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货号

品牌

产品名称

规格

包装、参考价格

N795805

MACKLIN

尼莫地平

10mM in DMSO

367元/1ml;

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储存：-20°C

N837938

MACKLIN

尼莫地平

98 %

50元/1g; 104元/5g; 299元/25g; 850元/100g; 2378元/500g;

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储存：室温，干燥
状态：白色到浅黄色粉末到晶体

N0896

TCI

Nimodipine

>98.0%(HPLC)

870元/1G; 2050元/5G;

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基本信息

纯度/分析方法	>98.0%(HPLC)
分子式/分子量	C₂₁H₂₆N₂O₇ = 418.45
外观与形状(20℃)	固体
Reaxys-RN	459792
PubChem物质ID	135727105
Merck Index (14)	6551
MDL编号	MFCD00153848

技术规格

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Elemental analysis(Nitrogen)	6.55 to 6.80 %
Melting point	124.0 to 128.0 ℃

物性(参考值)

熔点	126 ℃
溶解性(可溶于)	甲醇

安全信息

信号词	警告
危险性说明	H303 : 吞咽可能有害。
防范说明	P312 : 如感觉不适，呼叫急救中心/医生。

相关法规

RTECS#

US7975500

488698

J&K

Nimodipine

99%, 一种钙离子通道阻断剂, 硝苯地平类似物

751元/1G; 1767元/5G;

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基本信息

分子式	C₂₁H₂₆N₂O₇
分子量	418.44
熔点	124-128
MDL编码	MFCD00153848
Beilstein	459792
Merck	14,6551
EINECS 编号	266-127-0
存储条件	Freezer -20℃

产品描述

Nimodipine是一种二氢吡啶衍生物，是钙离子通道抑制剂Nifedipine的类似物，具有降压活性。Nimodipine能减少细胞内游离Ca2+，Beclin-1及细胞自噬。

靶点（IC50 & Targe）

AhR

Calcium Channel

Mineralocorticoid Receptor

体外研究

Nimodipine以年龄和浓度依赖性减小峰值振幅和AHP在一个的综合区域。在衰老CA1区神经元，Nimodipine (100 nM)显著降低AHP。Nimodipine通过减少尖峰频率以年龄和浓度依赖性增加兴奋性（延长去极化电流注入期间增加动作电位的数量）。年轻神经元CA1区中，Nimodipine在较高浓度时减少适应性。[1] 在老化神经元和年轻大鼠神经元中，Nimodipine（浓度低至100 nM）降低钙AP的的的平台期。[2]

体内研究

Nimodipine抑制可逆的，剂量相关的听觉神经（CAP; N1-P1）的化合物动作电位，N1延迟在超阈值水平的延长，CAP的阈值的升高，在N1延迟以恒定振幅测量在CAP的阈值减少，在耳蜗微音（CM）的降低以及负总和电位（SP）的一个点的减少。[3] Nimodipine（10毫克/公斤，SC），一个L型的二氢吡啶钙通道拮抗剂，似乎完全阻止建立可卡因的作用调节，但只部分地阻挡可卡因致敏。[4] Nimodipine（5-20毫克/千克，SC）剂量相关性抑制鼻戳响应的方式的可卡因和吗啡的自我管理。[5]

参考文献

[1] Moyer JR Jr, et al. J Neurophysiol,?992, 68(6), 2100-2109.

[2] Moyer JR Jr, et al. Hippocampus,?994, 4(1), 11-17.

[3] Bobbin RP, et al. Hear Res,?990, 46(3), 277-287.

[4] Reimer AR, et al. Psychopharmacology (Berl),?994, 113(3-4), 404-410.

[5] Kuzmin A, et al. Pharmacol Biochem Behav,?992, 41(3), 497

安全信息

图形或危害标志
提示语	Warning
危险说明	H303
防范说明	P312
WGK	1
RTECS	US7975500

PHR1293

Supelco

Nimodipine

Pharmaceutical Secondary Standard; Certified Reference Material

1348.19元/1 G;

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产品说明

一般描述

Nimodipine is a well-known calcium antagonist and is a moderate cerebral vasodilator, in addition to being an inhibitor of cerebrovascular reactivity. It is suggested to be cytoprotective by causing a decrease in the influx of calcium into the nerve cells. It is accepted for use in the management of delayed ischaemic dysfunction and is commonlly used in the studies of brain function impairment and dementia in old age.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Nimodipine can be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations and combined dosage forms by various electrochemical and spectrophotometric techniques.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA0583 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₂₁H₂₆N₂O₇
分子量	418.44
EC 号	266-127-0
MDL编号	MFCD00153848
PubChem化学物质编号	329823284
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to BP 651 traceable to PhEur N0850000 traceable to USP 1463858
储存温度	2-8℃
SMILES string	COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
InChI	1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChI key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

N0850000

Nimodipine

European Pharmacopoeia (EP) Reference Standard

1259.15元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₁H₂₆N₂O₇
分子量	418.44
MDL编号	MFCD00153848
PubChem化学物质编号	329818466
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
InChI	1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChI key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

N149

Sigma-Aldrich

Nimodipine

1232.73元/100 MG; 3862.87元/500 MG;

咨询

产品说明

应用

尼莫地平已被用于：

作为L型钙通道(LTCC)的抑制剂，以评估其在振动切割中的神经保护活性
作为标准品，用于通过高效液相色谱(HPLC)对手性药物进行对映体分离
测量脊柱电压逃逸的药理学研究

包装

100, 500 mg in poly bottle

生化/生理作用

尼莫地平可增强黑质多巴胺能神经元的存活。
尼莫地平是一种有效的L型Ca²⁺ 通道拮抗剂。

特点和优势

该化合物出现在受体分类和信号转导手册的钙离子通道页。欲浏览其他手册页，点击此处。
该化合物由Bayer开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

注意

光敏性

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDF N149.pdf 中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息，请访问sigma.com/metlin。

基本信息

经验(实验)分子式	C₂₁H₂₆N₂O₇
分子量	418.44
EC 号	266-127-0
MDL编号	MFCD00153848
PubChem化学物质编号	24277858
NACRES	NA.77

产品性质

质量水平	200
测定	≥98% (HPLC)
形式	powder
颜色	off-white to yellow
溶解性	methanol: 62.5 mg/mL 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: insoluble H₂O: insoluble
创始人	Bayer
SMILES string	COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
InChI	1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChI key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Gene Information	human ... ADORA3(140), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNG1(786), NR3C2(4306) rat ... Adora1(29290), Adora2a(25369)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

BP651

Nimodipine

British Pharmacopoeia (BP) Reference Standard

2098.58元/100 MG;

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产品说明

一般描述

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₁H₂₆N₂O₇
分子量	418.44
EC 号	266-127-0
MDL编号	MFCD00153848
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
保质期	limited shelf life, expiry date on the label
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
InChI	1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChI key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

1463858

USP

Nimodipine

United States Pharmacopeia (USP) Reference Standard

3231.47元/125 MG;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₁H₂₆N₂O₇
分子量	418.44
MDL编号	MFCD00153848
PubChem化学物质编号	329750562
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
InChI	1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChI key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

482200

Sigma-Aldrich

Nimodipine-CAS 66085-59-4-Calbiochem

An L-type Ca²⁺ channel blocker.

820元/25 MG;

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产品说明

一般描述

An L-type Ca²⁺ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats.
An L-type Ca²⁺ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Also reported to block TNF-α and LPS-induced iNOS activity (IC₅₀ = 36 pM) in mouse astroglial cells.

包装

25 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Reversible: no
Primary Target
L-type Ca2⁺ channel blocker
Cell permeable: no
Target IC₅₀: 36 pM blocking TNF-α and LPS-induced iNOS activity in mouse astroglial cells

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Zhu, D., et al. 1999. Life. Sci.65, PL 221.
Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
Kappelle, A.C., et al. 1994. Br. J. Pharmacol.111, 887.
Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
Kappelle, A.C., et al. 1993. Br. J. Pharmacol.108, 780.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₁H₂₆N₂O₇
分子量	418.44
MDL编号	MFCD00153848

产品性质

质量水平	100
测定	>98% (TLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 25 mg/mL methanol: soluble
运输	ambient
储存温度	2-8℃
InChI	1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChI key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0001784

Nimodipine for peak identification

European Pharmacopoeia (EP) Reference Standard

1806.61元/ ;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 15mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₁H₂₆N₂O₇
分子量	418.44
MDL编号	MFCD00153848
PubChem化学物质编号	329831571
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
InChI	1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChI key	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), NR3C2(4306)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

M02160

Fluorochem

Nimodipine

>98%

726元/1g; 3410元/5g; 16808元/25g;

咨询

基本信息

CAS Number	66085-59-4
MDL Number	MFCD00153848
Melting Point	126℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .

HY-B0265

MCE

Nimodipine,66085-59-4,尼莫地平_MCE(MedChemExpress)

203元/10 mM * 1 mL in DMSO; 185元/25 mg; 278元/50 mg; 400元/100 mg; 546元/200 mg; 800元/500 mg;

咨询

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Nimodipine

MCE 国际站：Nimodipine

品牌：MedChemExpress (MCE)

货号：HY-B0265

CAS 号：66085-59-4

生物活性：尼莫地平（BAY-e 9736）是一种口服有效、耐受性良好且对光敏感的二氢吡啶类钙拮抗剂。尼莫地平可用于脑血管疾病的研究[1]。

体外研究(In Vitro)：Nimodipine (1.5~150 μg/ml; 15 minutes; B16a and W256 cells) results in a dose-dependent inhibition of B16a and W256 tumor-cell-induced platelet aggregation. Nimodipine is also inhibitory in a homologous system[3]. MCE尚未独立确认这些方法的准确性。仅供参考。

体内研究(In Vivo)：Nimodipine (0.2 μg/μl, intrathecal administration) prevents subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration[2]. Nimodipine(0.1~80 mg/kg; p.o.) results in a significant dose-dependent inhibition of spontaneous metastasis[3]. MCE尚未独立确认这些方法的准确性。仅供参考。

分子量：418.44

Formula：C21H26N2O7

性状：固体

颜色：Light yellow to yellow

中文名称：尼莫地平；硝苯比酯；硝苯甲氧乙基异丙啶

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式： 4°C，避光保存 *溶剂保存：-80°C，6个月；-20°C，1个月（避光保存）

文献引用：MCE 顾客使用本产品发表 21 篇科研文献

提供质量检测报告：Data Sheet、SDS、COA、LCMS、产品使用指南

产品活性：Nimodipine (BAY-e 9736) 是一种具有口服活性，耐受性良好的光敏二氢吡啶钙拮抗剂。Nimodipine 可以用于脑血管疾病的研究。

IC50 & Target：dihydropyridine calcium[1]

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客户发表文献：
[1]. Nature. 2026 Sep;657(8131):549-558.
[2]. Nature. 2026 Sep;657(8132):755-764.
[3]. Nature. 2026 Sep;657(8133):1027-1034.
[4]. Nature. 2026 Sep;657(8131):477-486.
[5].Nature. 2026 Sep;657(8132):789-799.
[6]. Nature. 2026 Sep;657(8131):517-524.
[7]. Nature. 2026 Sep;657(8133):1045-1052.
[8]. Cell. 2026 Sep 14:S0092-8674(26)01003-2.
[9]. Cell. 2026 Sep 3;189(18):5688-5705.e13.
[10]. Cell. 2026 Sep 2:S0092-8674(26)00937-2.

参考文献：
[1]. Langley, M.S., et al. Nimodipine. Drugs 37, 669–699 (1989).
[2]. Marbacher S, et al. Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo. Intensive Care Med. 2008;34(5):932-938.
[3]. Honn KV, et al. Inhibition of tumor cell-platelet interactions and tumor metastasis by the calcium channel blocker, nimodipine. Clin Exp Metastasis. 1984;2(1):61-72.

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