CAS 549-18-8; 阿米替林盐酸盐; 1-propanamine, 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n,n-dimet

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货号

品牌

产品名称

规格

包装、参考价格

详情

A0908

TCI

Amitriptyline Hydrochloride

>98.0%(T)(HPLC)

750元/25G;

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基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₂₀H₂₃N・HCl = 313.87
外观与形状(20℃)	固体
应避免的情况	光
相关CAS RN	50-48-6
Reaxys-RN	4164595
PubChem物质ID	87562417
Merck Index (14)	487
MDL编号	MFCD00012537

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	195.0 to 199.0 ℃
Solubility in Water	almost transparency

物性(参考值)

熔点	195 ℃
水溶性	可溶

安全信息

图形或危害标志
信号词	危险
危险性说明	H301 : 吞咽会中毒。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。 P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。 P405 : 存放处须加锁。

相关法规

RTECS#

HO9450000

运输信息

UN编号	UN2811
类别	6.1
包装类别	III
监管条件代码(*)

296982

J&K

Amitriptyline Hydrochloride

98%, 一种二苯并环庚烯衍生物, 三环抗抑郁剂(TCA)

898元/25G;

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基本信息

分子式	C₂₀H₂₃N·HCl
分子量	313.86
熔点	195-199
MDL编码	MFCD00012537
Beilstein	4164595
Merck	14,487
EINECS 编号	208-964-6
存储条件	Store at 2-8℃

产品描述

Amitriptyline HCl 是一种三环抗抑郁药，抑制5-羟色胺受体，去甲肾上腺素受体， 5-HT4， 5-HT2和sigma 1受体， IC50分别为3.45 nM， 13.3 nM， 7.31 nM， 235 nM和287 nM。

靶点（IC50 & Targe）

5-HT,3.45nM

5-HT2,235nM

5-HT4,7.31nM

Norepinephrine receptor,13.3nM

σ1,287nM

体外研究

Amitriptyline抑制毛喉素刺激的环AMP聚集，在完整CHO/DOR细胞中EC50值为16.2 μM。Amitriptyline浓度依赖性刺激ERK1/2和GSK-3β磷酸化作用，CHO/DOR细胞中EC50值为9.0 μM。Amitriptyline (15 μM)刺激C6细胞中ERK1/2磷酸化。Amitriptyline (30 μM)抑制毛喉素刺激的腺苷酸环化酶活性，并拮抗大鼠伏核中(−)-U50,488的抑制作用。[5] Amitriptyline结合到TrkA和TrkB的胞外结构域，并促进TrkA-TrkB受体异源二聚化。Amitriptyline (< 500 nM)促进初级神经元中TrkA自身磷酸化，并诱导PC12细胞中神经突增生。Amitriptyline选择性保护T17细胞免于细胞凋亡，EC50为50 nM。[6]

体内研究

在小鼠中，Amitriptyline (15 mg/kg, i.p.)激活TrkA和TrkB受体，并显著减少红藻氨酸引起的神经元细胞死亡。[6] Amitriptyline (15 mg/kg 和30 mg/kg, i.p.)剂量依赖性减少小鼠强迫性游泳测试(FST)中的不动时间。小鼠强迫性游泳测试(FST)中，Amitriptyline (15 mg/kg, i.p.)使小鼠不动时间现出显著的24-h节律性。[7] Amitriptyline (1 mg/kg和3 mg/kg)显著增加小鼠在新笼子实验中总的行走距离。Amitriptyline (10 mg/kg p.o.，每天两次)大大减弱小鼠体内对8-OHDPAT和mCPP的低体温响应。Amitriptyline (10 mg/kg p.o.，每天两次)显著降低小鼠大脑皮层中大约20%的血清素转运体密度。[8]

参考文献

[1] Vaishnavi SN, et al. Biol Psychiatry, 2004, 55(3), 320-322.

[2] Nguyen T, et al. Mol Pharmacol, 2001, 59(3), 427-433.

[3] Rauser L, et al. J Pharmacol Exp Ther, 2001, 299(1), 83-89.

[4] Werling LL, et al. Exp Neurol, 2007, 207(2), 248-257.

[5] Onali P, et al. J Pharmacol Exp Ther, 2010, 332(1), 255-265.

[6] Jang SW, et al. Chem Biol, 2009, 16(6), 644-656.

[7] Ushijima K, et al. J Pharmacol Exp Ther, 2005, 315(2), 764-770.

[8] Troelsen KB, et al. Psychopharmacology (Berl), 2005, 181(4

安全信息

图形或危害标志
提示语	Danger
危险说明	H301 H319 H410
防范说明	P273 P301+P310 P305+P351+P338 P501
UN号码	2811
危险分类	6.1
包装等级	III
WGK	3
RTECS	HO9450000

PHR1384

Supelco

Amitriptyline Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

1359.83元/1 G;

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产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amitriptyline hydrochloride is a drug, and a tricyclic antidepressant with anticholinergic activity. It is widely used in combination with chlordiazepoxide 7-chloro-2-(methyl-amino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Amitriptyline hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography.

