CAS 66357-59-3; ah 19065

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R838252

MACKLIN

盐酸雷尼替丁

98%,solid

50元/1g; 125元/5g; 375元/25g; 1280元/100g; 3747元/500g;

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储存：2-8°C
状态：灰白色到浅黄色粉末

R795611

MACKLIN

盐酸雷尼替丁

10mM in DMSO

820元/1ml;

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储存：-20°C

R0073

TCI

Ranitidine Hydrochloride

>98.0%(T)(HPLC)

465元/5G; 1090元/25G;

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基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₁₃H₂₂N₄O₃S・HCl = 350.86
外观与形状(20℃)	固体
储存温度	0-10℃
储存在惰性气体下	存放于惰性气体之中
应避免的情况	空气,加热
相关CAS RN	71130-06-8
Reaxys-RN	4342707
PubChem物质ID	87575630
Merck Index (14)	8110
MDL编号	MFCD00069339

技术规格

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %

物性(参考值)

熔点	135 ℃(dec.)

安全信息

信号词	警告
危险性说明	H303 : 吞咽可能有害。
防范说明	P312 : 如感觉不适，呼叫急救中心/医生。

相关法规

RTECS#

KM6557000

200704

J&K

Ranitidine Hydrochloride

98%, 一种组胺H2-受体拮抗剂, IC50为3.3 μM

266元/5G; 941元/25G;

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基本信息

分子式	C₁₃H₂₂N₄O₃S·HCl
分子量	350.86
MDL编码	MFCD00069339
Merck	14,8110
EINECS 编号	266-333-0

产品描述

Ranitidine是组胺H2-受体拮抗剂，IC50为3.3±1.4 μM。

靶点（IC50 & Targe）

H2 receptor

体外研究

Ranitidine使肝细胞从激活的中性粒细胞的毒性产物被杀死，而Famotidine缺乏这种能力。[1] Ranitidine抑制脂多糖体外刺激的单核细胞产生肿瘤坏死因子-α（TNF-α）。[2] 在分离的豚鼠肝细胞中，Ranitidine剂量依赖性地减少吗啡Kel，最大效应为50％，并增加吗啡-6-葡糖苷酸和吗啡-3-葡糖苷酸的相对浓度。Ranitidine逐渐减小吗啡-3-葡糖苷酸/吗啡-6-葡糖苷酸比高达21％。[3]

体内研究

在大鼠中，Ranitidine导致肝损伤，证据是6小时内增加的血清丙氨酸转氨酶，天冬氨酸转氨酶和γ-谷氨酰转移酶活性。[1] 在大鼠中，Ranitidine导致肝损伤，证据是6小时内增加的血清丙氨酸转氨酶，天冬氨酸转氨酶和γ-谷氨酰转移酶活性。[2] 在LPS/ RAN处理的大鼠中，Ranitidine在肝损伤之前增强LPS诱导的凝固，以及抗凝血剂减少肝损伤。在肝血窦的形成过程中，Ranitidine/LPS处理导致大鼠纤维蛋白凝块，并预防与减少的肝细胞损伤相关的纤维蛋白沉积。在大鼠中，Ranitidine在肝细胞损伤前增强LPS诱导的TNF的增加。[4] 在大鼠中，Ranitidine在高架十字迷宫中表现抗焦虑作用，表现在更多的时间留在开放臂上，更多的最终偏移。[5]

参考文献

[1] Luyendyk JP, et al. J Pharmacol Exp Ther,?003, 307(1), 9-16.

[2] Okajima K, et al. J Pharmacol Exp Ther,?002, 301(3), 1157-1165.

[3] Aasmundstad TA, et al. Pharmacol Toxicol, 1998, 82(6), 272-279.

[4] Tukov FF, et al. Toxicol Sci,?007, 100(1), 267-280.

[5] Privou C, et al. Neuropharmacology,?998, 37(8), 1019-1032.

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H410
防范说明	P264 P270 P273 P301+P312 P391 P501
UN号码	3077
危险分类	9
包装等级	III
WGK	2
RTECS	KM6557000
TSCA	否

B22260

Alfa Aesar

Ranitidine Hydrochloride

99%

630元/5g; 2328元/25g;

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应用
An H-2 histamine receptor antagonistRanitidine hydrochloride is mainly used as an H2-receptor antagonist and helps in the treatment of gastrointestinal lesions because of excessive gastric acid secretion. It also serves as an antiulcer drug.

备注
Light sensitive. Incompatible with oxidizing agents.

基本信息

MDL
MFCD00069339

EINECS
266-333-0

分子式
C₁₃H₂₂N₄O₃S?HCl

分子量
350.86

熔点
ca 134° dec.

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water, 2-hydroxypropyl-beta-cyclodextrin, acetic acid, methanol, ethanol and dimethyl sulfoxide. Insoluble in chloroform.

Merck
14,8110

GHS危害和防范说明

Hazard Statements
H303
May be harmful if swallowed.

安全信息

TSCA
否

R101

Sigma-Aldrich

Ranitidine Hydrochloride

solid

453.64元/1 G; 1112.6元/5 G;

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产品说明

应用

盐酸雷尼替丁已被用作开发和验证平行人工膜渗透性试验 (PAMPA) 的参考化合物。

包装

1, 5 g in poly bottle

生化/生理作用

雷尼替丁主要用于治疗非甾体类抗炎药 (NSAID) 引起的胃肠道损害。
H₂ 组胺受体拮抗剂；抗溃疡剂。

特点和优势

该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
该化合物出现在受体分类和信号转导手册的组胺受体页。欲浏览其他手册页面，请点击此处。

基本信息

经验(实验)分子式	C₁₃H₂₂N₄O₃S · HCl
分子量	350.86
EC 号	266-333-0
MDL编号	MFCD00069339
PubChem化学物质编号	24277803
NACRES	NA.77

产品性质

质量水平	200
形式	solid
颜色	tan
溶解性	H₂O: 1.8 mg/mL 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL
创始人	GlaxoSmithKline
SMILES string	Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI	1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key	GGWBHVILAJZWKJ-CHHCPSLASA-N
Gene Information	human ... HRH2(3274)

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H317 - H319 - H334 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

R0150000

Ranitidine Hydrochloride

European Pharmacopoeia (EP) Reference Standard

1277.32元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

H₂ 组胺受体拮抗剂；抗溃疡剂。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₃H₂₂N₄O₃S · HCl
分子量	350.86
MDL编号	MFCD00069339
PubChem化学物质编号	329823974
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI	1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key	GGWBHVILAJZWKJ-CHHCPSLASA-N

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H317 - H319 - H334 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

PHR1026

Supelco

Ranitidine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

1025.53元/500 MG;

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产品说明

一般描述

Ranitidine hydrochloride is a H₂-receptor antagonist, widely used for the management of hypersecretory conditions and for the treatment of duodenal ulcer.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Ranitidine hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using titrimetry and visible spectrophotometry techniques.

生化/生理作用

H2 histamine receptor antagonist; anti-ulcer agent.
H₂ 组胺受体拮抗剂；抗溃疡剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA5630 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₁₃H₂₂N₄O₃S · HCl
分子量	350.86
EC 号	266-333-0
MDL编号	MFCD00069339
PubChem化学物质编号	329823056
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to BP 471 traceable to PhEur R0150000 traceable to USP 1598405
储存温度	2-30℃
SMILES string	Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI	1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key	GGWBHVILAJZWKJ-CHHCPSLASA-N

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H317 - H319 - H334 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0001787

Ranitidine for impurity A identification

European Pharmacopoeia (EP) Reference Standard

1277.32元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

H₂ 组胺受体拮抗剂；抗溃疡剂。

包装

Unit quantity: 15mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₃H₂₂N₄O₃S · HCl
分子量	350.86
MDL编号	MFCD00069339
PubChem化学物质编号	329831573
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI	1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key	GGWBHVILAJZWKJ-CHHCPSLASA-N

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H317 - H319 - H334 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

1598405

USP

Ranitidine Hydrochloride

United States Pharmacopeia (USP) Reference Standard

3231.47元/200 MG;

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产品说明

一般描述

生化/生理作用

H₂ 组胺受体拮抗剂；抗溃疡剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₃H₂₂N₄O₃S · HCl
分子量	350.86
MDL编号	MFCD00069339
PubChem化学物质编号	329751022
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard secondary reference material (pharmaceutical)
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI	1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key	GGWBHVILAJZWKJ-CHHCPSLASA-N

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H317 - H319 - H334 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

BP471

Ranitidine Hydrochloride

British Pharmacopoeia (BP) Reference Standard

1952.55元/100 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

H₂ 组胺受体拮抗剂；抗溃疡剂。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₃H₂₂N₄O₃S · HCl
分子量	350.86
EC 号	266-333-0
MDL编号	MFCD00069339
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI	1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key	GGWBHVILAJZWKJ-CHHCPSLASA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

243895

Fluorochem

Noctone

95%

220元/500mg; 924元/5g; 2178元/25g;

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基本信息

CAS Number	66357-59-3
MDL Number	MFCD00069339