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CAS: 517-23-7
分子式: C6H8O3
分子量: 128.120
沸点: 107-108℃
熔点: <25 °C
中文名称: 
α-乙酰-γ-丁内酮
alpa-乙酰基-gama-丁内酯
3-乙酰基二氢-2(3H)-呋喃酮
α-乙酰基-γ-丁内酯
2-乙酰丁酸内酯
γ-乙酰丁内酯
2-乙酰基丁内酯
α-乙酰-γ-丁内酯
2-乙酰基-γ-丁内酯
英文名称: 
2(3H)-Furanone,3-acetyldihydro-
2-Acetylbutyrolacton
-(-2-Hydroxyethyl)acetoacetic acid -lactone
-Acetyl-hydroxybutyric acid
3-Acetyl-2-(3H)-4,-5-dihydrofuranone
-Acetobutyrolacton
alpha-acetyl-gamma-butyrolactone
3-acetyldihydro-2(3H)-Furanone
.alpha.-Acetyl-.gamma.-butyrolactone
2-Acetylbutyrolactone
3-acetyldihydro-2(3h)-furanon
α-Acetylbutyrolactone
à-Acetyl
3-Acetyl-4,5-dihydro-2(3H)-furanone
alpha-Acetyl-gamma-hydroxybutyric Acid Lactone
展开更多英文名
性质描述: 浅色液体,有类似酯的气味。熔点-12至-13℃,沸点142-143℃(4kPa),107-108℃(667Pa),96℃(0.4kPa),相对密度1.1846(20/4℃),折射率1.4562,闪点110℃。水中溶解度为20%(体积),水在该品中的溶解度为12%(体积)。与铁接触时溶液呈蓝至浅蓝紫色。
生产方法: 1.γ-丁内酯与乙酸乙烯通过Claisen缩合制得。2.乙酰乙酸乙酯(或乙酰乙酸甲酯)与环氧乙烷缩合闭环制得。日本曾以方法1生产,收率比方法(2)稍高,但需要用金属钠,存在安全问题,1965年改用方法2生产。方法2的工艺过程如下:将环氧乙烷加入预先冷却至0℃以下的氢氧化钠,水及乙醇混合液中,滴加乙酰乙酸乙酯,反应温度保持在0℃左右。滴完后继续保温搅拌5-6h,放置过夜,次日在0-3℃保温搅拌8h,再放置过夜,第三天用乙酸中和至ph=8,以氯仿(或苯)分四次抽提,合并各次抽提液,常压回收氯仿(或苯),乙醇后,再减压分馏,85℃/5333Pa以上为低沸物(主要是乙酰乙酸乙酯),100℃/400-667Pa以上为γ-乙酰丁内酯,平均收率近60%粗品含量为90%左右。
用途: 合成维生素B的重要中间体。也是合成3,4-二取代基吡啶和5-(β-羟乙基)-4-甲基噻唑的中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
A800630MACKLINα-乙酰基-γ-丁内酯98%29元/25g;   56元/100g;   140元/500g;   621元/2.5kg;   展开
储存:室温
状态:无色到黄色液体
折射率:n20/D 1.459(lit.)
A742966MACKLINα-乙酰基-γ-丁内酯Standard for GC, ≥99.5%(GC)128元/5g;   展开
储存:室温
状态:液体
A0681TCIα-Acetyl-γ-butyrolactone>99.0%(GC)165元/25G;   625元/500G;   展开

基本信息

纯度/分析方法>99.0%(GC)
分子式/分子量C6H8O3 = 128.13
外观与形状(20℃)液体
Reaxys-RN112676
PubChem物质ID87562238
SDBS (AIST Spectral DB)1650
Merck Index (14)83
MDL编号MFCD00005394

技术规格

AppearanceColorless to Almost colorless clear liquid
Purity(GC)min. 99.0 %

物性(参考值)

沸点108 ℃
闪点135 ℃
比重1.19
折射率1.46
水溶性可溶

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
286824J&K2-Acetylbutyrolactone99%63元/25G;   135元/100G;   260元/250G;   展开

基本信息

分子式C6H8O3
分子量128.13
沸点107-108
闪点113
密度1.19
折光率(n20D)1.4590
MDL编码MFCD00005394
Beilstein112676
Merck14,83
EINECS 编号208-235-2

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK1
RTECSLU3456000
TSCA
B22967Alfa Aesaralpha-Acetyl-gamma-butyrolactone98+%405元/100g;   1260元/500g;   展开

基本信息

MDL
MFCD00005394

EINECS
208-235-2

分子式
C6H8O3

分子量
128.13

沸点
107-108°/5mm

闪点
135°(275°F)

密度
1.190

折射率
1.4590

形态
Liquid

Beilstein
112676

Merck
14,83

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
23-26-37-60
Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

RTECS
LU3456000

TSCA

C10249Alfa Aesar2-Acetylbutyrolactone99+%540元/100ml;   1049元/250ml;   3575元/1L;   展开

基本信息

Ref#
10249

MDL
5394

分子式
C6 H8 O3

分子量
128.13

闪点
140

密度
1.18

形态
Colorless liquid

A13409Sigma-Aldrichα-Acetylbutyrolactone≥99%361.17元/100 G;   398.12元/500 G;   展开

基本信息

经验(实验)分子式C6H8O3
分子量128.13
Beilstein112676
EC 号208-235-2
MDL编号MFCD00005394
PubChem化学物质编号24890534
NACRESNA.22

产品性质

测定≥99%
形式liquid
折射率n20/D 1.459 (lit.)
bp107-108 ℃/5 mmHg (lit.)
密度1.19 g/mL at 25 ℃ (lit.)
SMILES stringCC(=O)C1CCOC1=O
InChI1S/C6H8O3/c1-4(7)5-2-3-9-6(5)8/h5H,2-3H2,1H3
InChI keyOMQHDIHZSDEIFH-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)235.4 °F - closed cup
闪点(C)113 ℃ - closed cup
个人防护装备Eyeshields, Gloves, type ABEK (EN14387) respirator filter
462873Fluorochem3-Acetyldihydrofuran-2(3H)-one95%220元/25g;   638元/100g;   1430元/500g;   展开

基本信息

CAS Number517-23-7
MDL NumberMFCD00005394
Boiling Point108℃
Density1.19

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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