CAS 74611-28-2; methiothepin mesylate salt

CAS:

74611-28-2

分子式:

C₂₁H₂₈N₂O₃S₃

分子量:

452.65

英文名称:

methiothepin mesylate salt

1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt

metitepine mesylate salt

用途:

Methiothepin mesylate 是一种有效的，非选择性的 5-HT2 receptor 拮抗剂，pKd 值为 7.10 (5-HT1A)，7.28 (5HT1B)，7.56 (5HT1C)，6.99 (5HT1D)，7.0 (5-HT5A)，7.8 (5-HT5B)，8.74 (5-HT6) 和 8.99 (5-HT7)，pKi 值为 8.50 (5HT2A)，8.68 (5HT2B) 和 8.35 (5HT2C)。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

M877554

MACKLIN

Methiothepin mesylate

≥99%

568元/10mg; 1880元/50mg;

咨询

储存：2-8℃

M149

Sigma-Aldrich

Methiothepin mesylate salt

≥98% (HPLC), solid

1682.59元/100 MG; 2833.54元/250 MG;

咨询

产品说明

一般描述

Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.

应用

Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.

包装

100, 250 mg in glass bottle

生化/生理作用

Methiothepin mesylate salt is a 5-HT₁, 5-HT₆, 5-HT₇ serotonin receptor antagonist, which blocks serotonin autoreceptors.

基本信息

线性分子式	C₂₀H₂₄N₂S₂ · CH₃SO₃H
分子量	452.65
MDL编号	MFCD00153831
PubChem化学物质编号	24278104
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
储存条件	desiccated
颜色	white
溶解性	H₂O: 13 mg/mL
SMILES string	CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1
InChI	1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)
InChI key	CZMDZGZYKOGLJY-UHFFFAOYSA-N
Gene Information	human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR6(3362), HTR7(3363)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)