CAS 64520-05-4; 阿米替林代谢物，(±)-e-10-羟基化-

位置：首页 > 资料中心 > 化工字典 > 64520-05-4

CAS:

64520-05-4

中文名称:

阿米替林代谢物，(±)-e-10-羟基化-

amitriptyline metabolite, (±)-e-10-hydroxylated-

(±)-(e)-5-[3-(dimethylamino)propylidene]-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-10-ol

(±)-e-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5h-二苯并[a,d]环庚烯-10-醇

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

A115

Supelco

Amitriptyline metabolite, (±)-E-10-hydroxylated-

analytical standard

2772.04元/2 MG;

展开

产品说明

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

包装

2 mg in glass bottle

生化/生理作用

阿米替林代谢物，三环抗抑郁剂；色谱标准品。

基本信息

经验(实验)分子式	C₂₀H₂₃NO
分子量	293.40
MDL编号	MFCD00069200
PubChem化学物质编号	329770681
NACRES	NA.24

产品性质

质量水平	200
等级	analytical standard
形式	solid
technique(s)	HPLC: suitable gas chromatography (GC): suitable
颜色	white
mp	97-99 ℃
溶解性	0.1 M HCl: soluble H₂O: insoluble methanol: soluble
application(s)	forensics and toxicology pharmaceutical (small molecule)
格式	neat
SMILES string	CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13
InChI	1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+
InChI key	GHWBJXOKAFHZAI-SFQUDFHCSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

SMB00969

Sigma-Aldrich

(E)-10-Hydroxy amitriptyline

≥95% (HPLC)

6510.19元/10 MG;

展开

产品说明

一般描述

(E)-10-Hydroxy amitriptyline is a metabolite of Amitriptyline (brand name Elavil), a FDA-approved oral medicine for the treatment of major depressive and anxiety disorders, attention deficit hyperactivity disorder (ADHD), bipolar disorder, as well as migraines and neuropathic pain (fibromyalgia & postherpetic neuralgiapain). Amitriptyline acts mainly on the serotonin transporter (SERT) and moderately on the norepinephrine transporter (NET). Amitriptyline is metabolised by cytochrome P450 enzymes (demethylation by CYP2C19 & CYP3A4) in the liver to Nortriptyline, which also acts as a noradrenaline reuptake inhibitor and thereby potentiates the antidepressant effects of amitriptyline. Amitriptyline and Nortriptyline are subject to metabolisation by hydroxylation (by CYP2D6) and n-oxidation.

应用

Metabolomics research

生化/生理作用

阿米替林代谢物，三环抗抑郁剂；色谱标准品。

基本信息

经验(实验)分子式	C₂₀H₂₃NO
分子量	293.40
MDL编号	MFCD00069200

产品性质

质量水平	200
测定	≥95% (HPLC)
形式	solid
technique(s)	HPLC: suitable
颜色	white to yellow
储存温度	2-8℃
SMILES string	CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13
InChI	1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+
InChI key	GHWBJXOKAFHZAI-SFQUDFHCSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9