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CAS: 64-77-7
分子式: C12H18N2O3S
分子量: 270.35
中文名称: 
甲苯磺丁脲
甲磺丁脲
甲糖宁
英文名称: 
1-butyl-3-(p-tolylsulfonyl)-ure
1-butyl-3-(p-methylphenylsulfonyl)urea
1-butyl-3-(p-tolylsulfonyl)urea
1-butyl-3-tosylurea
1-p-toluenesulfonyl-3-butylurea
3-(p-tolyl-4-sulfonyl)-1-butylurea
aglicid
arcosal
arkozal
artosin
artozin
beglucin
n-((butylamino)carbonyl)-4-methyl-benzenesulfonamid
n-[(butylamino)carbonyl]-4-methyl-benzenesulfonamid
butamid
butamide
d 860
diaben
diabesan
diabetamid
diabetol
diabuton
dolipol
drabet
hls 831
ipoglicone
mobenol
n'-4-methylbenzenesulfonyl-n''-butylurea
n-(4-methylphenylsulfonyl)-n'-butylurea
n-(p-tolylsulfonyl)-n'-butylcarbamide
n-(p-tolylsulfonyl)n'-butylcarbamide
n-(sulfonyl-p-methylbenzene)-n'-butylurea
n-(sulfonyl-p-methylbenzene)-n'-n-butylurea
n-4-methylbenzolsulfonyl-n-butylurea
n-[(butylamino)carbonyl]-4-methylbenzenesulfonamide
n-butyl-n'-p-toluenesulfonylurea
n-butyl-n'-toluene-p-sulfonylurea
n-n-butyl-n'-tosylurea
nci-c01763
1-Butyl-3-(4-methylphenylsulfonyl)urea
orabet
1-n-Butyl-3-(p-tolylsulfonyl)urea
oralin
orezan
orinase
orinaz
oterben
pramidex
rastinon
sk-tolbutamide
tarasina
tolbet
tolbusal
tolbutamid
tolbutamide
tolbutamidum
tolbutone
toluina
tolumid
toluvan
tolylsulfonylbutylurea
u 2043
willbutamide
Tolbutol
1-Butyl-3-(para-tolysulfonyl)urea
benzenesulfonamide,N-[(butylamino)carbonyl]-4-methyl-
展开更多英文名
用途: 降血糖药,适用于稳定型的轻、中度的成年糖尿病患者。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
T792811MACKLIN甲苯磺丁脲10mM in DMSO431元/1ml;   展开
储存:-20°C
T836669MACKLIN甲苯磺丁脲≥99%30元/1g;   53元/5g;   218元/25g;   858元/100g;   展开
储存:2-8℃
状态:白色到灰白色粉末到晶体到结晶粉末
T3690TCITolbutamide>98.0%(T)(HPLC)300元/1G;   展开

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C12H18N2O3S = 270.35
外观与形状(20℃)固体
包装和容器 1G-带有塑料内管的玻璃瓶 (查看图片)
Reaxys-RN1984428
PubChem物质ID354335795
Merck Index (14)9507
MDL编号MFCD00027169

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Neutralization titration)min. 98.0 %
Melting point126.0 to 130.0 ℃

物性(参考值)

熔点127 ℃
最大吸收波长230 nm
水溶性不溶
在水中的溶解度109 mg/l   37 ℃
溶解性(可溶于)氯仿,乙醇

安全信息

信号词警告
危险性说明H303 : 吞咽可能有害。
防范说明P312 : 如感觉不适,呼叫急救中心/医生。

相关法规

RTECS#YS4550000
301955J&KTolbutamide97.5%535元/25G;   1764元/100G;   展开

基本信息

分子式C12H18N2O3S
分子量270.35
熔点128-130
MDL编码MFCD00027169
Beilstein1984428
Merck14,9507
EINECS 编号200-594-3

安全信息

防范说明P262
WGK2
RTECSYS4550000
TSCA
B21698Alfa AesarTolbutamide98%1031元/10g;   2300元/50g;   8226元/250g;   展开

应用
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

基本信息

MDL
MFCD00027169

EINECS
200-594-3

分子式
C12H18N2O3S

分子量
270.35

熔点
128-130°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in chloroform.

Beilstein
1984428

Merck
14,9507

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H317
Harmful if swallowed.May cause an allergic skin reaction.

Precautionary Statements
P261-P280g-P301+P312a-P321-P333+P313-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves.Wear protective gloves.Specific treatment (see label).If skin irritation or rash occurs: Get medical advice/attention.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
43
May cause sensitization by skin contact.

安全等级
24-37
Avoid contact with skin.

RTECS
YS4550000

TSCA

R12039Alfa AesarTolbutamide,1000ppm440元/1ml;   展开

安全信息

危险等级
3

T1700000TolbutamideEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

抗糖尿病制剂。由CYP2C9(甲苯磺丁脲羟化酶)所代谢。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C12H18N2O3S
分子量270.35
Beilstein1984428
MDL编号MFCD00027169
PubChem化学物质编号329826684
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InChI1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChI keyJLRGJRBPOGGCBT-UHFFFAOYSA-N
Gene Informationhuman ... ABCC8(6833), KCNJ11(3767)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
T0891SupelcoTolbutamideanalytical standard580.36元/25 G;   1495.02元/100 G;   展开

产品说明

应用

有关合适仪器技术的更多信息,请参考产品′s分析证书。如需进一步支持,请联系技术服务。

包装

25, 100, 500 g in glass bottle

生化/生理作用

抗糖尿病制剂。由CYP2C9(甲苯磺丁脲羟化酶)所代谢。

基本信息

经验(实验)分子式C12H18N2O3S
分子量270.35
Beilstein1984428
EC 号200-594-3
MDL编号MFCD00027169
PubChem化学物质编号329826629

产品性质

质量水平200
生物来源synthetic (organic)
等级analytical standard
测定97.0--103.0%
technique(s)HPLC: suitable
gas chromatography (GC): suitable
溶解性ethanol: 50 mg/mL, clear, colorless
application(s)forensics and toxicology
pharmaceutical (small molecule)
格式neat
SMILES stringCCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InChI1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChI keyJLRGJRBPOGGCBT-UHFFFAOYSA-N
Gene Informationhuman ... ABCC8(6833), ALB(213), CYP1A2(1544), CYP2C9(1559), EPHX2(2053), KCNJ1(3758), KCNJ11(3767)
mouse ... Ephx2(13850)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
1670003USPTolbutamideUnited States Pharmacopeia (USP) Reference Standard3036.37元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

抗糖尿病制剂。由CYP2C9(甲苯磺丁脲羟化酶)所代谢。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C12H18N2O3S
分子量270.35
Beilstein1984428
MDL编号MFCD00027169
PubChem化学物质编号329751342
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InChI1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChI keyJLRGJRBPOGGCBT-UHFFFAOYSA-N
Gene Informationhuman ... ABCC8(6833), KCNJ11(3767)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
047218FluorochemTolbutamide95%220元/5g;   484元/25g;   展开

基本信息

CAS Number64-77-7
MDL NumberMFCD00027169

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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