CAS 60607-34-3; 奥沙米特; 1-[-3-[4-(Diphenylmethyl)-1-piperazainyl]propyl]-2-binzimidazolone

CAS:

60607-34-3

分子式:

C27H30N4O

分子量:

426.57

中文名称:

奥沙米特

1-[-3-[4-(二苯基甲基)-1-哌嗪基]丙基]-2-苯并咪唑酮

英文名称:

1-[-3-[4-(Diphenylmethyl)-1-piperazainyl]propyl]-2-binzimidazolone

2h-benzimidazol-2-one, 1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propy

1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2h-benzimidaz ol-2

1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone

kw-4354

oxatimide

oxatomida

oxatomide

r 35443

tinset

1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2h-benzimidazol-2-on

展开更多英文名

性质描述:

白色粉末。熔点153.6℃。

生产方法:

将5.3份1-（3-氯丙基）-2H-苯并咪唑-2-酮，5份1-（二苯甲基）哌嗪，6.4份碳酸氢钠和200份4-甲基-2-戊酮，一起搅拌回流过夜，反应生成奥沙米特，经分离提纯而得成品。

用途:

抗组胺药，平喘药。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

O936817

MACKLIN

欧诗美锭

99%

468元/1mg;

咨询

储存：-20°C，干燥，密封
状态：白色到灰白色粉末

O9387

Sigma-Aldrich

Oxatomide

≥99%

3053.28元/10 MG;

咨询

产品说明

一般描述

Oxatomide, a histamine H1-receptor antagonist, is bound at high levels to plasma proteins in human blood.

生化/生理作用

Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines. Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma and vulvar lichen sclerosus.
Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₂₇H₃₀N₄O
分子量	426.55
EC 号	262-320-9
MDL编号	MFCD00211147
PubChem化学物质编号	24278615
NACRES	NA.77

产品性质

质量水平	100
测定	≥99%
颜色	white
溶解性	DMSO: soluble ethanol: soluble
创始人	Johnson & Johnson
SMILES string	O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5
InChI	1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
InChI key	BAINIUMDFURPJM-UHFFFAOYSA-N
Gene Information	human ... DRD3(1814)

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves