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CAS: 550-99-2
分子式: C14H14N2·HCl
分子量: 246.74
熔点: 254-260℃
中文名称: 
萘甲唑啉盐酸盐
2-(1-萘甲基)咪唑啉盐酸盐
鼻眼净
盐酸苯甲唑啉
英文名称: 
2-(1-naphthylmethyl)-2-imidazolin monohydrochloride
4,5-dihydro-2-(1-naphthalenylmethyl)-1h-imidazol monohydrochloride
2-(1-naphthylmethyl)-2-imidazoline hydrochloride
2-(1-naphthylmethyl)imidazoline hydrochloride
albalon liquifilm
clera
coldan
naphazoline chloride
naphazoline hydrochloride
naphcon
naphcon forte
naphthasolium chloride
niazol
privine hydrochloride
prizole hydrochloride
rhinantin
rhinoperd
sanorin-spofa
strictylon
stricylon
vasocon
展开更多英文名
性质描述: 白色结晶性粉末。熔点255-260℃。在100毫升水中可溶解本品40克。易溶于乙醇,微溶于氯仿,不溶于苯和乙醚。无臭,味苦。
生产方法: 由α-萘乙酸与乙二胺缩合、环合制成2-(1-萘甲基)咪唑啉(C14H14N2,[835-31-4]),然后成盐而得萘甲唑啉盐酸盐。将α-乙酸和乙二胺加入反应锅内,搅拌加热至120℃,反应1小时后,再升温至130℃,反应1小时。蒸除乙二胺和水后进行减压蒸馏,收集180-240℃(1.33-4千帕)馏分,得2-(1-萘甲基)咪唑啉。然后将其溶于丙酮和乙醇的混合液,在10-12℃通入氯化氢气体成盐,即生成萘甲唑啉盐酸盐结晶。
用途: 本品为血管收缩药。大鼠皮下注射LD50为385毫克/公斤。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
N792702MACKLIN萘甲唑啉盐酸盐10mM in DMSO428元/1ml;   展开
储存:-20°C
N814855MACKLIN萘甲唑啉盐酸盐99%30元/5g;   83元/25g;   299元/100g;   1485元/500g;   展开
储存: 室温,干燥,密封
状态:白色到灰白色粉末
N0542TCINaphazoline Hydrochloride>99.0%(T)310元/10G;   展开

基本信息

纯度/分析方法>99.0%(T)
分子式/分子量C14H14N2・HCl = 246.74
外观与形状(20℃)固体
Reaxys-RN3716843
PubChem物质ID87573865
Merck Index (14)6368
MDL编号MFCD00012554

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 95.0 area%
Purity(Nonaqueous Titration)min. 99.0 %
Solubility in Wateralmost transparency

物性(参考值)

熔点258 ℃
水溶性可溶
溶解性(可溶于)乙醇
溶解性(微溶于)氯仿
溶解性(不溶于)乙醚,苯

安全信息

图形或危害标志
信号词危险
危险性说明H300 : 吞咽致命。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P310 + P330 : 如误吞咽:立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#NJ4375000

运输信息

UN编号UN2811
类别6.1
包装类别 II
监管条件代码(*)
506932J&KNaphazoline Hydrochloride99%, 一种眼血管收缩剂, 是咪唑啉衍生物336元/25G;   1007元/100G;   4029元/500G;   展开

基本信息

分子式C14H14N2·HCl
分子量246.74
熔点258-260
MDL编码MFCD00012554
Beilstein3716843
Merck14,6368
EINECS 编号208-989-2

产品描述

Naphazoline HCl 是一种眼部血管收缩剂,是咪唑啉衍生的拟交感胺类。

靶点(IC50 & Targe)

Adrenergic Receptor

安全信息

图形或危害标志
提示语Danger
危险说明H300
防范说明P264
P301+P310
UN号码2811
危险分类6.1
包装等级II
WGK3
RTECSNJ4375000
TSCA
B24161Alfa Aesar2-(1-Naphthylmethyl)-2-imidazoline hydrochloride99%796元/25g;   2373元/100g;   9495元/500g;   展开

应用
Naphazoline hydrochloride produces ionotropic effects via α-adrenoceptor stimulation. It is an activator of AR and Nischarin. It is used as a nasal decongestant and ocular vasoconstrictor.

