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CAS: 60-80-0
分子式: C11H12N2O
分子量: 188.23
沸点: 319℃
熔点: 109-113℃
中文名称: 
安替比啉
安替比林
安替吡啉
1,5-二甲基-2-苯基-3-吡唑啉酮
非那宗
二甲基苯基吡唑酮
英文名称: 
1,5-Dimethyl1-2-phenyl-3-pyrazolone
Phena-zone
1-Pheny-1-2,3-dimethylpyrazolone-[5],1,2-Di-hydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
3-Dimethyl-1-p
1,5-Dimethyl-2-phenyl-3-pyrazolone
1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-one
1-phenyl-2,3-dimethyl-5-pyrazolone
1-phenyl-2,3-dimethylpyrazole-5-one
2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
2,3-dimethyl-1-phenyl-5-pyrazolone
1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on
analgesine
anodynin
anodynine
antipirin
antipyrin
antipyrine
apirelina
azophen
azophene
dimethyloxychinizin
dimethyloxyquinazine
fenazon
fenazone
methozin
oxydimethylquinazine
parodyne
phenazone (pharmaceutical)
phenazonum
phenozone
phenylon
phenylone
pyrazophyl
sedatin
sedatine
1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one
展开更多英文名
性质描述: 该品为无色晶体或白色结晶性粉末。熔点114℃，沸点319℃（98.8kPa），211-212℃（1.33kPa），相对密度1.0747(20/4℃)，折光率1.5697。溶于苯、乙醇、水、氯仿，略溶于醚。无臭，有微苦味。
生产方法: 由1-苯基-3-甲基吡唑酮-5经甲基化、水解而得。在干燥的甲基化罐中，加入吡唑酮，再加入硫酸二甲酯，升温至160℃，反应6h，加热水煮沸2h。将此甲基化反应物放入盛有氢氧化钠溶液的水解罐中，在100-110℃搅拌水解3h。静置分层，取安替比林油层放在结晶罐内，加蒸馏水稀释，搅拌，降温至10℃以下，析出晶体，甩滤，水洗，甩干得安替比林粗品。粗品用蒸馏水重结晶，活性炭脱色，即得成品。甲基化操作还可以采用氯甲烷或溴甲烷作原料，将这类甲基化试剂作成甲醇溶液，稍微过量地与1-萘基-3-甲基吡啶酮搅拌反应。然后蒸去甲醇，将反应物溶于水中，用氢氧化钠使呈微碱性，用苯萃取安替比林，再从苯中重结晶，最后用活性炭精制和水重晶。另一种方法是，用等摩尔的N，N-苯基甲基肼和乙酰乙酸乙酯在130-160℃油浴上加热回流制得。用沸水从浓稠的油状液体中萃取安替比林，然后蒸发除去水而得到晶体。
用途: 该品为解热镇痛药，这类非甾抗炎药具有较强的解热镇痛、抗炎及抗风湿作用。但由于不良反应严重，临床应用已日趋减少，其中的一些老品种已逐渐趋向淘汰。安替比林、氨基比林、安乃近等片剂都是卫生部1982年9月公布的淘汰药品。安替比林是一种分析试剂。用于硝酸、亚硝酸及碘的分析，用于测定形成络合阳离子的元素，重量分析测定钛。
推荐供应商
货号品牌产品名称规格包装、参考价格
A800873MACKLIN安替比林99%61元/100g;   185元/500g;   888元/2.5kg;   咨询
储存：2~8°C
状态：白色晶体粉末
A796175MACKLIN安替比林10mM in DMSO350元/1ml;   咨询
储存：-20°C
状态：液体
D1876TCIAntipyrine>99.0%(GC)(T)255元/25G;   1090元/500G;   咨询

基本信息

纯度/分析方法>99.0%(GC)(T)
分子式/分子量C11H12N2O = 188.23
外观与形状(20℃)固体
Reaxys-RN157775
PubChem物质ID87568340
SDBS (AIST Spectral DB)22106
Merck Index (14)716
MDL编号MFCD00003146

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(GC)min. 99.0 %
Purity(Nonaqueous Titration)min. 99.0 %
Melting point109.0 to 113.0 ℃
Solubility in Wateralmost transparency

