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关键词:       仅模糊查询
CAS: 54-85-3
分子式: C6H7N3O
分子量: 137.14
熔点: 170-174℃
中文名称: 
4-吡啶甲酰肼
异烟肼
雷米砜
利抓哉
雷米封
异烟酰肼
γ-吡啶甲酰肼
英文名称: 
inh
inh-burgthal
inizid
iscotin
isidrina
ismazide
isobicina
isocid
isocidene
isocotin
isolyn
isonerit
isonex
isoniazid
isoniazide
isonicazide
isonicid
isonico
isonicotan
isonicotil
isonicotinhydrazid
isonicotinoyl hydrazide
isonicotinoylhydrazine
isonicotinsaeurehydrazid
isonicotinyl hydrazide
isonicotinylhydrazine
isonide
4-Pyridinecarboxylic acid,hydrazide
isonidrin
isonikazid
isonilex
isonin
isonindon
isonirit
isoniton
isonizide
isotebe
isotebezid
isotinyl
isozid
isozide
isozyd
l 1945
laniazid
mybasan
neo-tizide
neoteben
neoxin
neumandin
nevin
niadrin
nicazide
nicetal
nicizina
niconyl
γ-Pyridincarbonsαure-hydrazid
nicotibina
nicozide
nidaton
nidrazid
nikozid
niplen
nitadon
niteban
nsc 9659
nydrazid
pelazid
iso-Nicotinic acid hydrazide
phthisen
Remifon
preparation 6424
Nydrazide
pycazide
pyrizidin
raumanon
retozide
rifamate
rimicid
rimifon
rimitsid
robisellin
roxifen
rp 5015
ru-ef-tb
sanohidrazina
sauterazid
stanozide
tb-phlogin
tb-razide
tb-vis
tebecid
tebenic
tebexin
tebilon
tebos
teebaconin
tekazin
tibazide
tibemid
tibinide
tibison
tibivis
tibizide
tibusan
tisin
tisiodrazida
tizide
tubazid
tubazide
tubeco
tubercid
tuberian
tubicon
tubomel
tyvid
unicozyde
usaf cb-2
vazadrine
vederon
zinadon
zonazide
iso-Nicotinyl hydrazide
Pyridine-4-carboxylic hydrazide
4-Pyridinecarboxylic acid, hydrazide
isonicotinic acid hydrazide
4-(hydrazinocarbonyl)pyridine
4-pyridinecarbonylhydrazine
4-pyridinecarboxylic acid hydrazide
4-pyridinecarboxylic hydrazide
4-pyridylcarbonylhydrazide
5015 rp
andrazide
antimicina
antituberkulosum
armazide
atcotibine
azuren
bp 5015
cedin
cedin (aerosol)
cemidon
chemiazid
chemidon
cotinazin
defonin
dibutin
diforin
dinacrin
ditubin
ebidene
eralon
ertuban
eutizon
evalon
fimalene
fsr 3
fsr-3
gink
hia
hidranizil
hidrasonil
hidrulta
hidrun
hycozid
hydrazid
hyozid
hyzyd
i.a.i.
ido-tebin
idrazide dell'acido isonicotinico
idrazil
in-73
inah
展开更多英文名
性质描述: 白色针状结晶。熔点174.4℃。在水中的溶解度:25℃,约14%;40℃,约26%。在乙醇中的溶解度:25℃,约2%。在沸乙醇中约10%。微溶于氯仿,实际上不溶于苯和醚。无气味。
生产方法: 由异烟酸与水合肼缩合而得。将异烟酸溶解于水合肼中,加入上批粗制母液,减压蒸馏至79-82℃(13.3-14.7kPa)为止。升温至129-130℃,反应3h。加入反应液一半量的母液稀释,加活性炭脱色,过滤。滤液冷却结晶,在10℃左右过滤,滤饼用粗制母液洗涤,得异烟肼粗品。然后经重结晶、活性炭脱色、过滤,干燥得成品。收率90%。
用途: 该品用作高效、低毒、价廉的抗结核病首选药物,也用作电镀添加剂和制药的中间体。导烟肼与甲醛亚硫酸氢钠缩合可制得异烟肼甲烷磺酸[13447-95-5]。与甲醛缩合成双异烟肼。这一缩合反应较溶易进行,将甲醛加入异烟肼水溶液,在65℃左右反应半小时即可。异烟肼与香草酸的缩合也在水溶液中进行,反应温度是95℃左右,生成异烟腙。这些异烟肼衍生物都是抗结核药物。异烟肼类以异烟肼的作用最好,异烟腙对结核菌的作用较异烟肼弱,但对神经系统及肝脏的毒性较异烟肼轻。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
I811712MACKLIN异烟肼99%44元/25g;   100元/100g;   365元/500g;   1499元/2.5kg;   展开
储存:2~8°C,干燥,密封
状态:白色到灰白色粉末
I811711MACKLIN异烟肼98%34元/25g;   86元/100g;   323元/500g;   1485元/2.5kg;   展开
储存:2~8°C,干燥,密封
状态:白色到灰白色粉末
I794569MACKLIN异烟肼10mM in DMSO450元/1ml;   展开
储存:-20°C
I0138TCIIsonicotinic Acid Hydrazide>98.0%(T)(HPLC)145元/25G;   245元/100G;   990元/500G;   展开

