CAS 57368-84-0; 2-chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

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CAS:

57368-84-0

分子式:

C₁₂H₁₄ClNO₂

分子量:

239.7

沸点:

464.82 °C at 760 mmHg (Predicted)

英文名称:

2-chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

electrophilic scout fragment

scout fragment for targetable cysteine

kb02

2-chloro-1-(6-methoxy-3,4-dihydroquinolin-1(2h)-yl)ethan-1-one

1-(chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl methyl ether

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货号

品牌

产品名称

规格

包装、参考价格

779683

MACKLIN

2-氯-1-(6-甲氧基-1,2,3,4-四氢喹啉-1-基)乙-1-酮

95%

890元/100mg; 1657元/250mg; 3363元/1g;

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储存：2-8°C, 密封, 干燥

912131

Sigma-Aldrich

2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

≥95%

1504.95元/100 MG;

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产品说明

应用

2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile, or "scout" fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC^® molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery.

其他说明

Technology Spotlight: Proteomic Ligandability Assessment

The Proteome-Wide Potential for Reversible Covalency at Cysteine

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Proteome-wide covalent ligand discovery in native biological systems

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₁₂H₁₄ClNO₂
分子量	239.70
MDL编号	MFCD09376367

产品性质

质量水平	100
测定	≥95%
形式	chunks
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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