CAS 66898-62-2; 他尼氟酯; 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinic aci phthalidyl ester

CAS:

66898-62-2

分子式:

C12H13F3N2O4

分子量:

261.50

熔点:

166-170°C

中文名称:

他尼氟酯

2-[(3-三氟甲基)苯基]氨基-3-吡啶羧酸苯酞酯

英文名称:

2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinic aci phthalidyl ester

2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinic acid phthalidyl ester

3-ftalidilico del acido 2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilic

3-phthalidyl ester of 2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxyl

ba 7602-06

phthalidyl 2-(3-trifluoromethylanilino)nicotinate

phthalidyl 2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate

somalgen

talniflumate

talniflumato

性质描述:

该品为白色至淡黄色结晶性粉末。

用途:

该品为非甾体消炎镇痛原料药，同时可用于纤维性囊肿和哮喘的辅助治疗。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

T868263

MACKLIN

他尼氟酯

≥98%

189元/50mg; 458元/200mg;

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储存：2-8°C
状态：白色到米黄色粉末

T796335

MACKLIN

他尼氟酯

10mM in DMSO

698元/1ml;

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储存：-20°C

T3101

TCI

Talniflumate

>98.0%(HPLC)(N)

760元/200MG; 2190元/1G;

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基本信息

纯度/分析方法	>98.0%(HPLC)(N)
分子式/分子量	C₂₁H₁₃F₃N₂O₄ = 414.34
外观与形状(20℃)	固体
储存温度	0-10℃
应避免的情况	加热
包装和容器	1G-带有塑料内管的玻璃瓶 (查看图片)
Reaxys-RN	503261
PubChem物质ID	253662062
Merck Index (14)	9044
MDL编号	MFCD00866135

技术规格

Appearance	Light orange to Yellow to Green powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 98.0 %
Melting point	166.0 to 170.0 ℃

物性(参考值)

熔点	168 ℃
最大吸收波长	287(CHCl3) nm

相关法规

RTECS#

QT2999200

SML1710

Sigma-Aldrich

Talniflumate

≥98% (HPLC)

1166.16元/5 MG; 4725.14元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Talniflumate is an orally available, potent and selective inhibitor of core mucin-synthesizing enzyme GCNT3 (core 2 b-1,6 N-acetylglucosaminyltransferase). Talniflumate decreases GCNT3 expression and production of mucins in vivo and in vitro. Talniflumate improves responsiveness of pancreatic tumors to gefitinib. Talniflumate is a potent calcium-activated chloride channel (CaCC) blocker.
Talniflumate is a phthalidyl ester of niflumic acid. It acts as an anti-inflammatory molecule and a mucoregulator. Talniflumate is used as a potent therapeutic for cystic fibrosis, chronic obstructive pulmonary disease and asthma. Talniflumate also inhibits the calcium-activated chloride channel hCLCA function, which is involved in mucus overproduction.

基本信息

经验(实验)分子式	C₂₁H₁₃F₃N₂O₄
分子量	414.33

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	room temp
InChI	1S/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26)
InChI key	ANMLJLFWUCQGKZ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable