CAS 671-35-2; 5-氟-4-羟基嘧啶; 5-fluoro-4(1h)-pyrimidinon

CAS:

671-35-2

分子式:

C4H3FN2O

分子量:

114.080

中文名称:

5-氟-4-羟基嘧啶

5-氟嘧啶醇

富雪定

英文名称:

5-fluoro-4(1h)-pyrimidinon

4-hydroxy-5-fluorpyrimidin

5-fluor-4-pyrimidinol

5-fluoro-4(1h)-pyrimidinone

fluoxidine

fluoxydine

5-Fluoro-4-hydroxypyrimidine

Fluoxydin

性质描述:

白色鳞片状结晶，熔点203-204℃。易溶于水，碱性溶液，溶于乙酸，热乙醇，不溶于乙醇，丙酮，氯仿，乙醚。

生产方法:

由氟乙酸乙酯经缩合反应而得。将甲醇钠加入干燥的反应锅内，加甲酸乙酯除去甲醇钠中的游离碱。搅拌下常压蒸出甲醇，然后减压蒸馏，直至甲醇钠成为白色粉末，降温至50℃，加入甲苯。再降至10℃下，滴加甲酸乙酯。加完后仍保持10℃以下滴加氟乙酸乙酯，加毕，在20-25℃反应7h，然后降至10℃以下，加入无水甲醇及乙酸甲脒，搅拌至反应物固化，静置过夜。加入盐酸，慢慢加热使固化物溶解。过滤，滤液常压蒸去部分液体，冷却结晶，过滤得到粗品。用无水乙醇重结晶，活性炭脱色，即得5-氟-4-羟基嘧啶。

用途:

该品为抗肿瘤药物。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

266163

J&K

5-Fluoro-4-hydroxypyrimidine

98%

250元/1G;

咨询

基本信息

分子式	C₄H₃FN₂O
分子量	114.08
熔点	203-205
MDL编码	MFCD00223674

安全信息

图形或危害标志
提示语	Warning
危险说明	H315 H319 H335
防范说明	P280 P305+P351+P338

079975

Fluorochem

5-Fluoro-4-hydroxypyrimidine

95%

1320元/5g; 4136元/100g;

咨询

基本信息

CAS Number	671-35-2
MDL Number	MFCD00223674

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H332: Harmful if inhaled. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .