CAS 59-66-5; 2-乙酰氨基-1,3,4-噻二唑-5-磺酰胺; acetazolamide

CAS:

59-66-5

分子式:

C4H6N4O3S2

分子量:

222.25

中文名称:

2-乙酰氨基-1,3,4-噻二唑-5-磺酰胺

醋唑磺胺

醋氮酰胺

乙酰唑胺

英文名称:

acetazolamide

acetazoleamide

acetozalamide

carbonic anhydrase inhibitor no 6063

carbonic anhydrase inhibitor no. 6063

cidamex

defiltran

dehydratin

diacarb

diakarb

diamox

didoc

diluran

diuramid

diureticum-holzinger

diuriwas

diutazol

donmox

duiramid

edemox

eumicton

fonurit

glaupax

glupax

n-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide

n-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

natrionex

nephramid

nephramide

phonurit

vetamox

2-Acetamino-1,3,4-thiadiazol-5-sulfonamide

n-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-acetamid

4-thiadiazole-2-sulfonamide, 5-acetamido-3

2-acetamido-5-sulfonamido-1,3,4-thiadiazole

2-acetylamino-1,3,4-thiadiazole-5-sulfonamide

4-diamox

5-acetamide-1,3,4-thiadiazole-2-sulfonamide

6063

n-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-acetamid

n-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-acetamid

acetamidothiadiazolesulfonamide

acetamox

acetazolamid

展开更多英文名

性质描述:

白色针状结晶或结晶性粉末。熔点256-261℃（分解）。无臭，味微苦。略溶于沸水，微溶于水，乙醇，几乎不溶于氯仿或乙醚，易溶于氨溶液。

生产方法:

1.氯化、氧化2-乙酰氨基-5-巯基-1,3,4-噻二唑加入冰醋酸及水混合液中，冷却至-2℃通氯，终温不超过5℃。当物料温度显著下降，液面有大量泡沫出现，液氯耗用至规定量时停止通氯，过滤，滤饼用冰水洗涤至pH为4，得氯氧化物（2-乙酰氯基-5-磺酰氯-1,3,4-噻二唑）。2.胺化将氨水与碎冰混合，降温至5℃以下。加入氯氧化物，加毕，保温反应半小时。用盐酸调节pH至5-6，过滤，滤饼洗涤至pH为7，干燥，得乙酰唑胺粗品。将粗品、水、活性炭及偏重亚硫酸钠加热至95℃，脱色1-1.5h，趁热过滤，滤液冷却结晶，过滤，洗涤，干燥，得乙酰唑胺。

用途:

该品为利尿药。为碳酸酐酶抑制剂，服后抑制肾小管上皮细胞中的碳酸酐酶，使H2CO3的形成减少，H+的产生随之下降。因此，H+与Na+的交换大为减慢，结果HCO3-，Na+，K+排出增加，尿量增多。该品尚能抑制房水分泌过程，使眼压下降。用于治疗青光眼，轻度心脏性水肿等。

推荐供应商

货号	品牌	产品名称	规格	包装、参考价格	详情
L07562	Alfa Aesar	Acetazolamide	99%	314元/5g; 1043元/25g;	展开
应用 Acetazolamide acts as a carbonic anhydrase inhibitor which increases cerebral blood flow. It inhibits water permeability of membranes by interacting with aquaporins. It is used for the medical treatment of glaucoma, epileptic seizure, idiopathic intracranial hypertension, altitude sickness, cystinuria. 备注 Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents. Incompatible materials are oxidizing agents, bases. 基本信息 MDL MFCD00003105 EINECS 200-440-5 分子式 C₄H₆N₄O₃S₂ 分子量 222.25 熔点 ca 255° dec. 灵敏度 Ambient temperatures. 溶解性 Soluble in NH4OH (50 mg/mL), DMSO, Methanol and slightly soluble in Ethanol. Beilstein 212994 Merck 14,53 GHS危害和防范说明 GHS符号 Hazard Statements H303-H360 May be harmful if swallowed.May damage fertility or the unborn child. Precautionary Statements P201-P280-P202-P308+P313-P405-P501a Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Do not handle until all safety precautions have been read and understood.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations. 安全信息危险类别 61 May cause harm to the unborn child. 安全等级 53-36-45 Avoid exposure - obtain special instructions before use.Wear suitable protective clothing.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). RTECS AC8225000 TSCA 是