CAS 65-28-1; 甲磺酸酚妥拉明; Phentolamine methanesulfonate salt

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

P793469

MACKLIN

甲磺酸酚妥拉明

10mM in DMSO

331元/1ml;

展开

储存：-20°C

P817062

MACKLIN

甲磺酸酚妥拉明

≥98.0%(TLC)

119元/100mg; 419元/500mg; 639元/1g; 2099元/5g; 6399元/25g;

展开

储存：2~8°C
状态：白色到灰白色到粉色到浅黄色到浅橙色粉末到晶体

P1985

TCI

Phentolamine Mesylate

>98.0%(T)(HPLC)

520元/100MG; 1750元/1G;

展开

基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₁₇H₁₉N₃O・CH₄O₃S = 377.46
外观与形状(20℃)	固体
包装和容器	1G-带有塑料内管的玻璃瓶 (查看图片)
Reaxys-RN	3826682
PubChem物质ID	135727347
Merck Index (14)	7264
MDL编号	MFCD00134201

技术规格

Appearance	White to Light yellow to Light orange powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	178.0 to 182.0 ℃

物性(参考值)

熔点	180 ℃
水溶性	可溶
溶解性(可溶于)	乙醇
溶解度(极微溶)	氯仿

安全信息

图形或危害标志
信号词	警告
危险性说明	H302 + H312 + H332 : 吞咽、皮肤接触或吸入有害。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P261 : 避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾。 P270 : 使用本产品时不要进食、饮水或吸烟。 P271 : 只能在室外或通风良好之处使用。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。 P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。 P302 + P352 + P312 : 如皮肤沾染：用水充分清洗。如感觉不适，呼叫急救中心/医生。 P304 + P340 + P312 : 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。如感觉不适，呼叫急救中心/医生。

相关法规

RTECS#

SL5430000

300598

J&K

Phentolamine methanesulfonate salt

98%, 一种非选择性α-肾上腺素受体拮抗剂

982元/250MG; 2081元/1G;

展开

基本信息

分子式	C₁₈H₂₃N₃O₄S
分子量	377.46
熔点	180-182
MDL编码	MFCD00134201
Beilstein	3826682
EINECS 编号	200-604-6

产品描述

Phentolamine Mesylate是一种非选择性α-肾上腺素能拮抗剂，IC50为0.1 μM。

靶点（IC50 & Targe）

α-adrenergic receptor

体外研究

Phentolamine mesylate置换选择性α1受体拮抗剂[125I],[3H]prazosin和α2受体拮抗剂[3H]rauwolscine和[3H]RX 821002的结合，对海绵体膜相对高的亲和力。在肾上腺素受体激动剂phenylephrine，去甲肾上腺素，oxymetazoline，UK 14,304以及非肾上腺素收缩剂内皮素和氯化钾处理后预收缩的勃起组织带，Phentolamine mesylate引起浓度依赖性舒张。Phentolamine mesylate通过直接拮抗α1和2肾上腺素能受体以及通过非非肾上腺素，内皮介导的间接拮抗作用诱导海绵体勃起组织松弛，表明一氧化氮合酶活化。[1] Phentolamine，α-肾上腺素能拮抗剂，阻断在牙科麻醉药制剂中使用的和肾上腺素相关的血管收缩，从而增强从注射部位的局部麻醉剂的全身吸收。[2]

体内研究

Phentolamine是一个竞争性可逆α-肾上腺素受体拮抗剂，对α1和α2受体具有类似的亲和力。Phentolamine通过降低外周血管阻力导致血管扩张，从而低血压。[4] Phentolamine mesylate（30和100 nM）剂量依赖性地增强电场刺激诱导的兔子海绵体松弛。Phentolamine松驰兔阴茎海绵体，不依赖于α-肾上腺素能受体阻断。Phentolamine mesylate通过激活NO合酶松驰兔阴茎海绵体的非肾上腺素非胆碱能神经元，这是独立于α-肾上腺素能受体阻断的。[5]

参考文献

[1] Traish A, et al. Int J Impot Res,?998, 10(4), 215-223.

[2] Moore PA, et al. Anesth Prog,?008, 55(2), 40-48.

