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位置：首页 > 资料中心 > 化工字典 > 68-94-0
关键词:       仅模糊查询
CAS: 68-94-0
分子式: C5H4N4O
分子量: 136.11
熔点: >300 °C(lit.)
中文名称: 
次黄碱
6-氧嘌呤
6-羟基嘌呤(次黄嘌呤)
6-羟基嘌呤
次黄嘌呤
1,7-二氢-6H-嘌呤-6-酮
英文名称: 
6H-Purin-6-one,1,7-dihydro-
Hypoxathine
1,7-dihydro-6H-Purin-6-one
6-Hydropurine
1,7-dihydro-6h-purin-6-one
6(1h)-purinone
6-hydroxypurine
6-oxopurine
1,7-dihydro-6h-purin-6-on
9h-purin-6-ol
hx
hypoxanthine
hypoxanthine enol
purin-6(3h)-one
purin-6-ol
sarcine
sarkin
sarkine
展开更多英文名
性质描述: 针状结晶。熔点>360℃。
生产方法: 氰乙酸乙酯与乙醇钠、硫脲经环合反应得到2-巯基-4-氨基-6-羟基嘧啶，再经亚硝化、还原、消除、环合，制得6-羟基嘌呤。
用途: 抗恶性肿瘤药6-巯嘌呤的中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
H796952MACKLIN次黄嘌呤10mM in DMSO125元/1ml;   展开
储存：-20°C
状态：液体
767952MACKLIN次黄嘌呤2mM in DMSO125元/1ml;   展开
储存：-20°C
H811076MACKLIN次黄嘌呤99%32元/5g;   51元/25g;   112元/100g;   339元/500g;   1499元/2.5kg;   展开
储存：室温
状态：白色到淡奶油色粉末
H6263MACKLIN次黄嘌呤(6-羟基嘌呤)99%生物技术级45元/10g;   114元/50g;   216元/100g;   766元/500g;   2458元/2.5kg;   展开
储存：室温
状态：白色到淡奶油色粉末
H0311TCIHypoxanthine>98.0%(E)(HPLC)190元/5G;   610元/25G;   展开

基本信息

纯度/分析方法>98.0%(E)(HPLC)
分子式/分子量C5H4N4O = 136.11
外观与形状(20℃)固体
Reaxys-RN608599
PubChem物质ID87570733
SDBS (AIST Spectral DB)1080
Merck Index (14)4869
MDL编号MFCD00005725

技术规格

AppearanceWhite to Light yellow to Light red powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(UV-vis method)98.0 to 104.0 %
Lambda max.247.0 to 251.0 nm(pH 7.0 buffer sol.)

相关法规

RTECS#UP0791000
462785J&KHypoxanthine98%60元/5G;   184元/25G;   607元/100G;   展开

基本信息

分子式C5H4N4O
分子量136.11
熔点>250
MDL编码MFCD00005725
Beilstein5811
Merck14,4869
EINECS 编号200-697-3

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
H335
防范说明P261
P280
P301+P312
P302+P352
P305+P351+P338
WGK3
RTECSUP0791000
TSCA是
930129J&KHypoxanthine99%126元/5G;   503元/25G;   1659元/100G;   展开

基本信息

分子式C5H4N4O
分子量136.11
熔点>250
MDL编码MFCD00005725
Beilstein5811
Merck14,4869
EINECS 编号200-697-3

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
H335
防范说明P261
P280
P301+P312
P302+P352
P305+P351+P338
WGK3
RTECSUP0791000
TSCA是
A11481Alfa AesarHypoxanthine99%293元/5g;   977元/25g;   3165元/100g;   展开

应用
Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. The compound has been used in studies as in indicator, along with uric acid and allantoin , of in vivo free radical reactions. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol ?￥ (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.

备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible to Strong oxidizing agents. Stable under recommended storage conditions. Sterilize by filtration through a 0.22 μm filter.

基本信息

MDL
MFCD00005725

EINECS
200-697-3

分子式
C5H4N4O

分子量
136.11

熔点
>300°

灵敏度
Keep Cold.

形态
Powder

溶解性
It does not mix appreciably with water (1:1400). Small octahedra crystals from water.

