CAS 66-76-2; 双香豆素; dicumarol

CAS:

66-76-2

分子式:

C19H12O6

分子量:

336.30

熔点:

290-292℃

中文名称:

双香豆素

丁香素

3,3'-亚甲基双(4-羟基香豆素)

双苯并哌弄

双(羟)香豆素

甜金花素

英文名称:

dicumarol

dicumol

dufalone

dwukumarol

kumoran

melitoxin

nc 034

temparin

trombosan

3,3'-methylenebis(4-hydroxy-coumari

3,3'-methylenebis(4-hydroxy-2h-1-benzopyran-2-on

3,3'-methylenebis[4-hydroxy-2h-1-benzopyran-2-on

3,3'-methyleen-bis(4-hydroxy-cumarine)

3,3'-methyleen-bis(4-hydroxy-cumarine) (dutch)

3,3'-methylen-bis(4-hydroxy-cumarin)

3,3'-methylen-bis(4-hydroxy-cumarin) (german)

3,3'-methylene-bis(4-hydroxycoumarine)

3,3'-methylene-bis(4-hydroxycoumarine) (french)

3,3'-methylenebis(4-hydroxy-1,2-benzopyrone)

3,3'-methylenebis(4-hydroxy-2h-1-benzopyran-2-one)

3,3'-methylenebis(4-hydroxycoumarin)

3,3'-metilen-bis(4-idrossi-cumarina)

3,3'-metilen-bis(4-idrossi-cumarina) (italian)

4,4'-dihydroxy-3,3'-methylene bis coumarin

acadyl

acavyl

antitrombosin

baracoumin

bis(4-hydroxycoumarin-3-yl)methane

bis-3,3'-(4-hydroxycoumarinyl)methane

bishydroxycoumarin

cuma

cumid

di-(4-hydroxy-3-coumarinyl)methane

di-4-hydroxy-3,3'-methylenedicoumarin

dicoumal

dicoumarin

dicoumarol

dicuman

dicumaol r

dicumarine

展开更多英文名

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

D795357

MACKLIN

双香豆素

10mM in DMSO

648元/1ml;

展开

储存：-20°C
状态：液体

D837906

MACKLIN

双香豆素

99 %

94元/1g; 281元/5g; 935元/25g;

展开

储存：室温，干燥
状态：白色到浅黄色粉末

945745

J&K

Dicumarol

98%

300元/100MG;

展开

基本信息

分子式	C₁₉ H₁₂ O₆
分子量	336.29
MDL编码	MFCD00006857

287897

Sigma-Aldrich

Dicoumarol-CAS 66-76-2-Calbiochem

A cell-permeable quinone reductase inhibitor with anticoagulant properties.

1164.01元/500 MG;

展开

产品说明

一般描述

A cell-permeable quinone reductase inhibitor with anticoagulant properties. Potentiates apoptosis by simultaneously blocking SAPK/JNK and NF-κB pathways. Does not affect phosphorylation of p38 or activation of AKT. Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells (IC₅₀ = 180 µM and 150 µM, respectively).
A cell-permeable quinone reductase inhibitor with anti-coagulant properties. Binds competitively with NADH or NADPH to inhibit NAD(P)H:quinone oxidoreductase (NQO1). Shown to inhibit IGF-I-, menadione-, and DMNQ-mediated activation of stress-activated protein kinase/c-jun NH2-terminal kinase (SAPK/JNK) and subsequent phosphorylation of c-Jun, as well as stress-induced activation (hypertonic sorbitol) of SAPK/JNK. Does not affect p38 phosphorylation or protein kinase B (AKT) activation. Also shown to induce apoptosis in MCF7 breast carcinoma cells. Inhibits glutathione-S transferase (GST) A1-1 enzyme (K_iu = 4.4 µM, K_ic = 3.6 µM) in vitro and in MCF7/VPα cells (a multidrug resistant derivative of MCF7 transfected with GST A1-1). Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells (IC₅₀ = 180 µM and 150 µM, respectively).

包装

500 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Target IC₅₀: 180 µM and 150 µM in blocking brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells, respectively
Primary Target
Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro
Product does not compete with ATP.
Cell permeable: yes
Reversible: no

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

重悬

Unstable in solution; reconstitute just prior to use.

其他说明

Seanor, K.L., et al. 2003. Antioxid. Redox. Signal5, 103.
Krause, D., et al. 2001. J. Biol. Chem.276, 19244.
Pink, J.J., et al. 2000. J. Biol. Chem.275, 5416.
Cross, J.V., et al. 1999. J. Biol. Chem.274, 31150.
Morrow, C.S., et al. 1998. J. Biol. Chem.273, 20114.
Weigert, R., et al. 1997. J. Biol. Chem.272, 14200.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₉H₁₂O₆
分子量	336.29
MDL编号	MFCD00006857

产品性质

质量水平	100
测定	≥98% (titration)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	0.1 M NaOH: 15 mg/mL pyridine: 50 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H372 - H411
预防措施声明	P260 - P264 - P270 - P273 - P301 + P310 - P314
危险分类	Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT RE 1 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

358134

Fluorochem

4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one

>98.0%(HPLC)(T)

1166元/1g; 3872元/25g;

展开

基本信息

CAS Number	66-76-2
MDL Number	MFCD00006857
Melting Point	292℃

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H372: Causes damage to organs .. H411: Toxic to aquatic life with long lasting effects.
防范说明	P260: Do not breathe . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P273: Avoid release to the environment. P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P314: Get medical advice/attention if you feel unwell. P330: Rinse mouth. P391: Collect spillage. P501: Dispose of contents/container to local regulations.