| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| A800499 | MACKLIN | 芹菜素 | 分析对照品 | 152元/20mg; | 咨询 |
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| A828124 | MACKLIN | 芹菜素 | ≥95% (HPLC) | 30元/1g; 89元/5g; 370元/25g; 1399元/100g; | 咨询 |
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| A823203 | MACKLIN | 芹菜素 | ≥97% (HPLC) | 32元/1g; 102元/5g; 400元/25g; 1578元/100g; | 咨询 |
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| A800500 | MACKLIN | 芹菜素 | ≥98.0% (HPLC) | 30元/25mg; 35元/100mg; 46元/500mg; 78元/1g; 160元/5g; 508元/25g; 1822元/100g; | 咨询 |
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| A1514 | TCI | Apigenin | >98.0%(HPLC) | 1400元/100MG; | 咨询 |
基本信息 | 纯度/分析方法 | >98.0%(HPLC) | | 分子式/分子量 | C15H10O5 = 270.24 | | 外观与形状(20℃) | 固体 | | Reaxys-RN | 262620 | | PubChem物质ID | 87562965 | | Merck Index (14) | 730 | | MDL编号 | MFCD00006831 |
技术规格 | Appearance | Light yellow to Brown powder to crystal | | Purity(HPLC) | min. 98.0 area% |
安全信息 | 图形或危害标志 |  | | 信号词 | 警告 | | 危险性说明 | H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
| | 防范说明 | P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染:用水充分清洗。 P337 + P313 : 如仍觉眼刺激:求医/就诊。 P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激:求医/就诊。
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相关法规 |
| 470737 | J&K | Apigenin | 98% | 60元/5MG; 63元/25MG; 66元/100MG; 70元/500MG; | 咨询 |
基本信息 | 分子式 | C15H10O5 | | 分子量 | 270.24 | | 熔点 | >300 | | MDL编码 | MFCD00006831 | | Beilstein | 262620 | | Merck | 14,730 | | EINECS 编号 | 208-292-3 | | 存储条件 | Freezer -20℃ |
安全信息 | 图形或危害标志 |  | | 提示语 | Warning | | 危险说明 | H315 H319 H335 | | 防范说明 | P261 P305+P351+P338 | | WGK | 3 | | RTECS | LK9276000 |
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| 952027 | J&K | Apigenin | 来源于芹菜, 有效含量≥90%, 可溯源至中检院标准品 | 228元/20MG; | 咨询 |
基本信息 | 分子式 | C15H10O5 | | 分子量 | 270.24 | | MDL编码 | MFCD00006831 |
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| L15041 | Alfa Aesar | 4',5,7-Trihydroxyflavone | 97% | 1384元/25mg; 3853元/100mg; | 咨询 |
应用 4',5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication. 备注 Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with and strong oxidizing agents. 基本信息 MDL MFCD00006831 EINECS 208-292-3 分子式 C15H10O5 分子量 270.24 熔点 ca 315° dec. 灵敏度 Keep Cold. 形态 Powder 溶解性 Soluble in dimethyl sulfoxide (27 mg/ml) or 1M potassium hydroxide (50mg/ml). Beilstein 262620 Merck 14,730 GHS危害和防范说明 GHS符号
 Hazard Statements H315-H319-H335 Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation. Precautionary Statements P261-P280a-P305+P351+P338-P304+P340-P405-P501a Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations. 安全信息 危险类别 36/37/38 Irritating to eyes, respiratory system and skin. 安全等级 26-37 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. RTECS LK9276000 TSCA 否 |
| 178278 | Sigma-Aldrich | Apigenin-CAS 520-36-5-Calbiochem | Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). | 773.29元/5 MG; | 咨询 |
产品说明 一般描述 A plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G2/M arrest and to induce morphological differentiation. Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. 包装 5 mg in Plastic ampoule 生化/生理作用 Product does not compete with ATP. Reversible: no Primary Target MAP kinase Cell permeable: no 警告 Toxicity: Irritant (B) 重悬 Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C. 其他说明 Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun.212, 767. Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325. Kuo, M.L., et al. 1994. Cancer Lett.87, 91. Sato, F., et al. 1994. Biochem. Biophys. Res. Commun.204, 578. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 | | MDL编号 | MFCD00006831 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | crystalline solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze | | 颜色 | yellow | | 溶解性 | hot ethanol: 1 mg/mL DMSO: 10 mg/mL | | 运输 | ambient | | 储存温度 | 2-8℃ | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H | | InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| SMB00702 | Sigma-Aldrich | Apigenin | ≥97% (TLC), from citrus | 559.88元/5 MG; 1652.94元/25 MG; 5078.82元/100 MG; | 咨询 |