生化/生理作用

三环抗抑郁剂；抑制分别具有 100nM 和 14.7nM K_is 的去甲肾上腺素和 5-羟色胺转运蛋白；对 α₁-肾上腺素受体、5-羟色胺和毒蕈碱型乙酰胆碱受体具有高度的体外亲和力。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA1640 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₂₀H₂₃N · HCl
分子量	313.86
EC 号	208-964-6
MDL编号	MFCD00012537
PubChem化学物质编号	329823361
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to BP 16 traceable to PhEur Y0000563 traceable to USP 1029002
储存温度	2-30℃
SMILES string	Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI	1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key	KFYRPLNVJVHZGT-UHFFFAOYSA-N
Gene Information	human ... SLC6A2(6530), SLC6A4(6532)

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H319 - H361d - H410
预防措施声明	P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
危险分类	Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0000563

Amitriptyline Hydrochloride

European Pharmacopoeia (EP) Reference Standard

1259.15元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₀H₂₃N · HCl
分子量	313.86
MDL编号	MFCD00012537
PubChem化学物质编号	329831024
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI	1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key	KFYRPLNVJVHZGT-UHFFFAOYSA-N
Gene Information	human ... SLC6A2(6530), SLC6A4(6532)

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H319 - H361d - H410
预防措施声明	P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
危险分类	Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

A8404

Sigma-Aldrich

Amitriptyline Hydrochloride

≥98% (TLC), powder

552.83元/10 G; 1215.53元/25 G; 3340.11元/100 G; 5883.36元/250 G;

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产品说明

应用

盐酸阿密曲替林已用于：

研究其作为抗抑郁药对酸性鞘磷脂酶转基因(t-ASM)小鼠社会行为和记忆的影响
分析其作为三环类抗抑郁药物对人全血中糖皮质受体功能的影响
研究其作为抗抑郁药对氯喹诱导小鼠搔抓和运动行为的影响

生化/生理作用

三环抗抑郁剂；抑制分别具有 100nM 和 14.7nM K_is 的去甲肾上腺素和 5-羟色胺转运蛋白；对 α₁-肾上腺素受体、5-羟色胺和毒蕈碱型乙酰胆碱受体具有高度的体外亲和力。
盐酸阿密曲替林(Amitriptyline)可用于治疗焦虑、躁郁和更年期抑郁症。它具有抗组胺、抗胆碱和抗血清素特性。盐酸阿密曲替林是两亲性药物，具有神经抑制活性。

特点和优势

粉末的保质期至少为三年。

基本信息

经验(实验)分子式	C₂₀H₂₃N · HCl
分子量	313.86
EC 号	208-964-6
MDL编号	MFCD00012537
PubChem化学物质编号	24278073
NACRES	NA.77

产品性质

质量水平	200
测定	≥98% (TLC)
形式	powder
颜色	white to off-white
溶解性	H₂O: soluble ethanol: soluble
创始人	Bristol-Myers Squibb
储存温度	2-8℃
SMILES string	Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI	1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key	KFYRPLNVJVHZGT-UHFFFAOYSA-N
Gene Information	human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), SLC6A2(6530), SLC6A4(6532)

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H319 - H361d - H410
预防措施声明	P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
危险分类	Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

1029002

USP

Amitriptyline Hydrochloride

United States Pharmacopeia (USP) Reference Standard

3231.47元/200 MG;

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产品说明

一般描述

生化/生理作用

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₀H₂₃N · HCl
分子量	313.86
MDL编号	MFCD00012537
PubChem化学物质编号	329749005
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI	1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key	KFYRPLNVJVHZGT-UHFFFAOYSA-N
Gene Information	human ... SLC6A2(6530), SLC6A4(6532)

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H319 - H361d - H410
预防措施声明	P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
危险分类	Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

BP016

Amitriptyline Hydrochloride

British Pharmacopoeia (BP) Reference Standard

1916.08元/150 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

包装

Unit quantity: 150 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₀H₂₃N · HCl
分子量	313.86
MDL编号	MFCD00012537
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI	1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key	KFYRPLNVJVHZGT-UHFFFAOYSA-N
Gene Information	human ... SLC6A2(6530), SLC6A4(6532)

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H319 - H410
预防措施声明	P301 + P330 + P331 + P310 - P305 + P351 + P338
危险分类	Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

463103

Fluorochem

Amitriptyline Hydrochloride

95%

220元/1g; 242元/5g; 418元/10g; 968元/25g;

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基本信息

CAS Number	549-18-8
MDL Number	MFCD00012537
Melting Point	195℃

安全信息

图形或危害标志
危险性说明	H301: Toxic if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.