CAS 68476-36-8; globulins, blood plasma

CAS:

68476-36-8

英文名称:

globulins, blood plasma

用途:

Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

G921678

MACKLIN

Gc-球蛋白来源于人类血浆

≥90% (SDS-PAGE)

2486元/1mg;

展开

储存：−20°C
状态：固体

G8764

Sigma-Aldrich

Gc-globulin from human plasma

≥90% (SDS-PAGE), lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)

3107.5元/1 MG;

展开

产品说明

一般描述

Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Gc-globulin or the vitamin D binding protein (DBP) is a 51-58 kDa multifunctional serum glycoprotein synthesized in large quantities by primarily in the liver. It is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.

应用

Gc-globulin from human plasma has been used:

as a fluorescent probe for G-actin staining
as a fluorescent probe to monitor steady-state rate of actin filament disassembly
as a calibrator for liquid chromatography with mass spectrometry (LC-MS/MS)

Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions. It has been used to anlayze its glycosylation patterns.

生化/生理作用

Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].

制备说明

Native Gc-globulin from human plasma

基本信息

MDL编号	MFCD00131143
NACRES	NA.61

产品性质

质量水平	200
生物来源	human plasma
测定	≥90% (SDS-PAGE)
形式	lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
分子量	~52 kDa
technique(s)	LC/MS: suitable
溶解性	H₂O: soluble 2 mg/mL
UniProt登记号	P02774
储存温度	−20℃
Gene Information	human ... GC(2638)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

G3637

Sigma-Aldrich

Globulins Cohn fraction IV-4 human

2931.22元/5 G;

展开

产品说明

一般描述

Cohn fraction IV consists of α and β-globulins. It is a plasma by-product produced during γ-globulin synthesis.

应用

Globulins Cohn fraction IV-4 human has been used in differential scanning calorimetry (DSC) to test the effect of low-dose ionizing radiation. It has also been used in the preparation of plasma protein solution for biophysical studies.
Globulins may in binding of 5-methoxypsoralen to blood fractions.It may used as positive control for Granulocyte immunofluorescence test (GIFT). It may also used to study the thermal denaturation of mixtures of human serum proteins.

包装

5 g in poly bottle

生化/生理作用

The Cohn fraction IV (α-globin enriched) mediates the inhibition of brain neurotransmitter receptors.

其他说明

Predominantly α- and β-globulins

基本信息

EC 号	270-678-2
MDL编号	MFCD01114242
NACRES	NA.61

产品性质

质量水平	200
生物来源	human
形式	powder
溶解性	H₂O: soluble 50 mg/mL
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

G2388

Sigma-Aldrich

Globulins Cohn fraction II, III human

lyophilized powder

13094.4元/10 G;

展开

产品说明

应用

Globulins Cohn fraction II, III human has been used to replace α and β subunits to determine the role of α and β subunits of phosphorylase kinase.

包装

10 g in poly bottle

其他说明

主要为 γ- 和 β-球蛋白

外形

含有 NaCl

基本信息

EC 号	270-678-2
MDL编号	MFCD01114254
NACRES	NA.61

产品性质

质量水平	300
生物来源	human
测定	60-85% (biuret)
形式	lyophilized powder
组成	Protein, 60-85% TCA-Biuret
杂质	HIV 1 and 2, HBsAg and HCV, source material tested negative
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9