| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| A793937 | MACKLIN | 氨基蝶呤 | 10mM in DMSO | 480元/1ml; | 展开 |
|
| A800526 | MACKLIN | 氨基蝶呤 | 98% | 210元/10mg; 695元/50mg; | 展开 |
|
| A0410 | TCI | Aminopterin | >97.0%(T)(HPLC) | 580元/25MG; 1590元/100MG; | 展开 |
基本信息 | 纯度/分析方法 | >97.0%(T)(HPLC) | | 分子式/分子量 | C19H20N8O5 = 440.42 | | 外观与形状(20℃) | 固体 | | 储存温度 | 0-10℃ | | 储存在惰性气体下 | 存放于惰性气体之中 | | 应避免的情况 | 空气,加热 | | 包装和容器 | 25MG-带有塑料内管的玻璃瓶 (查看图片) | | Reaxys-RN | 69045 | | PubChem物质ID | 125308158 | | Merck Index (14) | 472 | | MDL编号 | MFCD00036692 |
技术规格 | Appearance | White to Amber powder to crystal | | Purity(HPLC) | min. 97.0 area% | | Purity(Neutralization titration) | min. 97.0 %(calcd.on anh.substance) | | Specific rotation [a]20/D | +18.0 to +22.0 deg(C=1、0.1mol/LNaOH sol.)(calcd.on anh.substance) | | Water | 3.0 to 10.0 % |
物性(参考值) | 熔点 | 222 ℃(dec.) | | 比旋光度 [α]D | 20° (C=1,0.1mol/L NaOH) |
安全信息 | 图形或危害标志 |   | | 信号词 | 危险 | | 危险性说明 | H300 : 吞咽致命。
H360 : 可能对生育能力或胎儿造成伤害。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑：求医/就诊。
P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。
|
相关法规 运输信息 | UN编号 | UN2811 | | 类别 | 6.1 | | 包装类别 | I | | 监管条件代码(*) | |
|
| Y11064 | Alfa Aesar | Aminopterin | | 1559元/25mg; 3804元/100mg; 12183元/500mg; | 展开 |
|
| SBR00016 | Sigma-Aldrich | Aminopterin Ready Made Solution | 50 mg/mL in DMSO | 4982.26元/1 ML; | 展开 |
产品说明 生化/生理作用 Aminopterin is a synthetic derivative of pterin. It is used as a folic acid antagonist. It competitively inhibits dihydrofolate reductase (DHFR) and blocks tetrahydrofolate synthesis. This inhibition blocks DNA, RNA and protein synthesis.
Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.
Aminopterin was first administered for cancer therapy, as a drug targeting metabolism, specifically in pediatric leukemia. Later on it was demonstrated to be more potent yet more toxic than methotrexate. 基本信息 | 经验(实验)分子式 | C19H20N8O5 | | 分子量 | 440.41 | | MDL编号 | MFCD00036692 |
产品性质 | 测定 | ≥85% | | 质量水平 | 200 | | 形式 | liquid | | 储存条件 | protect from light | | 浓度 | 50 mg/mL in DMSO | | 溶解性 | DMSO: 50 mg/mL | | 运输 | dry ice | | 储存温度 | −20℃ | | SMILES string | OC(CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=NC3=C(N)N=C(N)N=C3N=C2)C=C1)=O)=O | | InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27) | | InChI key | TVZGACDUOSZQKY-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 - H360 | | 预防措施声明 | P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313 | | 危险分类 | Acute Tox. 3 Oral - Repr. 1B | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | 188.6 °F | | 闪点(C) | 87 ℃ |
|
| A1784 | Sigma-Aldrich | Aminopterin | powder | 4011.08元/50 MG; 6387.31元/100 MG; 32097.4元/1 G; | 展开 |
产品说明 包装 1 g in glass bottle
50 mg in glass bottle 生化/生理作用 叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内，它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物，该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。 特点和优势 这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。 联系 比甲氨喋呤更有效，但毒性也更强。 基本信息 | 经验(实验)分子式 | C19H20N8O5 | | 分子量 | 440.41 | | Beilstein | 69045 | | EC 号 | 200-209-9 | | PubChem化学物质编号 | 24278186 | | NACRES | NA.77 |
产品性质 | 质量水平 | 200 | | 生物来源 | synthetic (organic) | | 测定 | ≥97% (TLC) | | 形式 | powder | | 颜色 | yellow | | mp | 225 ℃ | | 溶解性 | 2 M NaOH: 50 mg/mL (Solutions may be stored for 1-2 days at 4℃.)
DMSO: soluble (Solutions may be stored for 1-2 days at 4℃.) | | ε (extinction coefficient) | 24,500 at 282 nm in 0.1 M NaOH at 1 M
25,700 at 261 nm in 0.1 M NaOH at 1 M
8,100 at 373 nm in 0.1 M NaOH at 1 M | | 储存温度 | −20℃ | | SMILES string | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 | | InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1 | | InChI key | TVZGACDUOSZQKY-LBPRGKRZSA-N | | Gene Information | human ... FPGS(2356)
mouse ... Fpgs(14287) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H300 - H360FD | | 预防措施声明 | P201 - P202 - P264 - P270 - P280 - P301 + P310 | | 危险分类 | Acute Tox. 1 Oral - Repr. 1B | | 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|
| A5159 | Sigma-Aldrich | Aminopterin | Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma | 970.67元/10 VIALS; | 展开 |
产品说明 应用 用于杂交瘤细胞培养应用的氨基蝶呤浓缩物添加剂。 生化/生理作用 叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内，它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物，该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。 联系 比甲氨喋呤更有效，但毒性也更强。 重悬 10mL 无菌细胞培养基可复原一小瓶本品。储备液足以制备 500mL 培养基。最终工作浓度：0.4μM 氨基蝶呤。 其他说明 Scripps Center for Metabolomics(斯克里普斯代谢组学中心)独立生成的串联质谱数据，可以PDF格式查看或下载。 A5159.pdf 斯克里普斯代谢组学METLIN代谢物数据库里有经过测试的代谢物的详细信息。更多信息请见sigma.com/metlin。 法律信息 Hybri-Max is a trademark of sigma-aldrich Co. LLC 基本信息 | 经验(实验)分子式 | C19H20N8O5 | | 分子量 | 440.41 | | Beilstein | 69045 | | EC 号 | 200-209-9 | | PubChem化学物质编号 | 24890950 | | NACRES | NA.75 |
产品性质 | 质量水平 | 200 | | 生物来源 | synthetic | | 等级 | Hybri-Max™ | | 无菌性 | γ-irradiated | | 产品线 | BioXtra | | 形式 | lyophilized powder | | 浓度 | 50 × | | technique(s) | cell culture | hybridoma: suitable | | 杂质 | endotoxin, tested | | 溶解性 | 10 mL/vial, clear, red (in TC Medium) | | ε (extinction coefficient) | 24,500 at 282 nm in 0.1 M NaOH at 1 M
25,700 at 261 nm in 0.1 M NaOH at 1 M
8,100 at 373 nm in 0.1 M NaOH at 1 M | | web metadata keyword.default | sigma-aldrich A5159, Aminopterin Hybri-Max™,γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid, folic acid analogue, DHFR inhibitor, antifolate, selection agent, GPT selection reagent | | 运输 | dry ice | | 储存温度 | −20℃ | | SMILES string | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 | | InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1 | | InChI key | TVZGACDUOSZQKY-LBPRGKRZSA-N | | Gene Information | human ... FPGS(2356)
mouse ... Fpgs(14287) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H300 - H315 - H319 - H341 - H360FD | | 预防措施声明 | P202 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 1 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 | | 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|
| A3411 | Sigma-Aldrich | Aminopterin | powder, BioReagent, suitable for cell culture | 1028.3元/10 MG; 1945.86元/25 MG; 6507.67元/100 MG; | 展开 |
产品说明 应用 氨基蝶呤已被用于生产抗神经颗粒蛋白抗体。 生化/生理作用 研究发现氨基蝶呤在小鼠模型中抑制生长、胚胎形成并具有毒性作用。它起堕胎药的作用。现已确知氨基蝶呤可减轻儿童急性白血病的影响。
叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内，它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物，该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。 联系 比甲氨喋呤更有效，但毒性也更强。 基本信息 | 经验(实验)分子式 | C19H20N8O5 | | 分子量 | 440.41 | | Beilstein | 69045 | | EC 号 | 200-209-9 | | PubChem化学物质编号 | 24890768 | | NACRES | NA.75 |
产品性质 | 质量水平 | 200 | | 生物来源 | synthetic (organic) | | 产品线 | BioReagent | | 测定 | ≥97% | | 形式 | powder | | technique(s) | cell culture | mammalian: suitable | | 颜色 | yellow | | 溶解性 | 2 M NaOH: 50 mg/mL
DMSO: soluble | | ε (extinction coefficient) | 24,500 at 282 nm in 0.1 M NaOH at 1 M
25,700 at 261 nm in 0.1 M NaOH at 1 M
8,100 at 373 nm in 0.1 M NaOH at 1 M | | web metadata keyword.default | sigma-aldrich A3411, Aminopterin powder, BioReagent, suitable for cell culture, 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid, folic acid analogue, DHFR inhibitor, antifolate, hybridoma selection agent | | 运输 | dry ice | | 储存温度 | −20℃ | | SMILES string | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 | | InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1 | | InChI key | TVZGACDUOSZQKY-LBPRGKRZSA-N | | Gene Information | human ... FPGS(2356)
mouse ... Fpgs(14287) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H300 - H360FD | | 预防措施声明 | P201 - P202 - P264 - P270 - P280 - P301 + P310 | | 危险分类 | Acute Tox. 1 Oral - Repr. 1B | | 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|
| 1414025 | USP | Methotrexate Related Compound B | United States Pharmacopeia (USP) Reference Standard | 12328.4元/75 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内，它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物，该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。 联系 比甲氨喋呤更有效，但毒性也更强。 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here.
Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C19H20N8O5 | | 分子量 | 440.41 | | Beilstein | 69045 | | PubChem化学物质编号 | 329750411 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | ε (extinction coefficient) | 24,500 at 282 nm in 0.1 M NaOH at 1 M
25,700 at 261 nm in 0.1 M NaOH at 1 M
8,100 at 373 nm in 0.1 M NaOH at 1 M | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 | | InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1 | | InChI key | TVZGACDUOSZQKY-LBPRGKRZSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H300 - H360 | | 预防措施声明 | P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313 | | 危险分类 | Acute Tox. 2 Oral - Repr. 1B | | 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
m.cnreagent.com