物性(参考值)

熔点113 ℃
沸点319 ℃
水溶性完全溶解
溶解性(易溶于)乙醇,氯仿
溶解性(微溶于)乙醚

安全信息

图形或危害标志
信号词危险
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H370 : 会损害器官。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P260 : 不要吸入粉尘/ 烟/ 气体/ 烟雾/ 蒸气/ 喷雾。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P308+P311 : 如接触到或有疑虑：呼叫急救中心/医生。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#CD2450000
A11089Alfa AesarAntipyrine98%513元/100g;   1886元/500g;   咨询

基本信息

MDL
MFCD00003146

EINECS
200-486-6

分子式
C11H12N2O

分子量
188.23

熔点
111-114°

形态
Crystalline powder

Beilstein
157775

Merck
14,716

GHS危害和防范说明

GHS符号

Hazard Statements
H302
Harmful if swallowed.

Precautionary Statements
P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Do not eat, drink or smoke when using this product.Rinse mouth.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22
Harmful if swallowed.

安全等级
36-60
Wear suitable protective clothing.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
CD2450000

TSCA
是

C10497Alfa AesarAntipyrine99%631元/100g;   1702元/500g;   咨询

基本信息

Ref#
10497

MDL
3146

分子式
C11 H12 N2 O

分子量
188.23

形态
Crystalline

P0800000PhenazoneEuropean Pharmacopoeia (EP) Reference Standard1572.16元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C11H12N2O
分子量188.23
Beilstein157775
MDL编号MFCD00003146
PubChem化学物质编号329820058
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp109-111 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCN1N(C(=O)C=C1C)c2ccccc2
InChI1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
InChI keyVEQOALNAAJBPNY-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 1
A5882SupelcoAntipyrineanalytical standard206.12元/25 G;   623.69元/100 G;   1880.09元/500 G;   咨询

产品说明

一般描述

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

应用

安替比林可用作：

  • 各种色谱技术测定动物血浆和血清中 分析物的药物参考标准品。
  • 胶束电动色谱法分析人血浆中肌酐和尿酸的内标物。
  • 由于其理化、生化和药代动力学特性，用于研究疾病、药物和环境因素对人和动物体内肝氧化代谢活性影响的参考标准品。

有关合适的仪器技术的更多信息，请参阅产品的分析证书。想要获得更多支持，请联系技术服务部。

包装

25, 100, 500 g in poly bottle

基本信息

经验(实验)分子式C11H12N2O
分子量188.23
Beilstein157775
EC 号200-486-6
MDL编号MFCD00003146
PubChem化学物质编号24891029

产品性质

等级analytical standard
质量水平100
保质期limited shelf life, expiry date on the label
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp109-111 ℃ (lit.)
application(s)forensics and toxicology
pharmaceutical (small molecule)
格式neat
SMILES stringCN1N(C(=O)C=C1C)c2ccccc2
InChI1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
InChI keyVEQOALNAAJBPNY-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 1
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
1040005USPAntipyrineUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C11H12N2O
分子量188.23
Beilstein157775
MDL编号MFCD00003146
PubChem化学物质编号329749046
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp109-111 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCN1N(C(=O)C=C1C)c2ccccc2
InChI1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
InChI keyVEQOALNAAJBPNY-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 1
V900710SupelcoAntipyrineVetec™, reagent grade, 98%142.17元/100 G;   437.51元/500 G;   咨询

产品说明

包装

100, 500 g in poly bottle

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

经验(实验)分子式C11H12N2O
分子量188.23
Beilstein157775
EC 号200-486-6
MDL编号MFCD00003146
PubChem化学物质编号329830082

产品性质

等级reagent grade
产品线Vetec™
测定98%
mp109-111 ℃ (lit.)
SMILES stringCN1N(C(=O)C=C1C)c2ccccc2
InChI1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
InChI keyVEQOALNAAJBPNY-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 1
358184Fluorochem1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one>99.0%(GC)(T)220元/25g;   638元/100g;   咨询

基本信息

CAS Number60-80-0
MDL NumberMFCD00003146
Melting Point109-114℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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