CAS 65-49-6; 对氨基水杨酸; 4-Amino-2-hydroxbenzoic acid

CAS:

65-49-6

分子式:

C7H7NO3

分子量:

153.13

熔点:

147-148℃

中文名称:

对氨基水杨酸

4-氨基-2-羟基苯甲酸

3-氨基水杨酸

3-氨基-2-羟基苯甲酸

4-氨基柳酸

4-氨基水杨酸

对氨基邻羟基苯甲酸

英文名称:

4-Amino-2-hydroxbenzoic acid

Benzoic acid,4-amino-2-hydroxy-

4-Aminosalicylic acid

4-amino-2-hydroxy-Benzoic acid

4-amino-salicylic aci

2-hydroxy-4-aminobenzoic acid

3-hydroxy-4-carboxyaniline

4-amino-2-hydroxybenzoic acid

aminopar

aminosalicylic acid

aminox

apacil

apas

4-amino-2-hydroxy-benzoic aci

deapasil

entepas

gabbropas

helipidyl

hellipidyl

kyselina p-aminosalicylova

nsc 2083

osacyl

pamacyl

pamisyl

para-amino salicylic acid

para-aminosalicylic acid

para-pas

paramycin

parasal

parasalicil

parasalindon

pas

pas (acid)

pas [acid]

pas-c

pasa

pasalon

pasara

pascorbic

pasem

pask

pasmed

pasnodia

pasolac

propasa

rezipas

sanipirol-4

sanipriol-4

4-Aminosalicylic acid;4-Amino-2-hydroxybenzoic acid;PAS

4-aminosalicylic

4-aminosalicylicacid

展开更多英文名

性质描述:

该品为白色结晶。熔点为150-151℃（分解）。无臭或微有丙酮气味。溶于稀硝酸、稀氢氧化钠、丙酮、碳酸氢钠和磷酸，稍溶于乙醇，微溶于乙醚，不溶于水及苯。在40℃时该品水溶液不稳定，分解放出二氧化碳而生成氨基酚。暴露于空气中变为棕色。

生产方法:

由间氨基酚经羟化而得。将水、间氨基酚和碳酸氢钠依次投入反应罐内，通入二氧化碳置换空气后，密闭升温至110±1℃，罐内压力保持0.6-0.8MPa反应6h，冷却至-5℃，加亚硫酸钠，过滤，水洗，合并洗滤液供酸化用。滤饼为间氨基酚回收物，套用。将上述洗滤液升温至10-15℃，用30-40%硫酸中和至pH为6.4-7.0，加入适量的亚硫酸钠与硫化钠溶液，经树脂脱色后，于30℃用30-40%硫酸调节至pH为3- 3.5，放置，甩滤，水洗至硫酸根合格，甩干得对氨基水杨酸。从苯乙酸出发也可以合成得到对氨基水杨酸。先使苯乙酸在浓硫酸和浓硝酸中在60℃下硝化，然后倾入冰水中，过滤析出2,4-二硝基苯乙酸[643-43-6]。硝化产率95%。将得到的产物加入10倍甲醇中，均匀混合后，通入干燥的氯化氢，加热至沸，冷却后析出2,4-二硝基苯乙酸甲酯晶体[58605-12-2]。酯化产率为80%。将酯化物溶解于热甲醇中，加入亚硝酸丁酯，再加入甲醇钠，静置数小时直至完全析出深红色沉淀物，分离沉淀物得中间产物。将其溶于稀氢氧化钾溶液中，加入盐酸酸化，使呈酸性。逸出二氧化碳气体，析出4-硝基-2-羟基苯腈。产率为80%，将此腈化物与水、浓硫酸、冰醋酸混合加热至沸，即可析出4-硝基水杨酸[619-19-2]。将4-硝基水杨酸溶解于25%碳酸钠溶液中，加入硫酸亚铁水溶液，再加适量的碳酸钠溶液，加热至沸，分离析出铁盐。过滤，滤液用乙酸调至pH=3,4-氨基水杨酸则析出。再过滤干燥，即得产品。工业品对氨基水杨酸含量大于70%，氯化物小于50ppm，硫酸根小于500ppm。

用途:

医药中间体，用于合成抗结核病药对氨柳酸钠。也用于分析出试剂酸碱荧光指示剂。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

A797817

MACKLIN

对氨基水杨酸

10mM in DMSO

185元/1ml;

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储存：-20°C

A800397

MACKLIN

对氨基水杨酸

98%

29元/25g; 79元/100g; 335元/500g; 1448元/2.5kg;

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储存：室温
状态：白色到棕色粉末

A0420

TCI

4-Aminosalicylic Acid

>98.0%(T)

270元/25G; 980元/100G;

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基本信息

纯度/分析方法	>98.0%(T)
分子式/分子量	C₇H₇NO₃ = 153.14
外观与形状(20℃)	固体
储存在惰性气体下	存放于惰性气体之中
应避免的情况	光,空气
Reaxys-RN	473071
PubChem物质ID	87562054
SDBS (AIST Spectral DB)	1380
Merck Index (14)	477
MDL编号	MFCD00007789