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C6H7N3O = 137.14
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气
Reaxys-RN119374
PubChem物质ID87571526
SDBS (AIST Spectral DB)1853
Merck Index (14)5186
MDL编号MFCD00006426

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %
Solubility in Wateralmost transparency
Melting point170.0 to 173.0 ℃

物性(参考值)

熔点172 ℃

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H371 : 可能损害器官。
H373 : 长期或反复接触可能损害器官。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P260 : 不要吸入粉尘/ 烟/ 气体/ 烟雾/ 蒸气/ 喷雾。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P308+P311 : 如接触到或有疑虑:呼叫急救中心/医生。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#NS1751850
225949J&KIsonicotinic Acid Hydrazide99%87元/25G;   195元/100G;   776元/500G;   展开

基本信息

分子式C6H7N3O
分子量137.14
熔点171-173
MDL编码MFCD00006426
Beilstein119374
Merck14,5186
EINECS 编号200-214-6

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H316
防范说明P280
P305+P351+P338
WGK3
RTECSNS1751850
TSCA
A10583Alfa AesarIsonicotinic Acid Hydrazide98+%197元/50g;   374元/100g;   1289元/500g;   2430元/1000g;   展开

应用
Used for fluorescent HPLC detection of delta 4-3-ketosteroids

基本信息

MDL
MFCD00006426

EINECS
200-214-6

分子式
C6H7N3O

分子量
137.14

熔点
169-174°

灵敏度
Air Sensitive. Store under Argon. Ambient temperatures.

形态
Powder

Beilstein
119374

Merck
14,5186

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H315-H319-H335
Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
26-36/37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
NS1751850

TSCA

C12260Alfa AesarIsonicotinic Acid Hydrazide99%537元/5g;   806元/100g;   3230元/500g;   展开

基本信息

Ref#
12260

MDL
6426

分子式
C6 H7 N3 O

分子量
137.14

形态
White powder

1349706USPIsoniazidUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

针对结核菌的抗生素,抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性,在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C6H7N3O
分子量137.14
Beilstein119374
MDL编号MFCD00006426
PubChem化学物质编号329750199
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp171-173 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringNNC(=O)c1ccncc1
InChI1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChI keyQRXWMOHMRWLFEY-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315
预防措施声明P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313
危险分类Acute Tox. 4 Oral - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
I0500000IsoniazidEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

针对结核菌的抗生素,抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性,在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C6H7N3O
分子量137.14
Beilstein119374
MDL编号MFCD00006426
PubChem化学物质编号329815311
NACRESNA.24

