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CAS: 52-67-5
分子式: C5H11NO2S
分子量: 149.21
熔点: 212℃
中文名称: 
D-青霉胺
β-巯基缬氨酸
青霉胺
英文名称: 
3-mercapto-d-valin
depamine
depen
dimethylcysteine
emtexate
mercaptyl
metalcaptase
pendramine
penicillamin
penicillamine
d-penicillamin
perdolat
reduced d-penicillamine
reduced penicillamine
trolovol
usan
d(-)-penicillamine
Cuprimin
Distamin
3,3-Dimethyl-D-cysteine
D-(-)-Penicillamine
D-beta,beta-Dimethylcysteine
D-beta-Mercaptovaline
d-valin
(d)-penicillamine
(S)-penicillamin
(S)-penicillamine
3-mercapto-d-valine
alpha-amino-beta-methyl-beta-mercaptobutyric acid
beta,beta-dimethylcysteine
beta-mercaptovaline
beta-thiovaline
cuprenil
cuprimine
d-3-mercaptovaline
d-mercaptovaline
d-penamine
d-penicillamine
展开更多英文名
性质描述: 白色细晶粉末。熔点198.5℃。易溶于水,微溶于乙醇,不溶于乙醚或氯仿。有特殊臭味,味苦。
生产方法: 由青霉素G钾盐水解而得。
用途: 该品为金属毒剂。其分子中的巯基和氨基能络合金属离子,生成水溶性络合物,从尿中排出。主要用于铜中毒,对铝、汞和锌等也有效,排铅不如EDTA钙,排汞不如BAL。该品可治疗某此免疫性疾病,如类风湿性关节炎、慢性活动性肝炎等。小鼠静脉注射LD50为2289mg/kg。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
D795789MACKLIND-青霉胺10mM in Water198元/1ml;   展开
储存:-20°C
D816687MACKLIND-青霉胺99%63元/1g;   195元/5g;   523元/25g;   1136元/100g;   4006元/500g;   展开
储存:2~8°C
状态:无色或白色固体
折射率:-63 ° (C=1, 1mol/L NaOH)
P0147TCID-Penicillamine>98.0%(T)695元/5G;   2170元/25G;   展开

基本信息

纯度/分析方法>98.0%(T)
分子式/分子量C5H11NO2S = 149.21
外观与形状(20℃)固体
Reaxys-RN1722375
PubChem物质ID87574400
SDBS (AIST Spectral DB)5422
Merck Index (14)7088
MDL编号MFCD00064302

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(Neutralization titration)min. 98.0 %
Specific rotation [a]20/D-61.0 to -65.0 deg(C=1, 1mol/L NaOH sol.)
Solubility in Wateralmost transparency

物性(参考值)

比旋光度 [α]D-63° (C=1,1mol/L NaOH sol.)

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#YV9425000
441428J&KD-(-)-Penicillamine98%551元/5G;   1872元/25G;   展开

基本信息

分子式C5H11NO2S
分子量149.21
熔点210
比旋光度([α]20D)-65° to -61° (C=1, 1 M NaOH)
MDL编码MFCD00064302
Beilstein1722375
Merck14,7088
EINECS 编号200-148-8
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK2
RTECSYV9425000
TSCA
A11446Alfa AesarD-(-)-Penicillamine98%928元/5g;   3739元/25g;   12687元/100g;   展开

应用
It is used mainly as chelating agent in heavy metal poisoning as in lead, mercury and copper poisoning. It is used in Wilson's disease. It ? is used in pharmacy as chelating agent and as immunosuppressant for treating rheumatoid arthritis by reducing the number of T cells, inhibiting the macrophages, by reducing the activity of "Interleukin 1 and rheumatoid factor and in preventing crosslinking of the collagen. It acts as an exogenous NOS modulator.

备注
Stable under normal conditions. Incompatabile to strong oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8?°C.

基本信息

MDL
MFCD00064302

EINECS
200-148-8

分子式
C5H11NO2S

分子量
149.21

熔点
202-204° dec.

灵敏度
Keep Cold.

形态
Powder

溶解性
It is freely soluble in water, slightly soluble in alcohol, insoluble in chloroform, ether, acetone, benzene, and in carbon tetrachloride.

Beilstein
1722375

Merck
14,7088

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P280g-P305+P351+P338
Wear protective gloves.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

RTECS
YV9425000

TSCA

C12974Alfa AesarD(-)-Penicillamine99%1068元/5g;   3557元/25g;   展开

基本信息

Ref#
12974

MDL
64302

分子式
C5 H11 N O2 S

分子量
149.21

形态
White powder

1501006USPPenicillamineUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

线性分子式(CH3)2C(SH)CH(NH2)CO2H
分子量149.21
Beilstein1722375
MDL编号MFCD00064302
PubChem化学物质编号329750678
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp210 ℃ (dec.) (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCC(C)(S)[C@@H](N)C(O)=O
InChI1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1
InChI keyVVNCNSJFMMFHPL-VKHMYHEASA-N

安全信息

象形图GHS08
警示用语:Warning
危险声明H361d
预防措施声明P201 - P308 + P313
危险分类Repr. 2
储存分类代码11 - Combustible Solids
WGKWGK 2
P0310000PenicillamineEuropean Pharmacopoeia (EP) Reference Standard1259.15元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

线性分子式(CH3)2C(SH)CH(NH2)CO2H
分子量149.21
Beilstein1722375
MDL编号MFCD00064302
PubChem化学物质编号329820030
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp210 ℃ (dec.) (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC(C)(S)[C@@H](N)C(O)=O
InChI1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1
InChI keyVVNCNSJFMMFHPL-VKHMYHEASA-N

安全信息

象形图GHS08
警示用语:Warning
危险声明H361d
预防措施声明P201 - P308 + P313
危险分类Repr. 2
储存分类代码11 - Combustible Solids
WGKWGK 2
P4875Sigma-AldrichD-Penicillamine98-101%565.14元/1 G;   1665.8元/5 G;   5780.36元/25 G;   展开

产品说明

一般描述

D-青霉胺含 β-内酰胺化学结构。

应用

在肝豆状核变性病中用作抗风湿药和螯合剂。用作铜螯合剂与半胱氨酸或其他硫化物介质组分形成混合二硫化物。用于灭活蛋白-1dna 结合 ,抑制兔关节软骨细胞异步培养的生长 。

包装

5, 25 g in poly bottle

生化/生理作用

青霉胺是青霉素类抗生素的特征性降解产物。一个铜原子与两个青霉胺分子结合。青霉胺可减少胱氨酸尿症中过量胱氨酸的排泄。这是通过青霉胺和胱氨酸之间的二硫键互换,形成易于排泄的青霉胺-半胱氨酸二硫化物。青霉胺可干扰原胶原分子之间交联的形成,并在新形成时将其裂解。青霉胺降低 IgM 类风湿因子,抑制 T 细胞活性。

其他说明

将容器密闭保存在干燥和通风良好的地方。

基本信息

线性分子式(CH3)2C(SH)CH(NH2)CO2H
分子量149.21
Beilstein1722375
EC 号200-148-8
MDL编号MFCD00064302
PubChem化学物质编号24898564

产品性质

质量水平100
测定98-101%
mp210 ℃ (dec.) (lit.)
溶解性H2O: 100 mg/mL
作用机制cell wall synthesis | interferes
储存温度2-8℃
SMILES stringCC(C)(S)[C@@H](N)C(O)=O
InChI1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1
InChI keyVVNCNSJFMMFHPL-VKHMYHEASA-N
Gene Informationmouse ... Oprk1(18387)

安全信息

象形图GHS08
警示用语:Warning
危险声明H361d
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Repr. 2
储存分类代码11 - Combustible Solids
WGKWGK 2
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
M06142FluorochemH-D-Pen-OH95%440元/5g;   1826元/25g;   4356元/100g;   展开

基本信息

CAS Number52-67-5
MDL NumberMFCD00064302
Melting Point212℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H361fd: Reproductive toxicity
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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