Beilstein
5811

Merck
14,4869

安全信息

RTECS
UP0791000

TSCA
是

H9377Sigma-AldrichHypoxanthine≥99.0%631.53元/1 G;   802.06元/5 G;   1299.04元/25 G;   4112.95元/100 G;   展开

产品说明

应用

次黄嘌呤是一种营养添加剂，适用于细菌、寄生虫(恶性疟原虫)和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。
Hypoxanthine has been used:

  • to gavage mice and to evaluate the activity of xanthine oxidase (XO) in pasteurized whole milk in vivo in potassium oxonate (PO) -induced mouse model of hyperuricemia
  • as a supplement in Iscove′s modified Dulbecco′s medium (IMDM) medium to cultivate in-vitro cell line (EL-1 cells)
  • as a pure standard for the quantification of hypoxanthine in vitreous fluid sample using high-performance liquid chromatography-ultra-violet (HPLC-UV) for the estimation of post-mortem interval

包装

1, 5, 25, 100 g in poly bottle

生化/生理作用

Hypoxanthine acts as an intermediate in purine metabolism. It elicits a vital role as a 5′-base of the anticodon in a few transfer-RNAs. Though similar to guanine (Gua), it is devoid of the exocyclic amino group at C(2) position. It may be used as a substrate to study the specificity and kinetics of hypoxanthine-guanine phosphoribosyl transferases.

基本信息

经验(实验)分子式C5H4N4O
分子量136.11
Beilstein5811
EC 号200-697-3
MDL编号MFCD00005725
PubChem化学物质编号24895850
NACRESNA.51

产品性质

质量水平300
200
生物来源synthetic (organic)
测定≥99.0%
形式powder
mp>300 ℃ (lit.)
溶解性formic acid: water (2:1): 50 mg/mL, clear to slightly hazy, colorless to yellow
SMILES stringO=C1NC=Nc2nc[nH]c12
InChI1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI keyFDGQSTZJBFJUBT-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
H9636Sigma-AldrichHypoxanthinepowder, BioReagent, suitable for cell culture317.53元/1 G;   500.59元/5 G;   1595.56元/25 G;   展开

产品说明

一般描述

次黄嘌呤(6-羟嘌呤)，一种嘌呤衍生物，是天然化合物。它是腺嘌呤的脱氨基形式，也是一磷酸腺苷(AMP)的分解产物。

应用

次黄嘌呤是一种营养添加剂，适用于细菌、寄生虫(恶性疟原虫)和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。
次黄嘌呤已被用于：

  • 作为HEPES (4-(2-羟乙基)-1-哌嗪乙烷磺酸) -buffered Roswell park memorial institute (RPMI)补充剂，培养镰状疟原虫菌株IT/FCR3
  • 制备Dulbecco′改性′s培养基 (DMEM) + MXH，用于选择嵌合修饰痘苗病毒安卡拉株(MVA)
  • 产生超氧阴离子
  • 用于制备杂交瘤选择和维持培养基。

包装

1, 5, 25 g in poly bottle

生化/生理作用

次黄嘌呤能够刺激细胞死亡。它也能诱导活性氧(ROS)。通过氧化应激刺激细胞凋亡可导致内皮功能障碍。

基本信息

经验(实验)分子式C5H4N4O
分子量136.11
Beilstein5811
EC 号200-697-3
MDL编号MFCD00005725
PubChem化学物质编号24895864
NACRESNA.75

产品性质

质量水平200
产品线BioReagent
测定≥99%
形式powder
technique(s)cell culture | mammalian: suitable
mp>300 ℃ (lit.)
溶解性formic acid: water (2:1): 50 mg/mL
web metadata keyword.defaulthybridoma selection agent, IMP salvage pathway, inositol monophosphate, IMP precursor, Hypoxanthine-guanine phosphoribosyltransferase
SMILES stringO=C1NC=Nc2nc[nH]c12
InChI1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI keyFDGQSTZJBFJUBT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
V900452Sigma-AldrichHypoxanthineVetec™, reagent grade, 98%79.94元/5 G;   115.9元/25 G;   展开

产品说明

应用

次黄嘌呤是一种营养添加剂，适用于细菌、寄生虫(恶性疟原虫)和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。

包装

5, 25 g in poly bottle

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

经验(实验)分子式C5H4N4O
分子量136.11
Beilstein5811
EC 号200-697-3
MDL编号MFCD00005725
PubChem化学物质编号329829854

产品性质

等级reagent grade
产品线Vetec™
测定98%
形式powder
mp>300 ℃ (lit.)
溶解性formic acid: water (2:1): 50 mg/mL, clear to slightly hazy
SMILES stringO=C1NC=Nc2nc[nH]c12
InChI1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI keyFDGQSTZJBFJUBT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0000441Didanosine impurity A,European Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

次黄嘌呤是一种营养添加剂，适用于细菌、寄生虫(恶性疟原虫)和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C5H4N4O
分子量136.11
Beilstein5811
MDL编号MFCD00005725
PubChem化学物质编号329830958
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp>300 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringO=C1NC=Nc2nc[nH]c12
InChI1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI keyFDGQSTZJBFJUBT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0002147Mercaptopurine impurity ACRS, European Pharmacopoeia (EP) Reference Standard1295.6元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

次黄嘌呤是一种营养添加剂，适用于细菌、寄生虫(恶性疟原虫)和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。

包装

Unit quantity: 15 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C5H4N4O
分子量136.11
Beilstein5811
MDL编号MFCD00005725

产品性质

manufacturer/tradenameEDQM
mp>300 ℃ (lit.)
储存温度2-8℃
SMILES stringO=C1NC=Nc2nc[nH]c12
InChI1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI keyFDGQSTZJBFJUBT-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
4010CBCMilliporeHypoxanthine-CAS 68-94-0-CalbiochemXanthine oxidase substrate.856.57元/25 G;   展开

产品说明

一般描述

Please note: this product is the same product that was previously found using Cat. No. 4010. Only the base catalog number has been changed.
Xanthine oxidase substrate. A product of nucleic acid breakdown. Acts to salvage free purines for nucleic acid and nucleotide recycling. Used in conjunction with thymidine and aminopterin for cloning and selection of hybridoma cell lines.
Xanthine oxidase substrate. Formed in the animal body during nucleic acid breakdown. Acts to salvage free purines for nucleic acid and nucleotide recycling. Used in conjunction with thymidine and aminopterin for cloning and selection of hybridoma cell lines.

包装

25 g in Glass bottle

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, sterilize by filtration through a 0.22 µm filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C5H4N4O
分子量136.11
MDL编号MFCD00005725

产品性质

质量水平100
测定≥99% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 white to off-white
溶解性1 M HCl: 20 mg/mL, clear (faint color solution)
DMF: 5 mg/mL, cloudy (with particulates)
DMSO: 5 mg/mL, clear, colorless (with few particulates)
hydrogen: 5 mg/mL, cloudy (with particulates)
痕量阳离子heavy metals: ≤10 ppm
运输ambient
储存温度15-25℃
InChI1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI keyFDGQSTZJBFJUBT-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1191226USPDidanosine Related Compound AUnited States Pharmacopeia (USP) Reference Standard11011.4元/25 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

应用

次黄嘌呤是一种营养添加剂，适用于细菌、寄生虫(恶性疟原虫)和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C5H4N4O
分子量136.11
Beilstein5811
MDL编号MFCD00005725
PubChem化学物质编号329749573
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp>300 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringO=C1NC=Nc2nc[nH]c12
InChI1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI keyFDGQSTZJBFJUBT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
948529AmethystHypoxanthine98%, 用于生化40元/5G;   58元/25G;   118元/100G;   展开

基本信息

分子式C5H4N4O
分子量136.11
熔点>250
MDL编码MFCD00005725
Beilstein5811
Merck14,4869
EINECS 编号200-697-3

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
H335
防范说明P261
P280
P301+P312
P302+P352
P305+P351+P338
WGK3
RTECSUP0791000
TSCA是
M01853FluorochemHypoxanthine, 99%98%286元/100g;   展开

基本信息

CAS Number68-94-0
MDL NumberMFCD00005725
Melting Point300 ℃

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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