产品说明 一般描述 Apigenin (ApI) is also called as 5,7,4′-trihydroxyflavone. It is a natural compound, found in several fruits and herbs, like, oranges, onions and parsley. 包装 5 mg in glass bottle 25, 100 mg in poly bottle 生化/生理作用 Apigenin (ApI) blocks the development of thyroid cancer cells by attenuating epidermal growth factor receptor (EGF-R) tyrosine phosphorylation and phosphorylation of ERK mitogen-activated protein (MAP) kinase. Apigenin participates in the modulation of different signaling cascades. It possesses several functions such as, antiapoptosis, anti-inflammation, anticancer, antibacterial and antioxidant effects. 一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 | | Beilstein | 262620 | | EC 号 | 208-292-3 | | MDL编号 | MFCD00006831 | | NACRES | NA.79 |
产品性质 | 质量水平 | 200 | | 测定 | ≥97% (TLC) | | 形式 | powder | | mp | >300 ℃ (lit.) | | 溶解性 | DMSO: 27 mg/mL 1 M KOH: 50 mg/mL | | 储存温度 | −20℃ | | SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H | | InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA-N | | Gene Information | human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931) mouse ... Hexa(15211) rat ... Adora1(29290), Adora2a(25369), IL4(287287), Tnf(24835) |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| 10798 | Sigma-Aldrich | Apigenin | ≥95.0% (HPLC) | 1430.82元/25 MG; 3507.18元/100 MG; | 咨询 |
产品说明 一般描述 Apigenin is a 270 Da flavonoid, which belongs to the flavone group of glycosides. It is synthesized by a wide variety of plants including cereals, grains, tea and oranges. 应用 芹菜素已被用作校准标准,结合高效液相色谱(HPLC)和二极管阵列检测(DAD)对山柳菊、枯柏树进行定量。它已用于研究对人肾上腺皮质H295R细胞激素分泌的影响。 生化/生理作用 芹菜素是一种二级药物,肠渗透性强。它具有抗氧化、抗炎和抗肿瘤的功能。它是分化簇38 (CD30)核苷酸腺嘌呤二核苷酸(NAD+)核苷酶的有效抑制剂,可用于抑制CD30介导的代谢综合征。 一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。 包装 无底玻璃瓶。内含物在插入的融合锥体内。 其他说明 人雌激素合成酶抑制剂 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 | | Beilstein | 262620 | | EC 号 | 208-292-3 | | MDL编号 | MFCD00006831 | | PubChem化学物质编号 | 57646817 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥95.0% (HPLC) | | 杂质 | ~2% water | | mp | >300 ℃ (lit.) | | 储存温度 | −20℃ | | SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H | | InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA-N | | Gene Information | human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931) mouse ... Hexa(15211) rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835) |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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| 42251 | Supelco | Apigenin | analytical standard | 4040.52元/10 MG; | 咨询 |
产品说明 一般描述 黄酮类化合物属于多酚类化合物。在抑制肿瘤生长和化学预防等生物活性中起关键作用。芹菜素是一种植物类黄酮,多用于抑制鸟氨酸脱羧酶活性和皮肤肿瘤。 应用 LC-ESI-MS/MS 可作为内标物,用于测定大鼠血液和尿液中的飞燕草苷及其代谢产物。 有关合适仪器技术的更多信息,请参考产品分析证书。如需进一步支持,请联系技术服务。 生化/生理作用 一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。 包装 无底玻璃瓶。内含物在插入的融合锥体内。 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 | | Beilstein | 262620 | | EC 号 | 208-292-3 | | MDL编号 | MFCD00006831 | | PubChem化学物质编号 | 329756029 | | NACRES | NA.24 |
产品性质 | 质量水平 | 100 | | 等级 | analytical standard | | 测定 | ≥99% (HPLC) | | 保质期 | limited shelf life, expiry date on the label | | technique(s) | HPLC: suitable gas chromatography (GC): suitable | | mp | >300 ℃ (lit.) | | application(s) | food and beverages | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H | | InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| PHR2198 | Supelco | Apigenin | Pharmaceutical Secondary Standard; Certified Reference Material | 1909.73元/75 MG; | 咨询 |
