CAS 58-46-8; 1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2h-benzo(a)quinolizin-2-on

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货号

品牌

产品名称

规格

包装、参考价格

详情

T794291

MACKLIN

丁苯那嗪

10mM in DMSO

648元/1ml;

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储存：-20°C

T868437

MACKLIN

丁苯那嗪

≥99%

195元/200mg; 580元/1g; 1742元/5g;

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储存：2-8°C

T2839

TCI

Tetrabenazine

>99.0%(T)(HPLC)

970元/200MG; 3180元/1G;

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基本信息

纯度/分析方法	>99.0%(T)(HPLC)
分子式/分子量	C₁₉H₂₇NO₃ = 317.43
外观与形状(20℃)	固体
储存温度	0-10℃
储存在惰性气体下	存放于惰性气体之中
应避免的情况	空气,加热
Reaxys-RN	40090
PubChem物质ID	160871211
Merck Index (14)	9182

技术规格

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 99.0 area%
Purity(Nonaqueous Titration)	min. 99.0 %
Melting point	124.0 to 130.0 ℃

物性(参考值)

熔点

127 ℃

安全信息

图形或危害标志
信号词	警告
危险性说明	H302 : 吞咽有害。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

相关法规

RTECS#

DK2275000

801141

J&K

Tetrabenazine

99%, 一种VMAT抑制剂

377元/200MG; 1505元/1G;

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基本信息

分子式	C₁₉H₂₇NO₃
分子量	317.42
熔点	124-130
MDL编码	MFCD08461052
Beilstein	40090
Merck	14,9182
EINECS 编号	200-383-6
存储条件	Store at 2-8℃

产品描述

Tetrabenazine(Nitoman, Xenazine)主要是一种可逆的、高亲和力的突触前神经元的颗粒小泡吸收单胺的抑制剂，选择性与VMAT-2结合。也能阻止dopamine D2 receptors，但亲和力相对于对VMAT-2的亲和力弱1000倍。

靶点（IC50 & Targe）

Synaptic vesicular amine transporter,

安全信息

图形或危害标志
提示语	Warning
危险说明	H302
防范说明	P262
WGK	3
RTECS	DK2275000

T2952

Sigma-Aldrich

Tetrabenazine

≥98% (HPLC), solid

1908.77元/10 MG; 7054.94元/50 MG;

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产品说明

应用

Tetrabenazine has been used for dopamine uptake assays in mouse brain cells¹. Tetrabenazine has also been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells².

包装

10, 50 mg in glass bottle

生化/生理作用

Tetrabenazine is a reversible type 2 vesicular monoamine transporter (VMAT) inhibitor. It depletes dopamine stores.

特点和优势

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

制备说明

Tetrabenazine is soluble in DMSO at a concentration that is greater than 10 mg/ml and is insoluble in water.

基本信息

经验(实验)分子式	C₁₉H₂₇NO₃
分子量	317.42
Beilstein	40090
EC 号	200-383-6
MDL编号	MFCD08461052
PubChem化学物质编号	329826731
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
溶解性	DMSO: >10 mg/mL H₂O: insoluble
创始人	Roche
储存温度	2-8℃
SMILES string	COc1cc2CCN3C[C@@H](CC(C)C)C(=O)CC3c2cc1OC
InChI	1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m1/s1
InChI key	MKJIEFSOBYUXJB-GDBMZVCRSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

301460

Fluorochem

3-ISOBUTYL-9,10-DIMETHOXY-3,4,6,7-TETRAHYDRO-1H-PYRIDO[2,1-A]ISOQUINOLIN-2(11BH)-ONE

97%

2904元/1g; 8712元/5g; 26136元/25g;

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基本信息

CAS Number	58-46-8
MDL Number	MFCD00042740
Melting Point	127℃

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.