CAS 68489-09-8; ws-12

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CAS:

68489-09-8

分子式:

C₁₈H₂₇NO₂

分子量:

289.41

英文名称:

ws-12

(1R,2S,5R)-2-isopropyl-n-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide

用途:

WS-12 是 TRPM8 的激动剂，其 EC50 值为 39 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

W877814

MACKLIN

WS-12

98%

69元/100mg; 129元/250mg; 329元/1g; 1099元/5g; 3599元/25g;

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储存：2-8℃

W792552

MACKLIN

WS-12

10mM in DMSO

720元/1ml;

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储存：-20°C

W0519

Sigma-Aldrich

WS-12

≥98% (HPLC), powder

2380.93元/5 MG;

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产品说明

包装

5 mg in glass bottle

生化/生理作用

WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.
WS-12 is a high-affinity, selective TRPM8 (cold menthol receptor 1; CMR1) agonist. TRPM8 agonists induce a cooling sensation in sensory neurons and produce profound, mechanistically novel analgesia in chronic pain states such as neuropathic pain.

基本信息

经验(实验)分子式	C₁₈H₂₇NO₂
分子量	289.41
MDL编号	MFCD11100191
PubChem化学物质编号	329830423
NACRES	NA.25

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to off-white
溶解性	DMSO: >20 mg/mL
储存温度	−20℃
SMILES string	COc1ccc(NC(=O)C2C[C@H](C)CC[C@H]2C(C)C)cc1
InChI	1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16?,17?/m1/s1
InChI key	HNSGVPAAXJJOPQ-NVPAJSRCSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H410
预防措施声明	P273 - P391 - P501
危险分类	Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

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