基本信息

技术规格

物性(参考值)

基本信息

安全信息

图形或危害标志
提示语	Danger
危险说明	H318 H411
防范说明	P273 P280 P305+P351+P338
UN号码	3077
危险分类	9
包装等级	III
WGK	3

产品说明

一般描述

紫檀芪(反式-3,5-二甲氧基-4-羟基芪)抗氧化剂是白藜芦醇的类似物，存在于蓝莓、树木和几种葡萄中。

应用

紫檀芪已用于：

• 研究其抗氧化应激活性以及在核转录因子E2相关因子2(Nrf2)-抗氧化反应元件(ARE)信号转导通路中的调节作用
• 确定其对激素耐受性乳腺癌细胞雌激素受体α(ERα)转录激活的影响
• 通过MTT(3-[4,5-二甲基噻唑-2-基]-2,5二苯基四氮唑溴化物)活力检测法研究其对人表皮样癌细胞(A-431)中2-氯乙基乙基硫醚(CEES)的细胞毒性的影响。

包装

10 mg in glass bottle

生化/生理作用

紫檀芪对几种恶性肿瘤具有抗癌作用，因此可作为活性抗癌药物。在雌激素受体阳性和阴性乳腺癌细胞系中，它可激活细胞凋亡并抑制细胞活性。
抗氧化、抗增殖、细胞凋亡诱导、抗高血糖、抗糖尿病。

注意

空气敏感性

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H318 - H411
预防措施声明	P273 - P280 - P305 + P351 + P338 + P310
危险分类	Aquatic Chronic 2 - Eye Dam. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化/生理作用

抗氧化、抗增殖、细胞凋亡诱导、抗高血糖、抗糖尿病。

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H318 - H411
预防措施声明	P273 - P280 - P305 + P351 + P338 + P310
危险分类	Aquatic Chronic 2 - Eye Dam. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

一般描述

A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox (Cat. No. 64847). Moderately inhibits COX-1 & COX-2 activities (IC₅₀ = 19.8 µM & 83.9 µM, respectively) and induces apoptosis in HL60 cells (IC₅₀ = 70 µM). Also prevents DMBA-induced pre-neoplastic lesions (ED₅₀ = 4.8 µM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.
A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, antiproliferative, and hypoglycemic properties. Moderately inhibits COX-1 and -2 activities (IC₅₀ = 19.8 µM and 83.9 µM) respectively, induces apoptosis in HL60 cells (IC₅₀ = 70 µM), prevents DMBA-induced preneoplastic lesions (ED₅₀ = 4.8 µM) and decreases plasma glucose level in streptozotocin-induced diabetic rats comparable to that of Metformin.

包装

10 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 19.8 µM, 83.9 µM against COX-1 and -2 activities, respectively; 70 µM for inducing apoptosis in HL60 cells; ED50 = 4.8 µM for preventing DMBA-induced preneoplastic lesions
Primary Target
COX-1 and COX-2 activities
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Roberti, M., et al. 2003. J. Med. Chem.46, 3546.
Rimando, A.M., et al. 2002. J. Agric. Food Chem.50, 3453.
Manickam, M., et al. 1997. J. Nat. Prod.60, 609.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H318 - H411
预防措施声明	P273 - P280 - P305 + P351 + P338 - P391 - P501
危险分类	Aquatic Chronic 2 - Eye Dam. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

基本信息

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .