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CAS: 665-66-7
分子式: C10H17N·HCl
分子量: 187.71
熔点: 300℃
中文名称: 
金刚烷胺盐酸盐
1-金刚烷胺-盐酸盐
盐酸金刚烷胺
金刚烷胺(盐酸)
1-金刚胺盐酸盐
英文名称: 
1-adamantanamine, hydrochloride
1-adamantanamine hydrochloride
1-adamantylamine hydrochloride
1-aminoadamantene hydrochloride
adamantanamine hydrochloride
adamantine hydrochloride
adamantylamine hydrochloride
amantadine hydrochloride
aminoadamantane hydrochloride
exp 105-1
midantane
mydantane
nsc 83653
symmetrel
tricyclo(3.3.1.1(sup 3,7))decan-1-amine, hydrochloride
tricyclo[3.3.1.13,7]decan-1-amine, hydrochloride
virasol
virofral
1-Aminoadamantane hydrochloride
展开更多英文名
性质描述: 白色结晶性粉末。熔点>360℃(分解)。易溶于水,微溶于乙醇,极微溶于丙酮,不溶于苯和乙醚。无臭,味苦。
生产方法: 由金刚烷胺成盐,精制而得。在搪玻璃中加入金刚烷胺、蒸馏水及活性炭。加盐酸调节至pH至3-5,加热至70℃溶解脱色半小时,冷却至室温,过滤。滤液抽入减压浓缩罐,在(14.7kPa)浓缩至呈粥状,自然冷却,过滤。加丙酮浸泡翻洗至pH5左右,滤干,在70℃干燥,得金刚烷胺盐酸盐。
用途: 抗病毒药,属窄谱类,仅用于防治A2型病毒引起的流行性感冒。该品阻止病毒穿入宿主细胞,并影响病毒的脱壳,达到抑制病毒增殖作用。该品作为抗震颤麻痹药。可促进多巴胺释放。
推荐供应商
货号品牌产品名称规格包装、参考价格
A795466MACKLIN盐酸金刚烷胺10mM in DMSO980元/1ml;   咨询
储存:-20°C
A800770MACKLIN盐酸金刚烷胺99%30元/25g;   46元/100g;   155元/500g;   757元/2.5kg;   咨询
储存:室温,干燥,密封
状态:白色到灰白色粉末或晶体
A0588TCI1-Adamantanamine Hydrochloride>99.0%(T)460元/25G;   1090元/250G;   咨询

基本信息

纯度/分析方法>99.0%(T)
分子式/分子量C10H17N・HCl = 187.71
外观与形状(20℃)固体
相关CAS RN768-94-5
Reaxys-RN4198854
PubChem物质ID87562172
MDL编号MFCD00074723

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(Nonaqueous Titration)min. 99.0 %
Purity(Argentometric Titration)min. 99.0 %
Solubility in Wateralmost transparency

物性(参考值)

熔点360 ℃

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#AU4375000
407698J&K1-Adamantanamine Hydrochloride99%, 抗流感病毒和抗帕金森病化合物89元/5G;   353元/25G;   428元/100G;   咨询

基本信息

分子式C10H17N·HCl
分子量187.71
熔点>300
MDL编码MFCD00074723
Beilstein4198854
Merck14,374
EINECS 编号211-560-2

产品描述

Amantadine HCl用于治疗或预防某些病毒引起的呼吸道感染。

靶点(IC50 & Targe)

Dopamine

安全信息

图形或危害标志
提示语Warning
危险说明H302
防范说明P264
P270
P301+P312
P330
P501
WGK3
RTECSAU4375000
TSCA
A12699Alfa Aesar1-Adamantanamine Hydrochloride99%1407元/25g;   2649元/100g;   11242元/500g;   咨询

应用
1-Adamantanamine hydrochloride is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extra pyramidal reactions, and for postherpetic neuralgia. It is also used an NMDA-receptor antagoinst.

备注
Hygroscopic. Store in cool dry place in tightly closed container. With good ventilation. Store away from oxidizing agent and water/moisture.

基本信息

MDL
MFCD00074723

EINECS
211-560-2

分子式
C10H17N?HCl

分子量
187.71

熔点
360°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water (50 mg/ml), ethanol (38 mg/ml at 25°C), chloroform (1:18), DMSO (38 mg/ml at 25°C), and methanol

Beilstein
4198854

Merck
14,374

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H361
Harmful if swallowed.Suspected of damaging fertility or the unborn child.

Precautionary Statements
P201-P280-P301+P312a-P308+P313-P405-P501a
Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Wear protective gloves/protective clothing/eye protection/face protection.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22-63
Harmful if swallowed.Possible risk of harm to the unborn child.

安全等级
36/37
Wear suitable protective clothing and gloves.

欧盟危险品标志

RTECS
AU4375000

TSCA

C15167Alfa Aesar1-Adamantanamine Hydrochloride99+%1993元/25g;   5075元/100g;   咨询

基本信息

Ref#
15167

MDL
74723

分子式
C10 H17 N . H Cl

分子量
187.71

R10997Alfa Aesar1-Adamantanamine hydrochloride Standard solution100ppm210元/1ml;   咨询

安全信息

危险等级
3

A1260Sigma-AldrichAmantadine Hydrochloride802.97元/5 G;   3137.74元/25 G;   6430.41元/100 G;   咨询

产品说明

一般描述

盐酸金刚烷胺{三环-[3,3,1,1]- deean-l-胺盐酸盐是一种以盐酸金刚乙胺为类似物的药物。

应用

使用盐酸金刚烷胺:

  • 测定其在缓解手术引起的认知障碍方面的有效性
  • 预培养多能干细胞(MSC)并研究细胞内化途径
  • 确定金刚烷减毒脓毒症是否会诱发神经炎症和学习记忆功能障碍
  • 预培养原代培养大鼠牙髓干细胞(rDPSC)
  • 确定内化途径

包装

5, 25, 100 g in poly bottle

生化/生理作用

盐酸金刚烷胺在体内体外均对流感病毒有效。它还可作为N-甲基-D-天冬氨酸(NMDA)型谷氨酸受体的拮抗剂。金刚烷胺在多巴胺的释放中起着重要的作用,用于阻止多巴胺的再摄取并阻断小胶质细胞激活和神经炎症。
多巴胺释放剂用于治疗帕金森综合征和药物引起的锥体外系反应。

特点和优势

该化合物是 ADME Tox research 的特色产品。单击此处可发现更多ADME Tox 产品。前往sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
该化合物由 Endo 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表,请点击这里。

基本信息

经验(实验)分子式C10H17N · HCl
分子量187.71
Beilstein4198854
EC 号211-560-2
MDL编号MFCD00074723
PubChem化学物质编号24277882
NACRESNA.77

产品性质

质量水平100
溶解性H2O: 50 mg/mL
ethanol: soluble
创始人Endo
SMILES stringCl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
InChI1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI keyWOLHOYHSEKDWQH-SOVZANNPSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
A0363000Amantadine HydrochlorideEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

多巴胺释放剂用于治疗帕金森综合征和药物引起的锥体外系反应。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C10H17N · HCl
分子量187.71
Beilstein4198854
MDL编号MFCD00074723
PubChem化学物质编号329770607
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
InChI1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI keyWOLHOYHSEKDWQH-SOVZANNPSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1018505USPAmantadine HydrochlorideUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

多巴胺释放剂用于治疗帕金森综合征和药物引起的锥体外系反应。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C10H17N · HCl
分子量187.71
Beilstein4198854
MDL编号MFCD00074723
PubChem化学物质编号329748968
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
InChI1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI keyWOLHOYHSEKDWQH-SOVZANNPSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码8B - Non-combustible, corrosive hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
8.20015Sigma-Aldrich1-Adamantaneammonium chloridefor synthesis607.56元/10 G;   2153.27元/50 G;   咨询

产品说明

分析说明

Assay (argentometric): ≥ 99.0 %
Identity (IR): passes test

基本信息

经验(实验)分子式C10H18ClN
分子量187.71
MDL编号MFCD00074723
EC索引号211-560-2

产品性质

质量水平200
效能800 mg/kg LD50, oral (Rat)
mp360 ℃
储存温度2-30℃
InChI1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI keyWOLHOYHSEKDWQH-SOVZANNPSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHR1711SupelcoAmantadine HydrochloridePharmaceutical Secondary Standard; Certified Reference Material1518.26元/500 MG;   咨询

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

多巴胺释放剂用于治疗帕金森综合征和药物引起的锥体外系反应。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3167 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C10H17N · HCl
分子量187.71
Beilstein4198854
EC 号211-560-2
MDL编号MFCD00074723
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
形式powder
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
application(s)pharmaceutical
药典可追溯性traceable to BP 530
traceable to PhEur A0363000
traceable to USP 1018505
储存温度2-30℃
SMILES stringCl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
InChI1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI keyWOLHOYHSEKDWQH-SOVZANNPSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP530Amantadine HydrochlorideBritish Pharmacopoeia (BP) Reference Standard2144.18元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

多巴胺释放剂用于治疗帕金森综合征和药物引起的锥体外系反应。

包装

Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C10H17N · HCl
分子量187.71
Beilstein4198854
MDL编号MFCD00074723
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringCl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
InChI1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI keyWOLHOYHSEKDWQH-SOVZANNPSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 + P330 - P501
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
981397Amethyst1-Adamantanamine Hydrochloride99%, 用于合成51元/5G;   64元/25G;   115元/100G;   313元/500G;   咨询

基本信息

分子式C10H17N·HCl
分子量187.71
熔点>300
MDL编码MFCD00074723
Beilstein4198854
Merck14,374
EINECS 编号211-560-2

安全信息

图形或危害标志
提示语Warning
危险说明H302
防范说明P264
P270
P301+P312
P330
P501
WGK3
RTECSAU4375000
TSCA
210024Fluorochem1-Adamantanamine Hydrochloride95%220元/25g;   396元/100g;   咨询

基本信息

CAS Number665-66-7
MDL NumberMFCD00074723
Melting Point360℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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