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关键词:       仅模糊查询
CAS: 58-32-2
分子式: C24H40N8O4
分子量: 504.62
沸点: 806.5ºC
熔点: 165-166℃
中文名称: 
双嘧达莫
潘生丁
哌醇啶
双嘧哌胺醇
双嘧啶醇胺
联嘧啶氨醇
双嘧啶胺醇
2,6-双(二乙醇氨基)-4,8-二哌啶基嘧啶并-[5,4-d]嘧啶
英文名称: 
ethanol, 2,2',2'',2'''-((4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)din
itri lo)tetra-
2,2',2'',2'''-(4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyldinitri lo)t
etraethanol
2,6-bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine
anginal
cleridium 150
coronarine
curantyl
dipyridamine
dipyridamol
dipyridamole
dipyridan
dipyudamine
gulliostin
natyl
peridamol
persantin
persantine
piroan
prandiol
pyrimido(5,4-d)pyrimidine, 2,6-bis(bis(2-hydroxyethyl)amino)-4,8-dipiperidino
2,2',2'',2'''-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol
ra 8
Per-santin
usaf ge-12
2,2',2'',2'''-[(4,8-Dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol
2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
展开更多英文名
性质描述: 黄色结晶性粉末。熔点163℃，易溶于氯仿及稀酸，溶于乙醇，微溶于丙酮，几乎不溶于水。无臭，味微苦。
生产方法: 氨基乳清酸（见02470）经环合、氯化、缩合而得。
用途: 冠脉扩张剂，用于治疗心绞痛、心肌梗塞等。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
D824725MACKLIN双嘧达莫98%75元/5g;   245元/25g;   776元/100g;   3277元/500g;   展开
储存：室温
状态：黄色到黄色绿色粉末
折射率：1.666
D795361MACKLIN双嘧达莫10mM in DMSO376元/1ml;   展开
储存：-20°C
D2274TCIDipyridamole>98.0%(T)(HPLC)405元/5G;   1265元/25G;   展开

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C24H40N8O4 = 504.64
外观与形状(20℃)固体
应避免的情况光
Reaxys-RN68373
PubChem物质ID87568711
SDBS (AIST Spectral DB)19363
Merck Index (14)3346
MDL编号MFCD00010555

技术规格

AppearanceLight yellow to Yellow to Orange powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %
Solubility in THFalmost transparency

物性(参考值)

熔点168 ℃
溶解性(可溶于)氯仿

安全信息

图形或危害标志
信号词危险
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H370 : 会损害器官。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P260 : 不要吸入粉尘/ 烟/ 气体/ 烟雾/ 蒸气/ 喷雾。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P308+P311 : 如接触到或有疑虑：呼叫急救中心/医生。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P405 : 存放处须加锁。

相关法规

RTECS#KK7450000
125517J&KDipyridamole98%, 一种磷酸二酯酶抑制剂371元/5G;   1131元/25G;   3724元/100G;   展开

基本信息

分子式C24H40N8O4
分子量504.63
熔点165-166
MDL编码MFCD00010555
Merck13,3381
EINECS 编号200-374-7

产品描述

Dipyridamole是一种磷酸二酯酶抑制剂，通过红细胞和血管内皮细胞，抑制腺苷的摄取和代谢。

靶点（IC50 & Targe）

PDE

参考文献

[1] Klabunde RE. Eur J Pharmacol, 1983, 93(1-2):21-6.

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK2
RTECSKK7450000
TSCA否
Y0000802Dipyridamole for peak identificationEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

磷酸二酯酶 V 选择性抑制剂 (PDE 5)；强效冠脉扩张药物；腺苷转运抑制剂；血小板聚集抑制剂。

包装

Unit quantity: 2 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C24H40N8O4
分子量504.63
MDL编号MFCD00010555
PubChem化学物质编号329831157
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp165-166 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringOCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
InChI1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChI keyIZEKFCXSFNUWAM-UHFFFAOYSA-N
Gene Informationhuman ... PDE10A(10846), PDE1A(5136), PDE1B(5153), PDE1C(5137), PDE2A(5138), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE6A(5145), PDE6B(5158), PDE6C(5146), PDE6D(5147), PDE6G(5148), PDE6H(5149), PDE7A(5150), PDE7B(27115), PDE8A(5151), PDE8B(8622), PDE9A(5152), SLC29A1(2030)

安全信息

象形图GHS07
警示用语：Warning
危险声明H315 - H319 - H335
预防措施声明P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 2
D9766Sigma-AldrichDipyridamole≥98% (HPLC)422.15元/1 G;   1430.65元/5 G;   2351.26元/10 G;   4054.86元/25 G;   展开

产品说明

一般描述

双嘧达莫阻止细胞摄取腺苷。作为一种平衡核苷转运蛋白 1 (ENT1) 抑制剂发挥作用。

应用

双嘧达莫已用于：

  • 进行体外生长抑制试验 (40)
  • 测定其预防子宫肌层收缩的能力 (41)
  • 确定其对烟酰胺腺嘌呤二核苷酸 (NAD +) 诱导的细胞内三磷酸腺苷 (ATP) 水平增加的作用 (42)
  • ，防止烟酰胺核苷 (NR) 诱导的轴突保护作用 (43)

包装

1, 5, 10, 25 g in glass bottle

生化/生理作用

磷酸二酯酶 V 选择性抑制剂 (PDE 5)；强效冠脉扩张药物；腺苷转运抑制剂；血小板聚集抑制剂。

特点和优势

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
该化合物出现在受体分类和信号转导手册的磷酸二酯酶页，点击此处。
该化合物由 Boehringer Ingelheim 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

