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CAS: 63-92-3
分子式: C18H22ClNO·HCl
分子量: 349.34
熔点: 139°C
中文名称: 
苯苄胺
苯氧苄胺
酚苄胺
英文名称: 
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzylamin hydrochloride
2-(n-benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride
bensylyt nen
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzenemethanamin hydrochlo
benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)amine hydrochloride
dibenzyline hydrochloride
dibenzyran
fenossibenzamina
fenoxybenzamin
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)benzylamine, hydrochloride
n-2-phenoxyisopropyl-n-benzyl-chloroethylamine hydrochloride
n-benzyl-n-phenoxyisopropyl-beta-chlorethylamine hydrochloride
n-phenoxyisopropyl-n-benzyl-beta-chloroethylamine hydrochloride
nci-c01661
phenoxybenzamide hydrochloride
phenoxybenzamine hydrochloride
skf 688a
展开更多英文名
性质描述: 白色结晶性粉末。熔点137.5-140℃。溶于乙醇、氯仿、丙二醇,略溶于苯,微溶于冷水。其游离碱熔点38-40℃,溶于苯。
用途: α-受体阴断剂,选择性强,作用持久。主要用于嗜铬细胞瘤、雷诺氏综合症、物足发绀及冻疮后遗症。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
P798100MACKLINPhenoxybenzamine HCl10mM in DMSO125元/1ml;   展开
储存:-20°C
状态:液体
P864422MACKLINPhenoxybenzamine HCl98%245元/1g;   1021元/5g;   3002元/25g;   展开
储存:室温
状态:白色到几乎白色粉末到晶体
D0158TCIPhenoxybenzamine Hydrochloride>98.0%(T)270元/1G;   3300元/25G;   展开

基本信息

纯度/分析方法>98.0%(T)
分子式/分子量C18H22ClNO・HCl = 340.29
外观与形状(20℃)固体
Reaxys-RN3747029
PubChem物质ID87566885
Merck Index (14)7256
MDL编号MFCD00055152

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(Nonaqueous Titration)min. 98.0 %
Melting point135.0 to 140.0 ℃

物性(参考值)

熔点139 ℃
溶解性(可溶于)甲醇

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H351 : 怀疑致癌。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#DP3750000
192714J&KPhenoxybenzamine Hydrochloride98%, 一种具有选择性的α-肾上腺受体和钙调蛋白抑制剂, 是一种常用的抗高血压药523元/1G;   1205元/5G;   展开

基本信息

分子式C18H22ClNO·HCl
分子量340.29
MDL编码MFCD00055152
Beilstein3747029
存储条件Freezer -20℃

产品描述

Phenoxybenzamine HCl是一种非选择性,不可逆α受体拮抗剂,IC50为550 nM。

靶点(IC50 & Targe)

CAM

α-adrenergic receptor,550nM

安全信息

图形或危害标志
危险说明H302
H410
防范说明P264
P270
P273
P301+P312
P330
P391
P501
UN号码3077
危险分类9
包装等级III
RTECSDP3750000
B019Sigma-AldrichPhenoxybenzamine Hydrochloride≥97%, powder1485.01元/250 MG;   展开

产品说明

包装

250 mg in glass bottle

生化/生理作用

钙调蛋白拮抗剂;α-肾上腺素受体拮抗剂。

特点和优势

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
该化合物由Wellspring开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处。

基本信息

经验(实验)分子式C18H22ClNO · HCl
分子量340.29
EC 号200-569-7
MDL编号MFCD00055152
PubChem化学物质编号24277760

产品性质

质量水平100
测定≥97%
形式powder
颜色 white
溶解性H2O: slightly soluble
alcohol: soluble
propylene glycol: soluble
创始人Wellspring
储存温度2-8℃
SMILES stringCl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2
InChI1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H
InChI keyVBCPVIWPDJVHAN-UHFFFAOYSA-N
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H302 - H351
预防措施声明P201 - P301 + P312 + P330 - P308 + P313
危险分类Acute Tox. 4 Oral - Carc. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
PHR1402SupelcoPhenoxybenzamine HydrochloridePharmaceutical Secondary Standard; Certified Reference Material839.6元/1 G;   展开

产品说明

一般描述

Phenoxybenzamine Hydrochloride is an important drug belonging to the class of β-chloroethylamine drugs. It functions as an α-blocker by binding to α-adrenoreceptors, located on vascular smooth muscles and stops the influence of sympathetic nerves on blood vessels. It is widely used in the treatment of hypertension, benign prostatic hyperplasia and hypoplastic left heart syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Phenoxybenzamine Hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and chemiluminescence techniques.

生化/生理作用

钙调蛋白拮抗剂;α-肾上腺素受体拮抗剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA2196 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C18H22ClNO · HCl
分子量340.29
EC 号200-569-7
MDL编号MFCD00055152
PubChem化学物质编号329823375
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to USP 1526007
储存温度2-30℃
SMILES stringCl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2
InChI1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H
InChI keyVBCPVIWPDJVHAN-UHFFFAOYSA-N
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H302 - H351
预防措施声明P201 - P301 + P312 + P330 - P308 + P313
危险分类Acute Tox. 4 Oral - Carc. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP1072Phenoxybenzamine HydrochlorideBritish Pharmacopoeia (BP) Reference Standard2144.18元/100 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

钙调蛋白拮抗剂;α-肾上腺素受体拮抗剂。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C18H22ClNO · HCl
分子量340.29
MDL编号MFCD00055152
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringCl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2
InChI1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H
InChI keyVBCPVIWPDJVHAN-UHFFFAOYSA-N
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H302 - H351
预防措施声明P201 - P202 - P264 - P280 - P308 + P313 - P501
危险分类Acute Tox. 4 Oral - Carc. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1526007USPPhenoxybenzamine HydrochlorideUnited States Pharmacopeia (USP) Reference Standard3231.47元/250 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

钙调蛋白拮抗剂;α-肾上腺素受体拮抗剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C18H22ClNO · HCl
分子量340.29
MDL编号MFCD00055152
PubChem化学物质编号329750803

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度15-25℃
SMILES stringCl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2
InChI1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H
InChI keyVBCPVIWPDJVHAN-UHFFFAOYSA-N
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H302 - H351
预防措施声明P280 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Carc. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
M02323FluorochemPhenoxybenzamine.HCl>99%792元/1g;   6952元/25g;   展开

基本信息

CAS Number63-92-3
MDL NumberMFCD00055152
Melting Point139℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H351: Suspected of causing cancer ..
防范说明 P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P281: Use personal protective equipment as required.
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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