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CAS: 520-36-5
分子式: C15H10O5
分子量: 270.24
熔点: 352℃
中文名称: 
芹菜素
英文名称: 
4',5,7-trihydroxy-flavon
2-(p-hydroxyphenyl)-5,7-dihydroxychromone
4',5,7-trihydroxyflavaone
4',5,7-trihydroxyflavone
5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on
apigenin
apigenine
apigenol
c.i. natural yellow 1
chamomile
apigenin from parsley
展开更多英文名
推荐供应商
货号品牌产品名称规格包装、参考价格
A800499MACKLIN芹菜素分析对照品152元/20mg;   咨询
储存:-20°C
状态:黄色粉末
A828124MACKLIN芹菜素≥95% (HPLC)30元/1g;   89元/5g;   370元/25g;   1399元/100g;   咨询
储存:-20°C
A823203MACKLIN芹菜素≥97% (HPLC)32元/1g;   102元/5g;   400元/25g;   1578元/100g;   咨询
储存:-20°C
状态:黄色粉末或晶体
A800500MACKLIN芹菜素≥98.0% (HPLC)30元/25mg;   35元/100mg;   46元/500mg;   78元/1g;   160元/5g;   508元/25g;   1822元/100g;   咨询
储存:-20°C
状态:黄色到黄绿色粉末
A1514TCIApigenin>98.0%(HPLC)1400元/100MG;   咨询

基本信息

纯度/分析方法>98.0%(HPLC)
分子式/分子量C15H10O5 = 270.24
外观与形状(20℃)固体
Reaxys-RN262620
PubChem物质ID87562965
Merck Index (14)730
MDL编号MFCD00006831

技术规格

AppearanceLight yellow to Brown powder to crystal
Purity(HPLC)min. 98.0 area%

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#LK9276000
470737J&KApigenin98%60元/5MG;   63元/25MG;   66元/100MG;   70元/500MG;   咨询

基本信息

分子式C15H10O5
分子量270.24
熔点>300
MDL编码MFCD00006831
Beilstein262620
Merck14,730
EINECS 编号208-292-3
存储条件Freezer -20℃

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
RTECSLK9276000
952027J&KApigenin来源于芹菜, 有效含量≥90%, 可溯源至中检院标准品228元/20MG;   咨询

基本信息

分子式C15H10O5
分子量270.24
MDL编码MFCD00006831
L15041Alfa Aesar4',5,7-Trihydroxyflavone97%1384元/25mg;   3853元/100mg;   咨询

应用
4',5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with and strong oxidizing agents.

基本信息

MDL
MFCD00006831

EINECS
208-292-3

分子式
C15H10O5

分子量
270.24

熔点
ca 315° dec.

灵敏度
Keep Cold.

形态
Powder

溶解性
Soluble in dimethyl sulfoxide (27 mg/ml) or 1M potassium hydroxide (50mg/ml).

Beilstein
262620

Merck
14,730

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

RTECS
LK9276000

TSCA

178278Sigma-AldrichApigenin-CAS 520-36-5-CalbiochemInduces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM).773.29元/5 MG;   咨询

产品说明

一般描述

A plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G2/M arrest and to induce morphological differentiation.
Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation.

包装

5 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Reversible: no
Primary Target
MAP kinase
Cell permeable: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.

其他说明

Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun.212, 767.
Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
Kuo, M.L., et al. 1994. Cancer Lett.87, 91.
Sato, F., et al. 1994. Biochem. Biophys. Res. Commun.204, 578.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C15H10O5
分子量270.24
MDL编号MFCD00006831

产品性质

质量水平100
测定≥98% (HPLC)
形式crystalline solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 yellow
溶解性hot ethanol: 1 mg/mL
DMSO: 10 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI keyKZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
SMB00702Sigma-AldrichApigenin≥97% (TLC), from citrus559.88元/5 MG;   1652.94元/25 MG;   5078.82元/100 MG;   咨询

产品说明

一般描述

Apigenin (ApI) is also called as 5,7,4′-trihydroxyflavone. It is a natural compound, found in several fruits and herbs, like, oranges, onions and parsley.

包装

5 mg in glass bottle
25, 100 mg in poly bottle

生化/生理作用

Apigenin (ApI) blocks the development of thyroid cancer cells by attenuating epidermal growth factor receptor (EGF-R) tyrosine phosphorylation and phosphorylation of ERK mitogen-activated protein (MAP) kinase. Apigenin participates in the modulation of different signaling cascades. It possesses several functions such as, antiapoptosis, anti-inflammation, anticancer, antibacterial and antioxidant effects.
一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein262620
EC 号208-292-3
MDL编号MFCD00006831
NACRESNA.79

产品性质

质量水平200
测定≥97% (TLC)
形式powder
mp>300 ℃ (lit.)
溶解性DMSO: 27 mg/mL
1 M KOH: 50 mg/mL
储存温度−20℃
SMILES stringOc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI keyKZNIFHPLKGYRTM-UHFFFAOYSA-N
Gene Informationhuman ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)
mouse ... Hexa(15211)
rat ... Adora1(29290), Adora2a(25369), IL4(287287), Tnf(24835)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
10798Sigma-AldrichApigenin≥95.0% (HPLC)1430.82元/25 MG;   3507.18元/100 MG;   咨询

产品说明

一般描述

Apigenin is a 270 Da flavonoid, which belongs to the flavone group of glycosides. It is synthesized by a wide variety of plants including cereals, grains, tea and oranges.

应用

芹菜素已被用作校准标准,结合高效液相色谱(HPLC)和二极管阵列检测(DAD)对山柳菊、枯柏树进行定量。它已用于研究对人肾上腺皮质H295R细胞激素分泌的影响。

生化/生理作用

芹菜素是一种二级药物,肠渗透性强。它具有抗氧化、抗炎和抗肿瘤的功能。它是分化簇38 (CD30)核苷酸腺嘌呤二核苷酸(NAD+)核苷酶的有效抑制剂,可用于抑制CD30介导的代谢综合征。
一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

其他说明

人雌激素合成酶抑制剂

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein262620
EC 号208-292-3
MDL编号MFCD00006831
PubChem化学物质编号57646817
NACRESNA.77

产品性质

质量水平100
测定≥95.0% (HPLC)
杂质~2% water
mp>300 ℃ (lit.)
储存温度−20℃
SMILES stringOc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI keyKZNIFHPLKGYRTM-UHFFFAOYSA-N
Gene Informationhuman ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)
mouse ... Hexa(15211)
rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
42251SupelcoApigeninanalytical standard4040.52元/10 MG;   咨询

产品说明

一般描述

黄酮类化合物属于多酚类化合物。在抑制肿瘤生长和化学预防等生物活性中起关键作用。芹菜素是一种植物类黄酮,多用于抑制鸟氨酸脱羧酶活性和皮肤肿瘤。

应用

LC-ESI-MS/MS 可作为内标物,用于测定大鼠血液和尿液中的飞燕草苷及其代谢产物。
有关合适仪器技术的更多信息,请参考产品分析证书。如需进一步支持,请联系技术服务。

生化/生理作用

一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein262620
EC 号208-292-3
MDL编号MFCD00006831
PubChem化学物质编号329756029
NACRESNA.24

产品性质

质量水平100
等级analytical standard
测定≥99% (HPLC)
保质期limited shelf life, expiry date on the label
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp>300 ℃ (lit.)
application(s)food and beverages
格式neat
储存温度2-8℃
SMILES stringOc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI keyKZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
PHR2198SupelcoApigeninPharmaceutical Secondary Standard; Certified Reference Material1909.73元/75 MG;   咨询

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC2233 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein262620
MDL编号MFCD00006831

产品性质

等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 75 mg
mp>300 ℃ (lit.)
格式neat
药典可追溯性traceable to USP 1040683
储存温度-10 to -25℃
SMILES stringOc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI keyKZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHL89159Apigeninphyproof® Reference Substance3997.36元/25 MG;   咨询

产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化/生理作用

一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein262620
MDL编号MFCD00006831

产品性质

等级primary reference standard
产品线phyproof® Reference Substance
测定≥95.0% (HPLC)
形式powder
manufacturer/tradenamePhytoLab
mp>300 ℃ (lit.)
SMILES stringOc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI keyKZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
1040683USPApigeninUnited States Pharmacopeia (USP) Reference Standard3889.96元/30 MG;   咨询

产品说明

一般描述

Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor.

应用

It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats.

生化/生理作用

一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein262620
MDL编号MFCD00006831
PubChem化学物质编号329749048
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp>300 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度−20℃
SMILES stringOc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI keyKZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
01760595Apigeninprimary reference standard5844.83元/10 MG;   咨询

产品说明

一般描述

Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor.
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

应用

It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats.

生化/生理作用

一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

基本信息

经验(实验)分子式C15H10O5
分子量270.24
Beilstein262620
EC 号208-292-3
MDL编号MFCD00006831
PubChem化学物质编号329747355
NACRESNA.24

产品性质

等级primary reference standard
保质期limited shelf life, expiry date on the label
manufacturer/tradenameHWI
mp>300 ℃ (lit.)
application(s)food and beverages
SMILES stringOc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI keyKZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
M01289Fluorochem4,5,7-Trihydroxyflavone>95%242元/1g;   726元/5g;   1144元/10g;   2420元/25g;   咨询

基本信息

CAS Number520-36-5
MDL NumberMFCD00006831
Melting Point345-350℃

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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