CAS 54-77-3; 1,1-dimethyl-4-phenyl-piperaziniu iodide

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CAS:

54-77-3

分子式:

C12H19IN2

分子量:

318.20

熔点:

234-238℃

英文名称:

1,1-dimethyl-4-phenyl-piperaziniu iodide

1,1-dimethyl-4-phenylpiperazine iodide

1,1-dimethyl-4-phenylpiperazinium iodide

dmpp

dmpp iodide

1-Methyl-4-phenylpiperazinium 1-Methiodide

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

D865996

MACKLIN

1,1-二甲基-4-苯基碘化哌嗪鎓

98%

277元/200mg;

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储存：-20°C, 干燥
状态：白色-略淡黄色晶体-粉末

D5891

Sigma-Aldrich

1,1-Dimethyl-4-phenylpiperazinium iodide

≥98% (TLC or titration)

655.94元/1 G; 3557.45元/10 G;

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产品说明

应用

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:

to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon

包装

1, 10 g in glass bottle

生化/生理作用

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₂H₁₉IN₂
分子量	318.20
Beilstein	3746109
EC 号	200-213-0
MDL编号	MFCD00011976
PubChem化学物质编号	24277832
NACRES	NA.77

产品性质

质量水平	200
测定	≥98% (TLC or titration)
mp	234-238 ℃ (lit.)
溶解性	H₂O: 21 mg/mL
储存温度	−20℃
SMILES string	[I-].C[N+]1(C)CCN(CC1)c2ccccc2
InChI	1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1
InChI key	XFZJGFIKQCCLGK-UHFFFAOYSA-M
Gene Information	human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143) rat ... Chrna2(170945), Chrna3(25101), Chrna4(25590), Chrnb2(54239), Chrnb4(25103)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

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