CAS 5184-64-5; mesityl p-tolyl sulfone

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货号

品牌

产品名称

规格

包装、参考价格

详情

E970311

MACKLIN

ESI 05,Epac2抑制剂

98%

1839元/50mg; 2930元/100mg; 5824元/250mg;

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储存：室温

S798975

MESITYL P-TOLYL SULFONE

Aldrich^CPR

1908.94元/50MG;

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产品说明

其他说明

Please note that sigma-aldrich provides this product to early discovery researchers as part of a collection of rare and unique chemicals. sigma-aldrich does not collect analytical data for this product. Buyer assumes responsibility to confirm product identity and/or purity. All sales are final.

NOTWITHSTANDING ANY CONTRARY PROVISION CONTAINED IN SIGMA-ALDRICH'S STANDARD TERMS AND CONDITIONS OF SALE OR AN AGREEMENT BETWEEN SIGMA-ALDRICH AND BUYER, SIGMA-ALDRICH SELLS THIS PRODUCT AS-IS AND MAKES NO REPRESENTATION OR WARRANTY WHATSOEVER WITH RESPECT TO THIS PRODUCT, INCLUDING ANY (A) WARRANTY OF MERCHANTABILITY; (B) WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE; OR (C) WARRANTY AGAINST INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY; WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR OTHERWISE.

基本信息

线性分子式	C₁₆H₁₈O₂S
分子量	274.385
MDL编号	MFCD00091573

SML1907

Sigma-Aldrich

ESI-05

≥98% (HPLC)

1396.09元/5 MG; 4498.97元/25 MG;

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产品说明

应用

ESI-05已被用于研究cAMP 2直接激活的蛋白交换对颅脑损伤的作用。

包装

5, 25 mg in glass bottle

生化/生理作用

ESI-05是一种靶向cAMP调节的鸟嘌呤核苷酸交换因子(GEF)EPAC2(直接由cAMP 2激活的交换因子)激活的选择性抑制剂，其可靶向两个cAMP结合域的交界面上的EPAC2特异性变构位点。在无细胞测定中，ESI-05可以高效地以与cAMP竞争的方式抑制cAMP对EAPC2的激活(IC₅₀ = 430 nM；25 μM cAMP)，但不可抑制EPAC1或PKA。同时，其可抑制表达EPAC2(而非EPAC1)的HEK293转染子中，cPAC类似物007-AM诱导的细胞Rap1的激活。

基本信息

经验(实验)分子式	C₁₆H₁₈O₂S
分子量	274.38
MDL编号	MFCD00091573

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	room temp
SMILES string	CC1=CC=C(S(C2=C(C)C=C(C)C=C2C)(=O)=O)C=C1
InChI	1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3
InChI key	CGPHOZWFSFNOEQ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable