| CAS: | 749872-43-3 | ||||
| 分子式: | C16H18N2O7S | ||||
| 分子量: | 382.39 | ||||
| 英文名称: |
| ||||
| 用途: | CID 5951923 is an inhibitor of Kruppel-like factor 5 (KLF5) expression that significantly reduced endogenous KLF5 protein levels and decreased viability of several colorectal cancer cell lines. CID 5951923 is selective for colon cancer cells over nontransformed cells. |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||
| C921033 | MACKLIN | 3-(3-硝基苯基)-2-丙烯酸2-[甲基(四氢-1,1-二氧基-3-噻吩基)氨基]-2-氧代乙基酯 | ≥98% (HPLC) | 1608元/5mg; | 咨询 | ||||||||||||||||||||||||||||||||||
储存：室温 状态：固体 | |||||||||||||||||||||||||||||||||||||||
| 422625 | Sigma-Aldrich | KLF5 Inhibitor, CID 5951923-CAS 749872-43-3-Calbiochem | The KLF5 Inhibitor, CID 5951923 controls the biological activity of KLF5. | 2096.01元/10 MG; | 咨询 | ||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182. 包装 10 mg in Glass bottle 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C. 其他说明 Bialkowska, A., et al. 2011. Mol. Cancer Ther.10, 2043. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
产品性质
安全信息
| |||||||||||||||||||||||||||||||||||||||
m.cnreagent.com