CAS 63675-72-9; 尼索地平; 5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)- met

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货号

品牌

产品名称

规格

包装、参考价格

N858016

MACKLIN

尼索地平

99%

80元/1g; 240元/5g; 800元/25g;

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储存：室温,干燥
状态：淡到暗黄色固体

N794852

MACKLIN

尼索地平

10mM in DMSO

116元/1ml;

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储存：-20°C

N0900

TCI

Nisoldipine

>98.0%(HPLC)(N)

795元/1G; 1745元/5G;

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基本信息

纯度/分析方法	>98.0%(HPLC)(N)
分子式/分子量	C₂₀H₂₄N₂O₆ = 388.42
外观与形状(20℃)	固体
Reaxys-RN	454188
PubChem物质ID	160871273
Merck Index (14)	6565
MDL编号	MFCD00478055

技术规格

Appearance	Light yellow to Amber to Dark green powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 98.0 %
Melting point	148.0 to 154.0 ℃

物性(参考值)

熔点	153 ℃
水溶性	不溶
溶解性(易溶于)	二氯甲烷,丙酮
溶解性(可溶于)	甲醇

安全信息

图形或危害标志
信号词	警告
危险性说明	H302 + H312 + H332 : 吞咽、皮肤接触或吸入有害。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P261 : 避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾。 P270 : 使用本产品时不要进食、饮水或吸烟。 P271 : 只能在室外或通风良好之处使用。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/穿防护服。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。 P302 + P352 + P312 : 如皮肤沾染：用水充分清洗。如感觉不适，呼叫急救中心/医生。 P304 + P340 + P312 : 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。如感觉不适，呼叫急救中心/医生。

相关法规

RTECS#

US7975600

N0165

Sigma-Aldrich

Nisoldipine

≥98% (HPLC)

846.6元/10 MG; 3157.38元/50 MG;

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产品说明

应用

Nisoldipine has been used:

as a hit-antagonist to study its effects on oxytocin (OT)-induced myometrial Ca²⁺-mobilization and its potency to dampen uterine myometrial contractions
as a calcium channel blocker to study its effects on cell viability in a human hepatic cancer HepG2 and rat renal epithelial NRK52E cell line
as a component of the external IK1 recording solution to study the action potential in human pluripotent stem cell−derived cardiomyocytes (hiPS-CMs)

包装

10, 50 mg in glass bottle

生化/生理作用

L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.

特点和优势

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N0165.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

基本信息

经验(实验)分子式	C₂₀H₂₄N₂O₆
分子量	388.41
EC 号	264-407-7
MDL编号	MFCD00478055
PubChem化学物质编号	329818405
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	yellow
溶解性	DMSO: >10 mg/mL
创始人	Bayer
储存温度	room temp
SMILES string	COC(=O)C1=C(C)NC(C)=C(C1c2ccccc2[N+]([O-])=O)C(=O)OCC(C)C
InChI	1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
InChI key	VKQFCGNPDRICFG-UHFFFAOYSA-N
Gene Information	human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable