CAS 709002-46-0; sirreal2

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CAS:

709002-46-0

分子式:

C₂₂H₂₀N₄OS₂

分子量:

420.55

英文名称:

sirreal2

2-(4,6-dimethyl-pyrimidin-2-ylsulfanyl)-n-(5-naphthalen-1-ylmethyl-thiazol-2-yl)-acetamide

sirreal 2

用途:

SirReal2是一种有效的选择性Sirt2抑制剂，IC50为140 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S872946

MACKLIN

SirReal2

99%

298元/1mg; 688元/5mg; 1980元/25mg; 4760元/100mg;

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储存：-20℃
状态：粉末

S797411

MACKLIN

SirReal2

10mM in DMSO

620元/1ml;

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储存：-20°C

SML1514

Sigma-Aldrich

SirReal2

≥98% (HPLC)

1399.43元/5 MG; 5643.95元/25 MG;

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产品说明

应用

Sirtuin-rearranging ligand 2 (SirReal2) has been used as a positive control to evaluate in vivo sirtuin 2 (SIRT2) inhibition by RK-9123016 and NPD11033.

包装

5, 25 mg in glass bottle

生化/生理作用

SirReal2 is a potent and selective inhibitor of Sirt2, an NAD-dependent lysine deacetylase that has been implicated in the pathogenesis of cancer, inflammation, and neurodegeneration. SirReal2 has an IC₅₀ value of 140 nM and is >1000-fold selective for Sirt2 over Sirt1 and Sirt3. SirReal2 is believed to act through a ligand-induced structural rearrangement of the active site, binding at an adjacent pocket to lock Sirt2 in an open conformation. SirReal2 caused to tubulin hyperacetylation in HeLa cells and destabilization of the checkpoint protein BubR1, consistent with Sirt2 inhibition.

基本信息

经验(实验)分子式	C₂₂H₂₀N₄OS₂
分子量	420.55
PubChem化学物质编号	329825931
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	−20℃
SMILES string	CC1=NC(SCC(NC2=NC=C(S2)CC3=CC=CC4=C3C=CC=C4)=O)=NC(C)=C1
InChI	1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27)
InChI key	MENNDDDTIIZDDN-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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