基本信息

经验(实验)分子式C24H40N8O4
分子量504.63
EC 号200-374-7
MDL编号MFCD00010555
PubChem化学物质编号24277705

产品性质

质量水平200
测定≥98% (HPLC)
形式powder
颜色 yellow
mp165-166 ℃ (lit.)
溶解性DMSO: soluble
ethanol: soluble
创始人Boehringer Ingelheim
储存温度room temp
SMILES stringOCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
InChI1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChI keyIZEKFCXSFNUWAM-UHFFFAOYSA-N
Gene Informationhuman ... CYP1A2(1544), PDE10A(10846), PDE1A(5136), PDE1B(5153), PDE1C(5137), PDE2A(5138), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE6A(5145), PDE6B(5158), PDE6C(5146), PDE6D(5147), PDE6G(5148), PDE6H(5149), PDE7A(5150), PDE7B(27115), PDE8A(5151), PDE8B(8622), PDE9A(5152), SLC29A1(2030)
mouse ... Slc29a1(63959)

安全信息

象形图GHS07
警示用语：Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
D2850000DipyridamoleEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

磷酸二酯酶 V 选择性抑制剂 (PDE 5)；强效冠脉扩张药物；腺苷转运抑制剂；血小板聚集抑制剂。

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C24H40N8O4
分子量504.63
MDL编号MFCD00010555
PubChem化学物质编号329798756
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp165-166 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringOCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
InChI1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChI keyIZEKFCXSFNUWAM-UHFFFAOYSA-N
Gene Informationhuman ... PDE10A(10846), PDE1A(5136), PDE1B(5153), PDE1C(5137), PDE2A(5138), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE6A(5145), PDE6B(5158), PDE6C(5146), PDE6D(5147), PDE6G(5148), PDE6H(5149), PDE7A(5150), PDE7B(27115), PDE8A(5151), PDE8B(8622), PDE9A(5152), SLC29A1(2030)

安全信息

象形图GHS07
警示用语：Warning
危险声明H315 - H319 - H335
预防措施声明P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 2
BP131DipyridamoleBritish Pharmacopoeia (BP) Reference Standard2189.77元/100 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

磷酸二酯酶 V 选择性抑制剂 (PDE 5)；强效冠脉扩张药物；腺苷转运抑制剂；血小板聚集抑制剂。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C24H40N8O4
分子量504.63
EC 号200-374-7
MDL编号MFCD00010555
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
mp165-166 ℃ (lit.)
格式neat
储存温度2-8℃
SMILES stringOCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
InChI1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChI keyIZEKFCXSFNUWAM-UHFFFAOYSA-N
Gene Informationhuman ... PDE10A(10846), PDE1A(5136), PDE1B(5153), PDE1C(5137), PDE2A(5138), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE6A(5145), PDE6B(5158), PDE6C(5146), PDE6D(5147), PDE6G(5148), PDE6H(5149), PDE7A(5150), PDE7B(27115), PDE8A(5151), PDE8B(8622), PDE9A(5152), SLC29A1(2030)

安全信息

象形图GHS07
警示用语：Warning
危险声明H315 - H319 - H335
预防措施声明P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
1220506USPDipyridamoleUnited States Pharmacopeia (USP) Reference Standard3426.58元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

磷酸二酯酶 V 选择性抑制剂 (PDE 5)；强效冠脉扩张药物；腺苷转运抑制剂；血小板聚集抑制剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C24H40N8O4
分子量504.63
MDL编号MFCD00010555
PubChem化学物质编号329749652
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp165-166 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringOCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
InChI1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChI keyIZEKFCXSFNUWAM-UHFFFAOYSA-N
Gene Informationhuman ... PDE10A(10846), PDE1A(5136), PDE1B(5153), PDE1C(5137), PDE2A(5138), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE6A(5145), PDE6B(5158), PDE6C(5146), PDE6D(5147), PDE6G(5148), PDE6H(5149), PDE7A(5150), PDE7B(27115), PDE8A(5151), PDE8B(8622), PDE9A(5152), SLC29A1(2030)

安全信息

象形图GHS07
警示用语：Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
BP1102Dipyridamole impurity standardBritish Pharmacopoeia (BP) Reference Standard1989元/25 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

磷酸二酯酶 V 选择性抑制剂 (PDE 5)；强效冠脉扩张药物；腺苷转运抑制剂；血小板聚集抑制剂。

包装

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C24H40N8O4
分子量504.63
MDL编号MFCD00010555

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
mp165-166 ℃ (lit.)
格式mixture
储存温度2-8℃
SMILES stringOCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
InChI1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChI keyIZEKFCXSFNUWAM-UHFFFAOYSA-N
Gene Informationhuman ... PDE10A(10846), PDE1A(5136), PDE1B(5153), PDE1C(5137), PDE2A(5138), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE6A(5145), PDE6B(5158), PDE6C(5146), PDE6D(5147), PDE6G(5148), PDE6H(5149), PDE7A(5150), PDE7B(27115), PDE8A(5151), PDE8B(8622), PDE9A(5152), SLC29A1(2030)

安全信息

象形图GHS07
警示用语：Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P280 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
079856Fluorochem2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl))tetraethanol95%264元/10g;   638元/25g;   2420元/100g;   展开

基本信息

CAS Number58-32-2
MDL NumberMFCD00010555
Melting Point165-166℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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