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CAS: 57-83-0
分子式: C21H30O2
分子量: 314.46
熔点: 128-132℃
中文名称: 
黄体酮
孕酮
助孕素
激孕酮
英文名称: 
3,20-pregnene-4
4-pregnene-3,20-dione
agolutin
Δ4-pregnene-3,20-dione
beta-progesterone
Crinone
bio-luton
Lugesteron
corlutin
Luteum
corlutina
Lutociclina
corluvite
progesterone(INN)
corporin
Progesteron
corpus luteum hormone
4-Pregnen-3,20-dion
delta(4)-pregnene-3,20-dione
(8S,10R,13S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
delta(sup 4)-pregnene-3,20-dione
delta(sup4)-pregnene-3,20-dione
flavolutan
fologenon
gesterol
gesterol 100
gestone
gestormone
gestron
glanducorpin
gynlutin
gynoluton
gynolutone
hormoflaveine
hormoluton
lingusorbs
Progstin
lipo-lutin
lucorteum sol
luteal hormone
luteinique
luteocrin normale
luteodyn
luteogan
luteohormone
luteol
luteopur
luteosan
luteostab
luteovis
lutex
lutidon
lutin
lutocyclin
lutocyclin m
lutocylin
lutoform
lutogyl
lutren
lutromone
nalutron
nsc-9704
percutacrine luteinique
piaponon
pregn-4-ene-3,20-dione
pregnene-3,20-dione
pregnenedione
primolut
progekan
progestasert
progesterol
progesterone
progesteronum
progestin
progestone
progestron
projestaject
prolets
prolidon
proluton
prolutone
protormone
syngesterone
syngestrets
synovex s
syntolutan
展开更多英文名
性质描述: 白色结晶或粉末。有两种于互变的结晶体,α型为柱状,β型为针状,具有相同生理活性。熔点(α型)127-131℃,(β型)121℃。溶于醇、丙酮和二氧六环微溶于植物油,不溶于水。在空气中稳定。
生产方法: 由妊烯醇酮氧化得到。将干燥的甲苯加入干燥的反应锅内,加入环已酮及妊烯醇酮,搅拌溶解,蒸甲苯脱水至尽,迅速加入异丙醇铝,于115℃氧化反应2h,冷却至80℃左右,在搅拌下加入5%稀硫酸,静置分层,分去水层,甲苯层用水洗至中性后进行水蒸气蒸馏,蒸出甲苯及环已酮。冷却,过滤,滤渣用石油醚搅成浆状,过滤,以石油醚洗涤,干燥得黄体酮粗品。粗品溶于乙醇,用活性炭脱色,重结晶成品,收率80%。
用途: 激素类药。主要促进并维持妊娠前期的子宫变化,用于习惯性流产,月经不调等。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
P875753MACKLIN黄体酮标准品100μg/ml288元/1ml;   展开
储存:室温
状态:液体
折射率:182 ° (C=2, Dioxane)
P875697MACKLIN甲醇中黄体酮溶液标准物质10.0ng/μL268元/2ml;   展开
储存:室温
状态:白色至浅灰色粉末
物化性质:液质校准用
折射率:182 ° (C=2, Dioxane)
P815834MACKLIN黄体酮98%32元/1g;   83元/5g;   203元/25g;   602元/100g;   2693元/500g;   展开
储存:室温
状态:白色至浅灰色粉末
折射率:182 ° (C=2, Dioxane)
P728851MACKLIN孕酮溶液1.0 mg/mL in acetonitrile498元/1ml;   展开
储存:−20°C
折射率:182 ° (C=2, Dioxane)
260412J&KProgesterone98%176元/5G;   428元/25G;   展开

基本信息

分子式C21H30O2
分子量314.46
熔点126-132
MDL编码MFCD00003658
Beilstein1915950
EINECS 编号200-350-6

生化/生理作用

诱导子宫内皮细胞的成熟和分泌活动;抑制排卵。孕酮与乳腺癌的病因有关。

其他说明

由卵巢黄体产生的类固醇激素。

安全信息

图形或危害标志
提示语Warning
危险说明H351
H361
防范说明P280
WGK3
RTECSTW0175000
R10798Alfa AesarProgesterone Standard solution100ppm210元/1ml;   展开

安全信息

危险等级
3

P0130Sigma-AldrichProgesterone≥99%2183.98元/25 G;   7794.72元/100 G;   展开

产品说明

包装

25, 100 g in poly bottle

生化/生理作用

诱导子宫内皮细胞的成熟和分泌活动;抑制排卵。孕酮与乳腺癌的病因有关。

特点和优势

该化合物由 Abbott开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单, 请单击此处。

其他说明

由卵巢黄体产生的类固醇激素。

基本信息

经验(实验)分子式C21H30O2
分子量314.46
Beilstein1915950
EC 号200-350-6
MDL编号MFCD00003658
PubChem化学物质编号24278618
NACRESNA.77

产品性质

质量水平200
生物来源synthetic (organic)
无菌性non-sterile
测定≥99%
形式powder
mp128-132 ℃ (lit.)
溶解性chloroform: 50 mg/mL, clear, colorless to light yellow
web metadata keyword.default4-Pregnene-3,20-dione; Pregn-4-en-3,20-dione; 57-83-0; natural steroid hormone; endometrium; progestogen; embryogenesis; endometrial; neurosteroid; neuroprotective; apoptosist regulation; progesterone receptor;
创始人Abbott
运输ambient
储存温度room temp
SMILES stringCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChI keyRJKFOVLPORLFTN-LEKSSAKUSA-N
Gene Informationhuman ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

安全信息

象形图GHS08
警示用语:Danger
危险声明H351 - H360FD - H362
预防措施声明P202 - P260 - P263 - P264 - P270 - P308 + P313
危险分类Carc. 2 - Lact. - Repr. 1A
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
个人防护装备Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
V900699Sigma-AldrichProgesteroneVetec, reagent grade, 98%312.9元/5 G;   展开

产品说明

包装

5, 25 g in poly bottle

生化/生理作用

诱导子宫内皮细胞的成熟和分泌活动;抑制排卵。孕酮与乳腺癌的病因有关。
孕酮是维持妊娠的激素。它对几乎所有哺乳动物的胚胎形成、发育和存活都是必不可少的。这种激素通过孕激素受体发挥作用,孕激素受体在整个妊娠期特异表达于子宫内膜间质。已知它通过肌肉注射给药可预防早产。

其他说明

由卵巢黄体产生的类固醇激素。

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

经验(实验)分子式C21H30O2
分子量314.46
Beilstein1915950
EC 号200-350-6
MDL编号MFCD00003658
PubChem化学物质编号329830071

产品性质

等级reagent grade
产品线Vetec
测定98%
mp128-132 ℃ (lit.)
SMILES stringCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChI keyRJKFOVLPORLFTN-LEKSSAKUSA-N
Gene Informationhuman ... PGR(5241)

安全信息

象形图GHS08
警示用语:Danger
危险声明H351 - H360FD - H362
预防措施声明P202 - P260 - P263 - P264 - P270 - P308 + P313
危险分类Carc. 2 - Lact. - Repr. 1A
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
374675FluorochemPREGN-4-ENE-3,20-DIONE>98.0%(HPLC)660元/5g;   1826元/25g;   展开

基本信息

CAS Number57-83-0
MDL NumberMFCD00003658
Melting Point131℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H351: Suspected of causing cancer ..
防范说明 P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P281: Use personal protective equipment as required.
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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