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CAS: 5784-45-2
分子式: C8H5ClN2
分子量: 164.59
中文名称: 
1-氯代酞嗪
英文名称: 
1-Chlorophthalazine
生产方法: 由萘经氧化、环合、消除、氯化而得。1.氧化、环合在搅拌下,将萘、高锰酸钾加入氢氧化钠溶液中,在90-120℃反应约3h。过滤,滤液加硫酸肼至pH为7,回流1h,用30%硫酸调节至pH为3,过滤,水洗,干燥,得1-羟基-4-羧基酞嗪。2.消除、氯化将硝基苯加到1-羟基-4-羧基酞嗪中搅拌,慢慢加热到200℃,保温到二氧化碳放尽,冷却,过滤,用四氯化碳洗涤滤饼,干燥,得1-羟基酞嗪。将其与三氯氧磷在87-89℃反应半小时,反应液冰析,用10%氢氧化钠溶液调节至pH为7.5,过滤,水洗,干燥,得1-氯代酞嗪。
用途: 降压药肼苯哒嗪的中间体。1-氯代酞嗪与水合肼反应即得肼苯哒嗪。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
H27143Alfa Aesar1-Chlorophthalazine97%1749元/1g;   11706元/10g;   展开

应用
1-Chlorophthalazine, is used as a pharmaceutical intermediate and are used as medical isotopes.

备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away strong oxidizing agents. Water, heat, moisture sensitive.

基本信息

MDL
MFCD00024141

分子式
C8H5N2Cl

分子量
164.59

熔点
109-112°

灵敏度
Store under Nitrogen. Keep Cold. Moisture Sensitive.

形态
Powder

溶解性
Insoluble in water. Soluble in dichloromethane, ethanol and methanol.

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

TSCA

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