产品说明 一般描述 Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards 生化/生理作用 一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。 分析说明 These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. 其他说明 This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. 附注 To see an example of a Certificate of Analysis for this material enter LRAC2233 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 | | Beilstein | 262620 | | MDL编号 | MFCD00006831 |
产品性质 | 等级 | certified reference material pharmaceutical secondary standard | | CofA | current certificate can be downloaded | | 包装 | pkg of 75 mg | | mp | >300 ℃ (lit.) | | 格式 | neat | | 药典可追溯性 | traceable to USP 1040683 | | 储存温度 | -10 to -25℃ | | SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H | | InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| PHL89159 | | Apigenin | phyproof® Reference Substance | 3997.36元/25 MG; | 咨询 |
产品说明 一般描述 This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG 生化/生理作用 一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。 法律信息 phyproof is a registered trademark of PhytoLab GmbH & Co. KG 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 | | Beilstein | 262620 | | MDL编号 | MFCD00006831 |
产品性质 | 等级 | primary reference standard | | 产品线 | phyproof® Reference Substance | | 测定 | ≥95.0% (HPLC) | | 形式 | powder | | manufacturer/tradename | PhytoLab | | mp | >300 ℃ (lit.) | | SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H | | InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 |
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| 1040683 | USP | Apigenin | United States Pharmacopeia (USP) Reference Standard | 3889.96元/30 MG; | 咨询 |
产品说明 一般描述 Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor. 应用 It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats. 生化/生理作用 一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here. Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 | | Beilstein | 262620 | | MDL编号 | MFCD00006831 | | PubChem化学物质编号 | 329749048 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | mp | >300 ℃ (lit.) | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | −20℃ | | SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H | | InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| 01760595 | | Apigenin | primary reference standard | 5844.83元/10 MG; | 咨询 |
产品说明 一般描述 Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor. Produced and qualified by HWI pharma services GmbH. Exact content by quantitative NMR can be found on the certificate. 应用 It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats. 生化/生理作用 一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。 基本信息 | 经验(实验)分子式 | C15H10O5 | | 分子量 | 270.24 | | Beilstein | 262620 | | EC 号 | 208-292-3 | | MDL编号 | MFCD00006831 | | PubChem化学物质编号 | 329747355 | | NACRES | NA.24 |
产品性质 | 等级 | primary reference standard | | 保质期 | limited shelf life, expiry date on the label | | manufacturer/tradename | HWI | | mp | >300 ℃ (lit.) | | application(s) | food and beverages | | SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 | | InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H | | InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| M01289 | Fluorochem | 4,5,7-Trihydroxyflavone | >95% | 242元/1g; 726元/5g; 1144元/10g; 2420元/25g; | 咨询 |
基本信息 | CAS Number | 520-36-5 | | MDL Number | MFCD00006831 | | Melting Point | 345-350℃ |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .
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