[登录] [免费注册]
试剂仪器网
位置:首页 > 资料中心 > 化工字典 > 58-27-5
关键词:       仅模糊查询
CAS: 58-27-5
分子式: C11H8O2
分子量: 172.18
熔点: 105-108℃
中文名称: 
2-甲萘醌
β-甲萘醌
维他命K3
2-甲基-1,4-萘醌
维生素K3
甲萘醌
亚硫酸氢钠甲萘醌
抗出血病维生素
维生素K3标准品
2-甲基萘醌
甲奈醌
2-甲基-1,4-萘二酮
展开更多中文名
英文名称: 
1,4-naphthoquinone,2-methyl-
β-Methyl-1,4-naphthoquinone
1,4-Dihydro-1,4-dioxo-2-methylnaphthalene
Vitamin K0
2-Methyl-[1,4]naphthoquinone
4-Naphthalenedione, 2-methyl-1
2-methyl-4-naphthoquinone
2-methyl-4-naphthalenedione
2-methyl-1,4-naftochinon
2-methyl-1,4-naphthalenedione
beta-methyl naphthoquinone
2-methyl-1,4-naphthochinon
vitamink3
2-methyl-1,4-naphthoquinone
2-methylnaphthoquinone
3-methyl-1,4-naphthoquinone
aquakay
aquinone
hemodal
juva-k
k-thrombyl
k-vitan
kaergona
kanone
kappaxin
karcon
kareon
kativ-g
kayklot
kaykot
kayquinone
kipca
kipca, oil soluble
kipca-oil soluble
klottone
koaxin
kolklot
memodol
menadion
menadione
menaphthon
menaphthone
menaphtone
menaquinone
menaquinone 0
mitenon
mitenone
mnq
nsc 4170
panosine
prokayvit
synkay
Menadione(K3)
thyloquinone
Vitamin K_3
1,4-Naphthalenedione,2-methyl-
usaf ek-5185
Vi-tamin K3
vitamin k2(0)
vitamin k3
展开更多英文名
性质描述: 亮黄色晶体。熔点104-105℃。溶于乙醇、苯、氯仿、四氯化碳和植物油等,不溶于水。遇光或铁质分解变质,能随水蒸气挥发。
生产方法: 有两种生产工艺。1.甲基萘用铬酐氧化而得。将2-甲基萘溶解于冰醋酸中,搅拌冷却到40℃以下,缓缓加入铬酐与等量水的混和液,使温度维持在35-40℃。加毕,在40℃保温0.5h,升温到70℃保温45min,再升温到85℃保温15min,将反应物倾入大量水中,不断搅拌下沉淀出2-甲萘醌。过滤,滤饼反复用水洗,至水溶液无酸味,滤干得2-甲萘醌。收率51%。2-甲基萘也可用重铬酸钠、重铬酸钾氧化收率大致相同。2.由甲苯醌与丁二烯环合得到2-甲基萘氢醌,再经铬酸氧化而得。将甲苯醌加入冰醋酸中溶解,通入丁二烯,在20℃以下通至所需量。密闭静置20h后,加热使剩余的丁二烯逸出,继续加热至110℃左右回流3h,再减压蒸馏回收冰醋酸约30%。然后冷却至40℃以下,缓缓加入铬酸与等量水的混合液,使温度保持在65-70℃,加毕,在70-80保温1h而生成甲萘醌。
用途: 该品与亚硫酸氢钠加成即得维生素K3。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
M794497MACKLIN维生素K310mM in DMSO159元/1ml;   556元/5ml;   展开
储存:-20°C
状态:液体
M813095MACKLIN维生素K3分析对照品, ≥99%(HPLC)205元/250mg;   展开
储存:室温
状态:黄色到黄绿色粉末
M813096MACKLIN甲萘醌98%36元/5g;   92元/25g;   302元/100g;   1135元/500g;   展开
储存:室温,避光
状态:黄色到黄绿色粉末
M0373TCI2-Methyl-1,4-naphthoquinone>98.0%(T)(HPLC)460元/25G;   2310元/250G;   展开

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C11H8O2 = 172.18
外观与形状(20℃)固体
应避免的情况
Reaxys-RN1908453
PubChem物质ID87572439
SDBS (AIST Spectral DB)2623
Merck Index (14)5831
MDL编号MFCD00001681

技术规格

AppearanceLight yellow to Yellow to Green powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Cerium redox Method)min. 98.0 %
Melting point105.0 to 108.0 ℃
Solubility in Toluenealmost transparency

物性(参考值)

熔点107 ℃

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#QL9100000
999896J&K2-Methyl-1,4-naphthoquinone98%63元/5G;   202元/25G;   607元/100G;   展开

基本信息

分子式C11H8O2
分子量172.18
熔点105-107
MDL编码MFCD00001681
Beilstein1908453
Merck14,5831
EINECS 编号200-372-6

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
RTECSQL9100000
TSCA
A13593Alfa Aesar2-Methyl-1,4-naphthoquinone98%778元/10g;   2611元/50g;   9447元/250g;   展开

应用
2-Methyl-1,4-naphthoquinone is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations. 2-Methyl-1,4-naphthoquinone is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. 2-Methyl-1,4-naphthoquinone can be used as an oxidative injury inducing agent.

备注
Keep container tightly closed. Store away from oxidizing agents.

基本信息

MDL
MFCD00001681

EINECS
200-372-6

分子式
C11H8O2

分子量
172.18

熔点
104-107°

灵敏度
Light Sensitive. Ambient temperatures.

形态
Powder

溶解性
Soluble in methanol

Beilstein
1908453

Merck
14,5831

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H315-H319-H335
Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
26-36/37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.

欧盟危险品标志

RTECS
QL9100000

TSCA

C12718Alfa Aesar2-Methyl-1,4-naphthoquinone98%657元/5g;   1324元/25g;   5384元/100g;   展开

基本信息

Ref#
12718

MDL
1681

分子式
C11 H8 O2

分子量
172.18

1381006USPMenadioneUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C11H8O2
分子量172.18
Beilstein1908453
MDL编号MFCD00001681
PubChem化学物质编号329750354
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp105-107 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC1=CC(=O)c2ccccc2C1=O
InChI1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
InChI keyMJVAVZPDRWSRRC-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08GHS09
警示用语:Danger
危险声明H302 - H315 - H319 - H334 - H335 - H410
预防措施声明P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
M0300000MenadioneEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Menadione, a fat-soluble vitamin, is an antihemorrhagic compound that plays an important role in blood coagulation. It takes part in blood clotting by activating prothrombin, the thrombin precursor.

应用

Menadione may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometry techniques.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C11H8O2
分子量172.18
Beilstein1908453
MDL编号MFCD00001681
PubChem化学物质编号329817767
NACRESNA.24

产品性质

生物来源synthetic
等级pharmaceutical primary standard
agencyEP
形式solid
manufacturer/tradenameEDQM
technique(s)gas chromatography (GC): suitable
liquid chromatography (LC): suitable
mp105-107 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC1=CC(=O)c2ccccc2C1=O
InChI1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
InChI keyMJVAVZPDRWSRRC-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08GHS09
警示用语:Danger
危险声明H302 - H315 - H319 - H334 - H335 - H410
预防措施声明P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
M5625Sigma-AldrichMenadionecrystalline502.19元/25 G;   1702.14元/100 G;   展开

产品说明

应用

甲萘醌用于产生活性氧(ROS),然后进行流式细胞术分析。它还用于微生物评估,例如检测苛求菌。

包装

25, 100 g in glass bottle

生化/生理作用

甲萘醌是一种芳香族多环酮。它是维生素K合成的前体。甲萘醌可转化为甲基萘醌-4(维生素K3的活性代谢产物)。甲萘醌通过无效的氧化还原循环诱导产生活性氧来介导细胞死亡。
甲萘醌(维生素K3)是1,4-萘醌的合成类似物,在2-位有一个甲基。甲萘醌是磷酸酶抑制剂,也是线粒体DNA聚合酶γ (pol γ)抑制剂。甲萘醌可用作氧化损伤(自由基生成剂)诱导剂。

基本信息

经验(实验)分子式C11H8O2
分子量172.18
Beilstein1908453
EC 号200-372-6
MDL编号MFCD00001681
PubChem化学物质编号24897023
NACRESNA.79

产品性质

质量水平200
生物来源synthetic
测定≥98.0% (HPLC)
形式crystalline
technique(s)HPLC: suitable
颜色faint green to green-yellow
mp105-107 ℃ (lit.)
溶解性oil: soluble
储存温度room temp
SMILES stringCC1=CC(=O)c2ccccc2C1=O
InChI1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
InChI keyMJVAVZPDRWSRRC-UHFFFAOYSA-N
Gene Informationhuman ... NQO1(1728)

安全信息

象形图GHS07GHS08GHS09
警示用语:Danger
危险声明H302 - H315 - H319 - H334 - H335 - H410
预防措施声明P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
M9429Sigma-AldrichMenadionemeets USP testing specifications627.31元/25 G;   1652.94元/100 G;   展开