技术规格

Appearance	White to Light gray to Light orange powder to crystal
Purity(HPLC)	min. 95.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Solubility in Methanol	almost transparency

物性(参考值)

熔点

151 ℃

安全信息

图形或危害标志
信号词	警告
危险性说明	H303 : 吞咽可能有害。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P312 : 如感觉不适，呼叫急救中心/医生。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

相关法规

RTECS#

VO1225000

171546

J&K

4-Aminosalicylic Acid

99%

464元/500G;

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基本信息

分子式	C₇H₇NO₃
分子量	153.14
熔点	135-145
MDL编码	MFCD00007789
Beilstein	473071
Merck	14,477
EINECS 编号	200-613-5

安全信息

图形或危害标志
提示语	Warning
危险说明	H319
防范说明	P305+P351+P338
WGK	2
RTECS	VO1225000
TSCA	是

B23289

Alfa Aesar

4-Aminosalicylic Acid

98+%

378元/100g; 2231元/500g;

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应用
Competitive pteridine synthetase inhibitor, has antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis. It inhibits NF-κB and folic acid synthesis.

备注
Store in cool, dry place in a well sealed container. Store away from oxidizing agents.

基本信息

MDL
MFCD00007789

EINECS
200-613-5

分子式
C₇H₇NO₃

分子量
153.14

熔点
ca 135-145° dec.

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water (2 g/L) at 20°C, dilute sodium hydroxide, dilute nitric acid, ether (slightly), methanol, acetone, and ethanol. Virtually insoluble in benzene, chloroform, and carbon tetrachloride.

Beilstein
473071

Merck
14,477

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

RTECS
VO1225000

TSCA
是

1026401

USP

Aminosalicylic acid

United States Pharmacopeia (USP) Reference Standard

2633.96元/125 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

线性分子式	H₂NC₆H₃-2-(OH)CO₂H
分子量	153.14
Beilstein	473071
MDL编号	MFCD00007789
PubChem化学物质编号	329748997
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
mp	135-145 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	Nc1ccc(C(O)=O)c(O)c1
InChI	1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)
InChI key	WUBBRNOQWQTFEX-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

A79604

Sigma-Aldrich

4-Aminosalicylic Acid

99%

163.18元/5 G; 311.2元/100 G;

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产品说明

应用

4-氨基水杨酸 (4-ASA) 可用于合成：

具有抗炎作用的 4-ASA 偶氮衍生物
用作药物成分的 4-氨基水杨酸铵晶型。
水杨酸-三唑类似物，用作铜绿假单胞菌的群体感应抑制剂。

包装

5, 100 g in glass bottle

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDF A79604.pdf 中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息，请访问sigma.com/metlin。

基本信息

线性分子式	H₂NC₆H₃-2-(OH)CO₂H
分子量	153.14
Beilstein	473071
EC 号	200-613-5
MDL编号	MFCD00007789
PubChem化学物质编号	24891299
NACRES	NA.22

产品性质

质量水平	200
测定	99%
形式	powder
reaction suitability	reaction type: solution phase peptide synthesis
颜色	white to beige
mp	135-145 ℃ (lit.)
application(s)	peptide synthesis
SMILES string	Nc1ccc(C(O)=O)c(O)c1
InChI	1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)
InChI key	WUBBRNOQWQTFEX-UHFFFAOYSA-N
Gene Information	human ... PTPN1(5770)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

V900740

Sigma-Aldrich

4-Aminosalicylic Acid

Vetec^™, reagent grade, 99%

154.45元/100 G;

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产品说明

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

线性分子式	H₂NC₆H₃-2-(OH)CO₂H
分子量	153.14
Beilstein	473071
EC 号	200-613-5
MDL编号	MFCD00007789
PubChem化学物质编号	329830112

产品性质

等级	reagent grade
产品线	Vetec^™
测定	99%
形式	powder
颜色	white to beige
mp	135-145 ℃ (lit.)
SMILES string	Nc1ccc(C(O)=O)c(O)c1
InChI	1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)
InChI key	WUBBRNOQWQTFEX-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

PHR1746

Supelco

4-Aminosalicylic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

1965.77元/500 MG;

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产品说明

一般描述

4-Aminosalicylic acid is an isomer of 5-ASA, the active component of sulfasalazine. This nonsteroidal anti-inflammatory drug (NSAID) has been used in the treatment of tuberculosis and is also known to be effective in treating distal ulcerative colitis.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA7969 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

线性分子式	H₂NC₆H₃-2-(OH)CO₂H
分子量	153.14
Beilstein	473071
EC 号	200-613-5
MDL编号	MFCD00007789
PubChem化学物质编号	329823591

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
包装	pkg of 500 mg
technique(s)	HPLC: suitable gas chromatography (GC): suitable
mp	135-145 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to USP 1026401
储存温度	2-30℃
SMILES string	Nc1ccc(C(O)=O)c(O)c1
InChI	1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)
InChI key	WUBBRNOQWQTFEX-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

078671

Fluorochem

4-Amino-2-hydroxybenzoic Acid

95%

220元/25g; 352元/100g; 1342元/500g;

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基本信息

CAS Number	65-49-6
MDL Number	MFCD00007789

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H332: Harmful if inhaled. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .