CAS 62-68-0; beta-diethylaminoethyl diphenylpropylacetate hydrochloride

CAS:

62-68-0

分子式:

C23H31NO2.HCl

分子量:

389.96

熔点:

122 - 123 °C

英文名称:

beta-diethylaminoethyl diphenylpropylacetate hydrochloride

diethylaminoethanol ester of diphenylpropylacetic acid hydrochloride

nsc 39690

pentanoic acid, 2,2-diphenyl-, 2-(n,n-diethylamino)ethyl ester, hydrochloride

proadifen hydrochloride

propyladiphenin

skf 525a

u 5446

α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester

valeric acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester, hydrochloride

2'-diethylaminoethyl 2,2-diphenylpentanoate hydrochloride

2-diethylaminoethyl 2,2-diphenylvalerate hydrochloride

2-diethylaminoethyl alpha,alpha-diphenyl valerate hydrochloride

5171 rp

alpha-phenyl-alpha-propyl-benzeneacetic aci 2-(diethylamino)ethyl ester h

展开更多英文名

用途:

SKF-525A HCl (Proadifen) has many biochemical functions, some of which include: inhibitory effects on NOS1 (neuronal nitric oxide synthase; IC50 = 90 mM), adult mouse skeletal muscle AChR (acetyl choline receptor), hepatic drug metabolism via the CYP (cytochrome P450) system, CYP-dependent (cytochrome P450-dependent) arachidonate metabolism (90% at 50 μM), transmembrane calcium influx, and platelet thromboxane synthesis. This compound has also been shown to block KIR6.1 (ATP-sensitive inward rectifier potassium channel 8; IC50 = 4.4 mM) and stimulate endothelial cell prostacyclin production.

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货号

品牌

产品名称

规格

包装、参考价格

S797769

MACKLIN

普罗地芬盐酸盐

10mM in DMSO

620元/1ml;

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储存：-20°C
状态：液体

S863799

MACKLIN

普罗地芬盐酸盐

95%

520元/250mg; 1198元/1g;

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储存：-20°C
状态：白色到黄色粉末

126379

J&K

Proadifen hydrochloride

95%

2391元/2G; 7651元/10G;

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基本信息

分子式	C₂₃H₃₁NO₂·HCl
分子量	389.96
熔点	122-123
MDL编码	MFCD00055151
存储条件	Freezer -20℃

安全信息

防范说明	P262
WGK	3
RTECS	YV7175000

567300

Sigma-Aldrich

SKF-525A, Hydrochloride-CAS 62-68-0-Calbiochem

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.

5307.21元/1 G;

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产品说明

一般描述

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels. Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Stimulates endothelial cell prostacyclin production while inhibiting platelet thromboxane synthesis. Potentiates the action of many drugs in vivo.
Cell permeable. Blocks glibenclamide-sensitive K⁺ channels (IC₅₀ = 4.4 µM). Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P-450 system. Stimulates endothelial cell prostocyclin production while inhibiting platelet thromboxane synthesis. Potentiates the effect of many drugs in vivo.

包装

1 g in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
nNOS
Target IC₅₀: 90 µM against neuronal nitric oxide synthase

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

其他说明

Hecker, M., et al. 1994. J. Neurochem. 62, 1524.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol.252, 117.
Khan, S., et al. 1993. Biochem. Pharmacol.45, 439.
Boeynaems, J.M., et al. 1986. Prostaglandins32, 145.
Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther.198, 347.
Grasdalen, J., et al. 1975. FEBS Lett.60, 240.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₃H₃₁NO₂ · xHCl
分子量	353.50 (free base basis)
MDL编号	MFCD00055151

产品性质

质量水平	100
测定	≥98% (TLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	water: 20 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H
InChI key	FHIKZROVIDCMJA-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

P1061

Supelco

Proadifen hydrochloride

analytical standard, ≥95%

1522.17元/100 MG; 5513.73元/500 MG;

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产品说明

应用

盐酸普瑞迪芬可用作内标，用气相色谱-质谱联用(GC-MS)测定人尿样中的 O-去甲基曲马多、曲马多和 N-去甲基曲马多镇痛剂。
有关合适的仪器技术的更多信息，请参阅产品的分析证书。如需进一步支持，请联系技术服务。

包装

100, 500 mg in poly bottle

生化/生理作用

阻断格列本脲敏感 K⁺ 通道。抑制神经元性一氧化氮合成酶和细胞色素 P450

基本信息

经验(实验)分子式	C₂₃H₃₁NO₂ · HCl
分子量	389.96
MDL编号	MFCD00055151
PubChem化学物质编号	329820069
NACRES	NA.24

产品性质

质量水平	200
等级	analytical standard
测定	≥95%
technique(s)	HPLC: suitable gas chromatography (GC): suitable
mp	122-123 ℃
application(s)	forensics and toxicology pharmaceutical (small molecule)
格式	neat
储存温度	−20℃
SMILES string	Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2
InChI	1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H
InChI key	FHIKZROVIDCMJA-UHFFFAOYSA-N
Gene Information	human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

462723

Fluorochem

Proadifen hydrochloride

95%

1342元/250mg; 3322元/1g;

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基本信息

CAS Number	62-68-0
MDL Number	MFCD00055151