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CAS: 524-95-8
分子式: C14H16BNO
分子量: 225.09
熔点: 190-194℃
中文名称: 
二苯基硼酸乙醇胺
2-氨基乙基联苯基硼酸酯
二苯基酸
英文名称: 
2-Aminoethyl diphenylborinate
2-Aminoethyl diphenyl borate
Diphenylboric acid ethanolamine complex
(2-Aminoethoxy)diphenylborane
o-(2-aminoethyl)diphenyl-borinic aci
2-aminoethoxydiphenylborane
b-(2-aminoethoxy)diphenylborane
diphenyl-borinic aci 2-aminoethyl ester
diphenylborinic acid 2-aminoethyl ester
推荐供应商
货号品牌产品名称规格包装、参考价格详情
A800496MACKLIN二苯基硼酸-2-氨基乙酯98%122元/1g;   390元/5g;   1469元/25g;   5034元/100g;   展开
储存:-20°C
状态:白色到黄色到米黄色或棕色结晶粉末
A797140MACKLIN二苯基硼酸-2-氨基乙酯10mM in DMSO383元/1ml;   展开
储存:-20°C
D0281TCI2-Aminoethyl Diphenylborinate>98.0%(T)(HPLC)1280元/10G;   2655元/25G;   展开

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C14H16BNO = 225.10
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况光,湿气 (分解)
Reaxys-RN2942273
PubChem物质ID87566979
SDBS (AIST Spectral DB)7335
MDL编号MFCD00014823

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %
Melting point189.0 to 194.0 ℃
Solubility in Methanolalmost transparency

物性(参考值)

熔点190 ℃
溶解性(可溶于)甲醇

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#ED6150000
A16606Alfa Aesar2-Aminoethyl Diphenylborinate98%700元/5g;   2392元/25g;   展开

应用
2-Aminoethyl diphenylborinate is used for the densitometric determination of flavonoids and TRP activator. It is also used to manipulate intracellular release of calcium ions and in preparation of apoptotic inducers. It serves as a reactant for preparation of apoptotic inducers and in membrane-permeable SOCE (store operated calcuym entry) inhibitor.

备注
Incompatible with strong oxidizing agents.

基本信息

MDL
MFCD00014823

EINECS
208-366-5

分子式
C14H16BNO

分子量
225.10

熔点
187-190°

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in ethanol and methanol.

Beilstein
2942273

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

RTECS
ED6150000

TSCA

C15542Alfa AesarDiphenylborinic Acid 2-Aminoethyl Ester98%1065元/5g;   1862元/10g;   3402元/25g;   展开

基本信息

Ref#
15542

MDL
14823

分子式
C14 H16 B N O

分子量
225.1

形态
Powder

D9754Sigma-Aldrich2-Aminoethyl Diphenylborinate97%360.06元/1 G;   719.29元/5 G;   1387.76元/10 G;   2140.5元/25 G;   展开

产品说明

应用

可用作以下反应试剂:

  • 制备细胞凋亡诱导剂
  • Orai3(ORAI钙释放-激活钙调节因子3)蛋白活化剂
  • 抑制大鼠背根神经节神经元通过瞬时受体电位2通道的Ca2+
  • 膜渗透SOCE(库调控钙入口)抑制剂

包装

1, 5, 10, 25 g in glass bottle

生化/生理作用

用于细胞内 IP3 诱导钙释放的膜渗透性调节剂。

基本信息

线性分子式(C6H5)2BOCH2CH2NH2
分子量225.09
Beilstein2942273
EC 号208-366-5
MDL编号MFCD00014823
PubChem化学物质编号57654145
NACRESNA.22

产品性质

质量水平200
测定97%
形式powder
储存温度−20℃
SMILES stringNCCOB(c1ccccc1)c2ccccc2
InChI1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChI keyBLZVCIGGICSWIG-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
100065Sigma-Aldrich2-APB-CAS 524-95-8-CalbiochemA cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.1078.01元/100 MG;   展开

产品说明

一般描述

Ins(1,4,5)P3诱导Ca2+释放的细胞渗透性调节剂。可抑制大鼠小脑微粒体中Ins(1,4,5)P3诱导的Ca2+释放(IC50 = 42 µM),且不会影响[3H]-Ins(1,4,5)P3 与其受体的结合。在肝细胞中,2-APB可通过一种可能涉及其与通道蛋白或相关调节蛋白结合的机制,来抑制Ca2+库通道。其对Ca2+从对精氨酸敏感的Ca2+库(由大鼠腿部骨骼肌和心脏中制备得到)中释放没有影响。
Ins(1,4,5)P3诱导Ca2+释放的细胞渗透性调节剂。可抑制大鼠小脑微粒体中Ins(1,4,5)P3诱导的Ca2+释放(IC50 = 42 µM),且不会影响[3H]-Ins(1,4,5)P3 与其受体的结合。其对Ca2+从对精氨酸敏感的Ca2+库(由大鼠腿部骨骼肌和心脏中制备得到)中释放没有影响。可抑制子宫收缩剂诱导的自发性收缩和相位收缩。也有报道其可抑制血管紧张素Ⅱ诱导的主动脉收缩。

包装

100 mg in Glass bottle
用惰性气体包装

生化/生理作用

产物不与ATP竞争。
靶标IC50:42 µM,抑制Ins(1,4,5)P3诱导的大鼠小脑微粒体制剂中Ca2+的释放
主要靶标
Ins(1,4,5)P3诱导的Ca2+释放
可逆:否
细胞可渗透性:具有

警告

毒性:标准处理(A)

重悬

溶解后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存2个月。

其他说明

Brooke, R. T., et al. 2004.Lab. Invest.84, 29.
Gregory, R.B., et al. 2001.Biochem.J.354, 285.
Ma, H.T., et al. 2001.J. Biol. Chem.276, 18888.
Ascher-Landsberg, S., et al. 1999.Biochem.Biophys.Res. Commun.264, 979.
Maruyama, T., et al. 1997.J. Biochem.122, 498.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C14H16BNO
分子量225.09
MDL编号MFCD00014823
NACRESNA.77

产品性质

质量水平100
测定≥97% (titration)
形式crystalline solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性DMSO: 20 mg/mL
95% ethanol: 25 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChI keyBLZVCIGGICSWIG-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
8.41636Sigma-Aldrich2-Aminoethyldiphenyl boratefor synthesis322.08元/500 MG;   468.71元/5 G;   展开

基本信息

经验(实验)分子式C14H16BNO
分子量225.09
MDL编号MFCD00014823
EC索引号208-366-5

产品性质

质量水平200
mp189-194 ℃
InChI1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChI keyBLZVCIGGICSWIG-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
047253Fluorochem2-Aminoethyl diphenyl borinate>98.0%(HPLC)(T)2442元/10g;   4972元/25g;   展开

基本信息

CAS Number524-95-8
MDL NumberMFCD00014823

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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