[登录] [免费注册]
试剂仪器网
位置:首页 > 资料中心 > 化工字典 > 6928-85-4
关键词:       仅模糊查询
CAS: 6928-85-4
分子式: C5H13N3
分子量: 115.18
沸点: 172-175℃
中文名称: 
4-甲基-1-哌嗪胺
N-甲基-N'-氨基哌嗪
1-氨基-4-甲基哌嗪
1-氨基-4-甲基对二氮己烷
利福平侧链
英文名称: 
1-Piperazinamine,4-methyl-
4-methyl-1-Piperazinamine
N-Methyl-N'-aminopiperazine
1-amino-4-methylpiperazine
性质描述: 沸点172-175℃,相对密度0.957,折光率1.4850,闪点62℃。
生产方法: 以六水哌嗪为原料,经甲基化、水解、亚硝化,还原等步骤得到。(1)甲基化将六水哌嗪溶于甲酸中,吸入反应锅内,升温到90℃,搅拌下滴加甲醛约1h,加毕,于90-95℃保温反应1h,减压蒸去水及过量的原料,得甲基甲酰基哌嗪浓缩液。(2)水解将盐酸和水加到上述浓缩液中,搅拌升温至105℃,回流反应2h。减压蒸馏至无馏出液为止,弃去馏出的酸液,残留液冷至15℃,放置过夜,过滤,滤液即甲基哌嗪盐酸盐溶液。(3)亚硝化将水解步骤得到的滤液在30℃滴加亚硝酸钠溶液,加毕,保温反应30min,得甲基硝基哌嗪生成液。(4)还原在亚硝化生成液中加入冰醋酸,冷却,于30-40℃逐步加入锌粉,加毕,于30-40℃保温反应1.5h,冷至15℃左右,放置过夜,甩滤。将此还原滤液加至预先已配置液碱并冷至10℃以下的碱化锅中,充分冷却后送至萃取锅,分3次加入氯仿进行萃取,合并氯仿萃取液,进行常压蒸馏回收氯仿,至液温为85℃时转入精馏锅中,先常压蒸馏至液温为135℃,再进行减压蒸馏,收集120℃(5.33-8.0kPa)馏分即为1-氨基-4-甲基哌嗪。上述四个步骤的总收率约30%。原料消耗定额:六水哌嗪(95%)1148.1kg/t、甲酸(85%)2266.2kg/t、甲醛(37%)1130.8kg/t、锌粉(90%)1900.2kg/t、冰乙酸3759.4kg/t、浓盐酸4046.5kg/t、亚硝酸钠937.6kg/t。
用途: 医药中间体,用于生产抗菌素利福平。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
A824026MACKLIN1-氨基-4-甲基哌嗪98%30元/5ml;   63元/25ml;   234元/100ml;   1100元/500ml;   展开
储存:室温,干燥,密封
状态:无色澄清液体
物化性质:water: soluble
折射率:n20/D 1.485(lit.)
A1192TCI1-Amino-4-methylpiperazine>98.0%(GC)(T)455元/25ML;   5690元/500ML;   展开

基本信息

纯度/分析方法>98.0%(GC)(T)
分子式/分子量C5H13N3 = 115.18
外观与形状(20℃)液体
储存在惰性气体下存放于惰性气体之中
应避免的情况光,空气
Reaxys-RN103334
PubChem物质ID87562668
SDBS (AIST Spectral DB)11745
MDL编号MFCD00006154

技术规格

AppearanceColorless to Almost colorless clear liquid
Purity(GC)min. 98.0 %
Purity(Nonaqueous Titration)min. 98.0 %

物性(参考值)

沸点175 ℃
闪点103 ℃
比重0.96
折射率1.48

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
200248J&K1-Amino-4-methylpiperazine98%99元/5G;   397元/25G;   1236元/100G;   展开

基本信息

分子式C5H13N3
分子量115.18
沸点172-175
闪点63
密度0.957
折光率(n20D)1.4835 - 1.4855
MDL编码MFCD00006154
Beilstein103334
EINECS 编号230-053-7

安全信息

图形或危害标志
提示语Warning
危险说明H302
H312
H315
H319
H332
H335
防范说明P261
P280
P305+P351+P338
WGK3
L19108Alfa Aesar1-Amino-4-methylpiperazine98%947元/25g;   2926元/100g;   展开

基本信息

MDL
MFCD00006154

EINECS
230-053-7

分子式
C5H13N3

分子量
115.18

沸点
172-175°

闪点
70°(158°F)

密度
0.960

折射率
1.4840

Beilstein
103334

GHS危害和防范说明

GHS符号

Hazard Statements
H227-H314-H318
Combustible liquid.Causes severe skin burns and eye damage.Causes serious eye damage.

Precautionary Statements
P210e-P260h-P303+P361+P353-P305+P351+P338-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
34
Causes burns.

安全等级
26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

欧盟危险品标志

TSCA

C25139Alfa Aesar1-Amino-4-methylpiperazine99%1030元/25g;   3516元/100g;   展开

基本信息

Ref#
25139

MDL
6154

分子式
C5 H13 N3

分子量
115.18

闪点
62

密度
0.95

255688Sigma-Aldrich1-Amino-4-methylpiperazine97%566.93元/25 G;   展开

产品说明

应用

1-氨基-4-甲基哌嗪已被用于:

  • 吡唑并吡嗪、吡啶衍生物 和 2-[(4-甲基哌嗪-1-基)亚氨基甲基] 苯酚的合成
  • 作为溶剂和稳定剂制备均匀的 Ag 纳米粒子 (<10nm)

包装

25 g in glass bottle

基本信息

经验(实验)分子式C5H13N3
分子量115.18
EC 号230-053-7
MDL编号MFCD00006154
PubChem化学物质编号24855473
NACRESNA.22

产品性质

质量水平100
测定97%
形式liquid
折射率n20/D 1.485 (lit.)
bp172-175 ℃ (lit.)
溶解性water: soluble
密度0.957 g/mL at 25 ℃ (lit.)
SMILES stringCN1CCN(N)CC1
InChI1S/C5H13N3/c1-7-2-4-8(6)5-3-7/h2-6H2,1H3
InChI keyRJWLLQWLBMJCFD-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)145.4 °F - closed cup
闪点(C)63 ℃ - closed cup
个人防护装备Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
240572Fluorochem4-Methylpiperazin-1-amine95%242元/5g;   836元/25g;   2200元/100g;   7634元/500g;   展开

基本信息

CAS Number6928-85-4
MDL NumberMFCD00006154
Boiling Point172-175℃
Density0.957

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H227: Combustible liquid
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
CAS号首数字顺序排列: 1 2 3 4 5 6 7 8 9