产品性质

等级pharmaceutical primary standard
agencyEP Reference Standard
manufacturer/tradenameEDQM
mp171-173 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringNNC(=O)c1ccncc1
InChI1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChI keyQRXWMOHMRWLFEY-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315
预防措施声明P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313
危险分类Acute Tox. 4 Oral - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
I3377SupelcoIsoniazidanalytical standard, ≥99% (TLC)262.14元/5 G;   1138.64元/50 G;   2259.77元/250 G;   展开

产品说明

一般描述

化学结构式:吡啶
异烟肼是一类具有抗分枝杆菌活性的药物。用于结核病的治疗。

应用

参考产品的检验报告,了解更多关于合适仪器技术的信息。联系技术服务部寻求进一步支持。

包装

5, 50, 250 g in poly bottle

生化/生理作用

针对结核菌的抗生素,抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性,在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。

基本信息

经验(实验)分子式C6H7N3O
分子量137.14
Beilstein119374
EC 号200-214-6
MDL编号MFCD00006426
PubChem化学物质编号329815370
NACRESNA.24

产品性质

质量水平100
等级analytical standard
测定≥99% (TLC)
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp171-173 ℃ (lit.)
荧光λex 360 nm; λem 450 nm (thiol adduct)
抗生素抗菌谱mycobacteria
application(s)forensics and toxicology
pharmaceutical (small molecule)
格式neat
SMILES stringNNC(=O)c1ccncc1
InChI1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChI keyQRXWMOHMRWLFEY-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315
预防措施声明P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313
危险分类Acute Tox. 4 Oral - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
V900688SupelcoIsoniazidVetec, reagent grade, 98%251.3元/100 G;   1055.78元/500 G;   展开

产品说明

包装

100, 500 g in poly bottle

生化/生理作用

针对结核菌的抗生素,抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性,在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

经验(实验)分子式C6H7N3O
分子量137.14
Beilstein119374
EC 号200-214-6
MDL编号MFCD00006426
PubChem化学物质编号329830060

产品性质

等级reagent grade
产品线Vetec
测定98%
mp171-173 ℃ (lit.)
格式neat
SMILES stringNNC(=O)c1ccncc1
InChI1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChI keyQRXWMOHMRWLFEY-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315
预防措施声明P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313
危险分类Acute Tox. 4 Oral - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
PHR1932SupelcoIsoniazidPharmaceutical Secondary Standard; Certified Reference Material2391.32元/500 MG;   展开

产品说明

一般描述

药物二级标准品CRM,为制药行业QC实验室及生产质量控制和研发,提供了一种方便、高性价比且符合相关法规的替代方案。

生化/生理作用

针对结核菌的抗生素,抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性,在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。

分析说明

这些二级标准品可溯源到USP、EP和BP一级标准品。

其他说明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

欲查看此物质的分析证书样本,请在下面的对话框中输入 LRAC3171。这只是一个示例证书,可能与您收到的批次不符。

基本信息

经验(实验)分子式C6H7N3O
分子量137.14
Beilstein119374
EC 号200-214-6
MDL编号MFCD00006426

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
形式powder
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
mp171-173 ℃ (lit.)
application(s)pharmaceutical
药典可追溯性traceable to BP 1083
traceable to PhEur I0500000
traceable to USP 1349706
储存温度2-8℃
SMILES stringNNC(=O)c1ccncc1
InChI1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChI keyQRXWMOHMRWLFEY-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315
预防措施声明P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313
危险分类Acute Tox. 4 Oral - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
BP1083IsoniazidBritish Pharmacopoeia (BP) Reference Standard2290.11元/100 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

针对结核菌的抗生素,抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性,在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C6H7N3O
分子量137.14
Beilstein119374
MDL编号MFCD00006426

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
mp171-173 ℃ (lit.)
格式neat
储存温度2-8℃
SMILES stringNNC(=O)c1ccncc1
InChI1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChI keyQRXWMOHMRWLFEY-UHFFFAOYSA-N
236758FluorochemIsonicotinohydrazide95%660元/100g;   7876元/1kg;   19690元/5kg;   展开

基本信息

CAS Number54-85-3
MDL NumberMFCD00006426

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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