产品说明

一般描述

甲萘醌(维生素 K3)是维生素 K 的合成形式,具有与维生素 K1、K2 相似的结构。维生素 K1、K2 和 K3 具有生物活性。水溶性形式的甲萘醌用于猪和家禽日粮。

应用

甲萘醌已用于:

  • 处理 HL-60 细胞作为流式细胞术的凋亡阳性对照
  • 作为受精后 24h 后转基因胚胎中的氧化应激诱导剂
  • 处理 HaCaT 细胞系,用于定量总谷胱甘肽和氧化谷胱甘肽

包装

25, 100 g in glass bottle

生化/生理作用

甲萘醌是一种氧化应激诱导剂。

基本信息

经验(实验)分子式C11H8O2
分子量172.18
Beilstein1908453
EC 号200-372-6
MDL编号MFCD00001681
PubChem化学物质编号24897335
NACRESNA.21

产品性质

质量水平200
生物来源synthetic (organic)
agencyUSP/NF
meets USP testing specifications
测定98.5-101.0% dry basis
形式solid
mp105-107 ℃ (lit.)
application(s)pharmaceutical (small molecule)
SMILES stringCC1=CC(=O)c2ccccc2C1=O
InChI1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
InChI keyMJVAVZPDRWSRRC-UHFFFAOYSA-N
Gene Informationhuman ... NQO1(1728)

安全信息

象形图GHS07GHS08GHS09
警示用语:Danger
危险声明H302 - H315 - H319 - H334 - H335 - H410
预防措施声明P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
PHR1411SupelcoMenadionePharmaceutical Secondary Standard; Certified Reference Material1327.41元/500 MG;   展开

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Menadione is an antihemorrhagic compound and it finds application in blood clotting and bone metabolism as an essential cofactor. Additionally, at relatively higher dose, menadione exhibits antitumor activity on several human cancer cells.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Menadione may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometric methods.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA2475 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C11H8O2
分子量172.18
Beilstein1908453
EC 号200-372-6
MDL编号MFCD00001681
PubChem化学物质编号329823383
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp105-107 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to PhEur M0300000
traceable to USP 1381006
储存温度2-8℃
SMILES stringCC1=CC(=O)c2ccccc2C1=O
InChI1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
InChI keyMJVAVZPDRWSRRC-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08GHS09
警示用语:Danger
危险声明H302 - H315 - H319 - H334 - H335 - H410
预防措施声明P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
47775SupelcoMenadione (K3)analytical standard471.31元/1000 MG;   展开

产品说明

一般描述

甲萘醌是一种促血栓形成的化合物,属于维生素K类化合物,其对于凝血酶原和其他凝血因子的生物合成是必不可少的。它可用作细胞培养和体内研究中的模型醌。 它是叶绿醌的分解代谢产物,是大鼠组织中甲萘醌4的循环前体。
甲萘醌(K3)是一种脂溶性维生素前体,它是肠中口服叶绿醌(维生素k1)的分解代谢产物。

应用

有关合适仪器技术的更多信息,请参考产品分析证书。如需进一步支持,请联系技术服务部门。
甲萘醌(K3)可用作液相色谱技术定量测定生物体液中分析物的分析参考标准品。

基本信息

经验(实验)分子式C11H8O2
分子量172.18
Beilstein1908453
EC 号200-372-6
MDL编号MFCD00001681
PubChem化学物质编号24871411

产品性质

质量水平100
等级analytical standard
CofAcurrent certificate can be downloaded
特点standard type fat soluble vitamin
包装ampule of 1000 mg
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp105-107 ℃ (lit.)
application(s)pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products
格式neat
储存温度2-30℃
SMILES stringCC1=CC(=O)c2ccccc2C1=O
InChI1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
InChI keyMJVAVZPDRWSRRC-UHFFFAOYSA-N
Gene Informationhuman ... NQO1(1728)

安全信息

象形图GHS07GHS08GHS09
警示用语:Danger
危险声明H302 - H315 - H319 - H334 - H335 - H410
预防措施声明P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
VIT-018NAccuStandardVitamin K3428元/100mg;   展开
Menadione2-甲基-1,4-萘醌58-27-5
049845FluorochemMenadione98%220元/1g;   396元/25g;   1430元/100g;   展开

基本信息

CAS Number58-27-5
MDL NumberMFCD00001681
Density1.38

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H400: Very toxic to aquatic life.
H410: Very toxic to aquatic life with long lasting effects.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace.
P273: Avoid release to the environment.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P391: Collect spillage.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
CAS号首数字顺序排列: 1 2 3 4 5 6 7 8 9