[登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 资料中心 > 化工字典 > 630-93-3
关键词:       仅模糊查询
CAS: 630-93-3
分子式: C15H11NaN2O2
分子量: 274.25
中文名称: 
苯妥英钠
大仑丁
5,5-二苯乙内酰脲钠
英文名称: 
5,5-diphenylhydantoin sodium salt
alepsin
aleviatin sodium
auranile
denyl sodium
derizene
di-len
dihydan
dilantin sodium
diphenin
diphenine
diphenine sodium
diphentoin
diphenylan sodium
diphenylhydantoin sodium
ditoin
enkefal
epanutin
epelin
epilan-d
epinat
eptoin
fenitoin sodium
hidantal sodium
hydantin
5,5-diphenyl-hydantoi sodium salt
hydantoinal
lepitoin sodium
novodiphenyl
om-hydantoine sodium
phenytoin sodium
sodium 5,5-diphenyl hydantoinate
sodium 5,5-diphenyl-2,4-imidazolidinedione
sodium 5,5-diphenylhydantoinate
sodium diphenyl hydantoinate
sodium diphenylhydantoin
sodium phenytoin
solantoin
solantyl
soluble phenytoin
tacosal
5,5-diphenylhydantoin sodium sigmaultra
5,5-Diphenyl-2,4-imidazo-lidinedione sodium
5,5-diphenyl-hydantoi monosodium salt
4-imidazolidinedione, 5,5-diphenyl- monosodium salt
5,5'-diphenylhydantoin
5,5-diphenylhydantoin sodium
展开更多英文名
性质描述: 白色粉末。易溶于水，溶于乙醇，几乎不溶于乙醚、氯仿。在空气中渐渐吸收二氧化碳而析出苯妥英。苯妥英熔点295-598℃，不溶于水，无臭，味苦。
生产方法: 苯甲醛经缩合、氧化得到联苯甲酰，然后与尿素重排、环合得到苯妥英钠。将水、尿素及联苯甲酰依次加入反应锅，搅拌加热至98℃，加入30%氢氧化钠，回流1.5h。加水及适量少性炭脱色，冷至26-28℃，过滤，滤液用5%左右盐酸酸化至pH=5-6，温度45-55℃，过滤，用水洗涤，得苯妥英。将苯妥英投入碱液中加热溶解，用氢氧化钠溶液调节pH至11-11.5，加活万籁 炭于75-80℃脱色半小时。压滤，冷至37-38℃，加入晶种放置结晶。冷至25℃过滤，结晶用蒸馏水洗涤，甩干，粉碎，于80℃左右干燥，得苯妥英钠。
用途: 抗癫痫药及抗心律失常药。对癫痫大发作疗效好，对精神运动性发作和局限性发作次之，对小发作不但无效，甚至能诱发。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
D807132MACKLIN苯妥英钠98%54元/25g;   148元/100g;   643元/500g;   2802元/2.5kg;   展开
储存：室温
状态：白色到浅黄色粉末
D792855MACKLIN苯妥英钠10mM in DMSO479元/1ml;   展开
储存：-20°C
D1331TCIPhenytoin Sodium>98.0%(T)390元/25G;   1435元/500G;   展开

基本信息

纯度/分析方法>98.0%(T)
分子式/分子量C15H11N2NaO2 = 274.25
外观与形状(20℃)固体
Reaxys-RN673467
PubChem物质ID87567851
Merck Index (14)7322
MDL编号MFCD00069674

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %
Purity(Ion exchange titration)min. 98.0 %

物性(参考值)

水溶性可溶
溶解性(可溶于)醇
溶解性(不溶于)氯仿,乙醚,苯

安全信息

图形或危害标志
信号词危险
危险性说明H302 : 吞咽有害。
H360 : 可能对生育能力或胎儿造成伤害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#MU1400000
365720J&KPhenytoin Sodium98%, 一种有效的多通道阻断剂232元/25G;   700元/100G;   展开

基本信息

分子式C15H11N2NaO2
分子量274.25
MDL编码MFCD00069674
Beilstein673467
Merck14,7322
EINECS 编号211-148-2
存储条件Freezer -20℃

产品描述

Phenytoin Sodium是一种失活的电压门控钠离子通道稳定剂。

靶点（IC50 & Targe）

Sodium Channel

安全信息

图形或危害标志
提示语Warning
危险说明H302
H317
H361
防范说明P280
UN号码2811
危险分类6.1
包装等级III
WGK3
RTECSMU1400000
C43610Alfa Aesar5,5-Diphenylhydantoin Sodium Salt99%672元/25g;   2309元/100g;   展开

基本信息

Ref#
43610

MDL
69674

分子式
C15 H11 N2 Na O2

分子量
274.25

PHR1492SupelcoPhenytoin SodiumPharmaceutical Secondary Standard; Certified Reference Material1392.96元/1 G;   展开

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Phenytoin sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

生化/生理作用

减少癫痫大发作的发生率；可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA3040 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

线性分子式C15H11N2O2Na
分子量274.25
EC 号211-148-2
MDL编号MFCD00069674
PubChem化学物质编号329823414

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 1 g
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to PhEur P1300000
traceable to USP 1535507
储存温度2-30℃
SMILES string[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
InChI keyFJPYVLNWWICYDW-UHFFFAOYSA-M
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07GHS08
警示用语：Warning
危险声明H302 - H317 - H361
预防措施声明P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
危险分类Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
P1300000Phenytoin SodiumEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

减少癫痫大发作的发生率；可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

包装

Unit quantity: 250 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

线性分子式C15H11N2O2Na
分子量274.25
MDL编号MFCD00069674
PubChem化学物质编号329820086
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
SMILES string[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
InChI keyFJPYVLNWWICYDW-UHFFFAOYSA-M
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07GHS08
警示用语：Warning
危险声明H302 - H317 - H361
预防措施声明P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
危险分类Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
D4505Sigma-Aldrich5,5-Diphenylhydantoin Sodium Salt≥99%787.89元/25 G;   1649.92元/100 G;   展开

产品说明

一般描述

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

应用

5,5-Diphenylhydantoin sodium salt has been used:

  • in the cream preparation for treating burn wounds
  • in seizure behavior testing as an anticonvulsant in Drosophila
  • in in vivo embryo toxicity test in mouse embryonic stem cells

生化/生理作用

减少癫痫大发作的发生率；可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

线性分子式C15H11N2O2Na
分子量274.25
EC 号211-148-2
MDL编号MFCD00069674
PubChem化学物质编号24277707
NACRESNA.77

产品性质

质量水平200
测定≥99%
溶解性aqueous base: soluble
SMILES string[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
InChI keyFJPYVLNWWICYDW-UHFFFAOYSA-M
Gene Informationhuman ... CNR1(1268), CNR2(1269), CYP2C9(1559), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Faah(29347), Scn1a(81574), Scnn1g(24768), Slc6a1(79212)

安全信息

象形图GHS07GHS08
警示用语：Warning
危险声明H302 - H317 - H361
预防措施声明P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
危险分类Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
1535507USPPhenytoin SodiumUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   展开

产品说明

一般描述

Phenytoin sodium is an anti-epileptic drug, which belongs to the hydantoin family.

生化/生理作用

减少癫痫大发作的发生率；可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

线性分子式C15H11N2O2Na
分子量274.25
MDL编号MFCD00069674
PubChem化学物质编号329750830
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES string[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
InChI keyFJPYVLNWWICYDW-UHFFFAOYSA-M
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07GHS08
警示用语：Warning
危险声明H302 - H317 - H361
预防措施声明P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
危险分类Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9