a potent inhibitor of PFKFB3 (6-Phosphfructo-2-kinase/fructose-2,6-bisphosphatase: IC50 = 670 nM). PFKFB3 is over expressed in many cancers, and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YN1 inhibits glycolysis and proliferation in HeLa cells. 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 |
产品性质 | 测定 | ≥98% (HPLC) | | 形式 | powder | | 储存条件 | desiccated | | 颜色 | white to beige | | 溶解性 | DMSO: 10 mg/mL, clear | | 储存温度 | 2-8℃ | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19/h1-7,16-17,19H | | InChI key | BMZFZTMWBCFKSS-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| 024980 | Fluorochem | 7,8-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-one | 98% | 2354元/250mg; 7084元/1g; 21208元/5g; | 咨询 |
基本信息 | CAS Number | 75187-63-2 | | MDL Number | MFCD00885567 | | Melting Point | >280℃ |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H332: Harmful if inhaled.
| | 防范说明 | P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to local regulations.
|
|
m.cnreagent.com