备注
Store in a cool, dry place in tightly closed container. Store at room temperature. Incompatible with oxidizing agents.

基本信息

MDL
MFCD00012554

EINECS
208-989-2

分子式
C14H14N2?HCl

分子量
246.74

熔点
257-261°

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in water 170 g/L, alcohol, DMSO, ethanol.

Beilstein
3716843

Merck
14,6368

GHS危害和防范说明

GHS符号

Hazard Statements
H300
Fatal if swallowed.

Precautionary Statements
P264-P270-P301+P310a-P321-P405-P501a
Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Do not eat, drink or smoke when using this product.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
6.1

包装组
II

危险类别
25
Toxic if swallowed.

安全等级
20-36-45
When using do not eat or drink.Wear suitable protective clothing.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

RTECS
NJ4375000

TSCA

C17966Alfa Aesar2-(1-Naphthylmethyl)-2-imidazoline hydrochloride99%1166元/25g;   3637元/100g;   展开

基本信息

Ref#
17966

MDL
12554

分子式
C14 H14 N2 . Cl H

分子量
246.74

安全信息

危险等级
6.1

包装组
II

1457006USPNaphazoline HydrochlorideUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

α-肾上腺素受体激动剂;咪唑啉受体激动剂;血管收缩剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C14H14N2 · HCl
分子量246.74
MDL编号MFCD00012554
PubChem化学物质编号329750527
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCl.C1CN=C(Cc2cccc3ccccc23)N1
InChI1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H
InChI keyDJDFFEBSKJCGHC-UHFFFAOYSA-N
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
N0080000Naphazoline HydrochlorideEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

α-肾上腺素受体激动剂;咪唑啉受体激动剂;血管收缩剂。

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C14H14N2 · HCl
分子量246.74
MDL编号MFCD00012554
PubChem化学物质编号329818398
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCl.C1CN=C(Cc2cccc3ccccc23)N1
InChI1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H
InChI keyDJDFFEBSKJCGHC-UHFFFAOYSA-N
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
N5504Sigma-AldrichNaphazoline Hydrochloride877.11元/25 G;   展开

产品说明

生化/生理作用

盐酸萘甲唑啉是一种拟交感神经药。它也被认为是一种结膜减充血剂。
α-肾上腺素受体激动剂;咪唑啉受体激动剂;血管收缩剂。

特点和优势

该化合物由Allergan开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处。

基本信息

经验(实验)分子式C14H14N2 · HCl
分子量246.74
EC 号208-989-2
MDL编号MFCD00012554
PubChem化学物质编号24278592
NACRESNA.77

产品性质

形式powder
质量水平100
创始人Allergan
SMILES stringCl.C1CN=C(Cc2cccc3ccccc23)N1
InChI1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H
InChI keyDJDFFEBSKJCGHC-UHFFFAOYSA-N
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
个人防护装备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
PHR1836SupelcoNaphazoline HydrochloridePharmaceutical Secondary Standard; Certified Reference Materialr1518.26元/500 MG;   展开

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

α-肾上腺素受体激动剂;咪唑啉受体激动剂;血管收缩剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC2111 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C14H14N2 · HCl
分子量246.74
EC 号208-989-2
MDL编号MFCD00012554
PubChem化学物质编号329823630

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to PhEur N0080000
traceable to USP 1457006
储存温度2-8℃
SMILES stringCl.C1CN=C(Cc2cccc3ccccc23)N1
InChI1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H
InChI keyDJDFFEBSKJCGHC-UHFFFAOYSA-N
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
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