CAS 6384-92-5; n-methyl-d-aspartic aci

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产品名称

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N860138

MACKLIN

N-甲基-D-天门冬氨酸

≥97%

218元/250mg; 418元/1g; 1855元/5g;

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储存：室温,干燥
状态：白色到灰白色固体

N794359

MACKLIN

N-甲基-D-天门冬氨酸

100mmol/L in H2O

620元/1ml;

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储存：2-8°C

N794360

MACKLIN

N-甲基-D-天门冬氨酸

10mM in DMSO

1282元/1ml;

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储存：-20°C

M1360

TCI

N-Methyl-D-aspartic Acid

>98.0%(T)

190元/100MG;

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基本信息

纯度/分析方法	>98.0%(T)
分子式/分子量	C₅H₉NO₄ = 147.13
外观与形状(20℃)	固体
Reaxys-RN	1724431
PubChem物质ID	87573315
Merck Index (14)	6662
MDL编号	MFCD00004226

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 95.0 area%
Purity(Neutralization titration)	min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D	-14.0 to -17.0 deg(C=2, H2O)
Water	max. 5.0 %

物性(参考值)

熔点	178 ℃(dec.)
比旋光度 [α]D	-15° (C=2,H2O)

相关法规

RTECS#

CI9457000

421062

J&K

N-Methyl-D-aspartic Acid

98%, 是 NMDA receptor 的激动剂,能够模仿谷氨酸盐的活动

66元/50MG; 123元/250MG; 405元/1G;

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基本信息

分子式	C₅H₉NO₄
分子量	147.13
熔点	189-190
比旋光度([α]20D)	-30° to -26° (C=1, 6 N HCl)
MDL编码	MFCD00004226
Beilstein	1724431
Merck	14,6662

产品描述

NMDA (N-Methyl-D-aspartic acid)是一种特异性NMDA受体激动剂，通常作为受体，模拟神经递质谷氨酸的活性。Phase 4。

靶点（IC50 & Targe）

NMDA receptor

体外研究

NMDA是兴奋性氨基酸神经递质，只与NMDA受体结合，而不会影响其他谷氨酸受体（如AMPA和Kainate)。NMDA特异性与NMDA受体的NR2亚基结合，刺激非特异性阳离子通道的打开，使Ca2+和Na+ 进入细胞，K+输出细胞。NMDA受体的激活能够产生兴奋性突触后电位（EPSP），触发细胞内Ca2+含量的增加，这可能进一步参与多种不同的信号转导途径。NMDA受体对多种生理（如长时间增强作用和神经可塑性）和病理过程（如兴奋性毒性和癫痫）起着关键的作用。[1]

参考文献

[1] Cull-Candy S, et al. Curr Opin Neurobiol, 2001, 11(3), 327-335

安全信息

防范说明	P262
WGK	3
RTECS	CI9457000

C32919

Alfa Aesar

N-Methyl-D-aspartic Acid

98%

1932元/50mg; 10243元/250mg;

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基本信息

Ref#
32919

MDL
4226

分子式
C5 H9 N O4

分子量
147.1

454575

Sigma-Aldrich

N-Methyl-D-aspartic Acid, Hydrate-CAS 6384-92-5-Calbiochem

Excitatory amino acid neurotransmitter.

3815.77元/100 MG;

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产品说明

一般描述

Excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.
An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

包装

100 mg in Plastic ampoule

生化/生理作用

Primary Target
Glutamate receptor that regulates Ca2+ channels
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for several days at 4°C.

其他说明

Mattson, M.P., et al. 1993. J. Neurosci. 13, 4575.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₅H₉NO₄ · xH₂O
分子量	147.13 (anhydrous basis)
MDL编号	MFCD00004226

产品性质

质量水平	100
测定	>95% (TLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	water: 1 mg/mL
运输	ambient
储存温度	10-30℃
InChI	1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
InChI key	HOKKHZGPKSLGJE-GSVOUGTGSA-M

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

440506

Fluorochem

(R)-2-(Methylamino)succinic acid hydrochloride

95%

7106元/250mg; 15048元/1g;

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基本信息

CAS Number	6384-92-5
MDL Number	MFCD06795789

M03889

Fluorochem

(R)-2-(Methylamino)succinic acid

>98%

1100元/100mg; 2640元/1g;

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基本信息

CAS Number	6384-92-5
MDL Number	MFCD00004226
Melting Point	187-192℃

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.