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CAS: 61-75-6
分子式: C18H24BrNO3S
分子量: 414.37
熔点: 97-99°C
中文名称: 
溴苄乙胺
溴苄铵托西酸盐
N-乙基-N-邻溴苄基-N,N-二甲基-对甲苯磺酸铵
溴苄铵
特兰新
英文名称: 
Bretylium tosilate
Brety-late
(o-bromobenzyl)ethyldimethyl-ammoniu p-toluenesulfonate
(o-bromobenzyl)ethyldimethylammonium p-toluenesulfonate
2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium 4-methylbenzenesulfonate
asl-603
2-bromo-n-ethyl-n,n-dimethyl-benzenemethanaminiu salt with 4-methylbenzen
esulfonic acid
2-bromo-n-ethyl-n,n-dimethyl-benzenemethanaminiu salt with 4-methylbenzenes
ulfonic acid (1:1)
bretylan
bretylate
bretylium p-toluenesulfonate
bretylium tosylate
bretylol
darenthin
darentin
dimethylethyl-o-bromobenzylammonium-p-toluenesulphonate
n-ethyl-n-o-bromobenzyl-n,n-dimethylammonium tosylate
ornid
展开更多英文名
性质描述: 白色结晶性粉末。熔点97-99℃。极易溶于水、醇、丙酮,不溶于苯、醚、乙酸乙酯、己烷。
生产方法: 以邻甲苯胺为原料,经重氮化脱氮并用溴置换生成邻溴甲苯,在光照下和溴素溴化生成邻溴苄基溴甲烷,再用二甲胺在压力下胺化得邻溴苄基二甲胺,最后与对-甲基磺酸乙酯加成得成品。
用途: 该品为一种肾上腺素阻滞剂。以提高心室致颤阈,故可防治心室颤动,并能直接加强心肌收缩力,改善房室传导作用,用于各种病因所致的室性心律失常,如频发性早搏、阵发性室性心动过速、心室扑动和颤动,尤其对锑剂所致阿-斯氏综合症效果较好。此外,对由于电解质紊乱、酸碱失去平衡或由于洋地黄、奎尼丁等药物中毒所引起的心律失常,也有一定的疗效。为抗心律失常的较好药物。该品有毒。小鼠口服LD50400mg/kg;大鼠肌内注射LD50为250mg/kg。对
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货号品牌产品名称规格包装、参考价格详情
B849139MACKLIN托西溴苄铵98%303元/5mg;   516元/10mg;   1234元/50mg;   3069元/250mg;   展开
储存:室温,干燥
1076352USPBretylium tosylateUnited States Pharmacopeia (USP) Reference Standard3572.92元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade; class III antiarrhythmic agent; competitive inhibitor of acetylcholinesterase.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C18H24BrNO3S
分子量414.36
MDL编号MFCD00038731
PubChem化学物质编号329749129
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCc1ccc(cc1)S([O-])(=O)=O.CC[N+](C)(C)Cc2ccccc2Br
InChI1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
InChI keyKVWNWTZZBKCOPM-UHFFFAOYSA-M
Gene Informationhuman ... SLC6A2(6530)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 + H312 + H332
预防措施声明P261 - P280 - P301 + P312 + P330
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
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