[3] Holt A, et al. J Pharm Pharmacol,?995, 47(10), 837-845.

[4] Vemulapalli S, et al. Fundam Clin Pharmacol,?001, 15(1), 1-7.

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H312 H332 H315 H319 H335
防范说明	P261 P280 P305+P351+P338
WGK	3
RTECS	SL5430000

PHR1403

Supelco

Phentolamine Mesylate

Pharmaceutical Secondary Standard; Certified Reference Material

1605.03元/1 G;

展开

产品说明

一般描述

Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Phentolamine Mesylate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chemiluminescence technique.

生化/生理作用

α-肾上腺素受体拮抗剂；外周血管舒张剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3261 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

线性分子式	C₁₇H₁₉N₃O · CH₃SO₃H
分子量	377.46
EC 号	200-604-6
MDL编号	MFCD00134201
PubChem化学物质编号	329823376
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable gas chromatography (GC): suitable
mp	180-182 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to PhEur Y0001127 traceable to USP 1530004
储存温度	2-30℃
SMILES string	CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI	1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChI key	OGIYDFVHFQEFKQ-UHFFFAOYSA-N
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0001127

Phentolamine mesilate

European Pharmacopoeia (EP) Reference Standard

1259.15元/ ;

展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

α-肾上腺素受体拮抗剂；外周血管舒张剂。

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

线性分子式	C₁₇H₁₉N₃O · CH₃SO₃H
分子量	377.46
MDL编号	MFCD00134201
PubChem化学物质编号	329831277
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
mp	180-182 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI	1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChI key	OGIYDFVHFQEFKQ-UHFFFAOYSA-N
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Y0001251

Phentolamine mesilate for system suitability

European Pharmacopoeia (EP) Reference Standard

1861.35元/ ;

展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

α-肾上腺素受体拮抗剂；外周血管舒张剂。

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

线性分子式	C₁₇H₁₉N₃O · CH₃SO₃H
分子量	377.46
MDL编号	MFCD00134201
PubChem化学物质编号	329831323
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
mp	180-182 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI	1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChI key	OGIYDFVHFQEFKQ-UHFFFAOYSA-N
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1530004

USP

Phentolamine Mesylate

United States Pharmacopeia (USP) Reference Standard

3231.47元/200 MG;

展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

α-肾上腺素受体拮抗剂；外周血管舒张剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

线性分子式	C₁₇H₁₉N₃O · CH₃SO₃H
分子量	377.46
MDL编号	MFCD00134201
PubChem化学物质编号	329750812
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
mp	180-182 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI	1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChI key	OGIYDFVHFQEFKQ-UHFFFAOYSA-N
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

P7561

Sigma-Aldrich

Phentolamine methanesulfonate salt

≥98% (TLC), powder

1445.1元/100 MG; 4186.71元/500 MG;

展开

产品说明

包装

100, 500 mg in poly bottle

生化/生理作用

α-肾上腺素受体拮抗剂；外周血管舒张剂。

特点和优势

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

线性分子式	C₁₇H₁₉N₃O · CH₃SO₃H
分子量	377.46
EC 号	200-604-6
MDL编号	MFCD00134201
PubChem化学物质编号	24277798
NACRES	NA.77

产品性质

质量水平	200
测定	≥98% (TLC)
形式	powder
颜色	white to off-white
mp	180-182 ℃ (lit.)
溶解性	ethanol: 26 mg/mL H₂O: 50 mg/mL
创始人	Novartis
SMILES string	CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI	1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChI key	OGIYDFVHFQEFKQ-UHFFFAOYSA-N
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

BP520

Phentolamine mesilate

British Pharmacopoeia (BP) Reference Standard

2135.03元/100 MG;

展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

α-肾上腺素受体拮抗剂；外周血管舒张剂。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

线性分子式	C₁₇H₁₉N₃O · CH₃SO₃H
分子量	377.46
EC 号	200-604-6
MDL编号	MFCD00134201
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
mp	180-182 ℃ (lit.)
格式	neat
储存温度	2-8℃
SMILES string	CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI	1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChI key	OGIYDFVHFQEFKQ-UHFFFAOYSA-N
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable